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Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy BJMBR
Machado,F.R.; Pagliari,C.; Caiafa,H.; Tapajós,R.; Duarte,M.I.S..
The objective of the present study was to evaluate the duodenal mucosa of HIV-infected patients during antiretroviral therapy. This was an observational study conducted on HIV-positive patients and a control group. Group 1 comprised 22 HIV-negative individuals while 38 HIV-positive individuals were classified according to the CDC 1993 classification into group 2 (A1 or A2) or group 3 (B2, A3, B3, C2, C3). All subjects were submitted to upper gastrointestinal endoscopy with duodenal biopsies. Qualitative, semi-quantitative and quantitative histological analyses were performed. Results were considered significant when P < 0.05. A higher prevalence of inflammatory infiltrate and eosinophilia was observed in the HIV group, together with a reduction in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intestinal histopathology; Cytokines; Human immunodeficiency virus; Acquired immunodeficiency syndrome; Antiretroviral therapy; CD4+.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100013
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Lung tissue mechanics in the early stages of induced paracoccidioidomycosis in rats BJMBR
Shikanai-Yasuda,M.A.; Pereira,P.M.; Yamashiro-Kanashiro,E.; Duarte,M.I.S.; Assis,C.M.; Geraldes,E.A.; Saldiva,P.H.N..
Pulmonary dysfunction represents the most important cause of death in patients with paracoccidioidomycosis (PBM). In order to investigate the functional changes of the lungs in the early stages of PBM, a model of benign disease was developed by intratracheal challenge of 12-week old isogenic Wistar rats with 1 x 106 yeast forms of Paracoccidioides brasiliensis. Animals were studied 30 and 60 days after infection, when fully developed granulomas were demonstrable in the lungs. Measurements of airway resistance, lung elastance and tissue hysteresis were made during sinusoidal deformations (100 breaths/min, tidal volume = 2 ml) with direct measurement of alveolar pressure using the alveolar capsule technique. Infection caused a significant increase in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental paracoccidioidomycosis; Pulmonary mechanics; Tissue mechanics; Alveolar pressure measurements; Hysteresis.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000006
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