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Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity BJMBR
Aschner,M.; Syversen,T.; Souza,D.O.; Rocha,J.B.T.; Farina,M..
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in astrocytes; b) MeHg specifically inhibits glutamate uptake in astrocytes; c) neuronal dysfunction is secondary to disturbances in astrocytes. The generation of reactive oxygen species (ROS) by MeHg has been observed in various experimental paradigms. For example, MeHg enhances ROS formation both in vivo (rodent cerebellum) and in vitro (isolated rat brain synaptosomes), as well as in neuronal and mixed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylmercury neurotoxicity; Oxidative stress; Glutamate and selenocompounds; Reactive oxygen species; Astrocytes.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300001
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Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions BJMBR
Meinerz,D.F.; de Paula,M.T.; Comparsi,B.; Silva,M.U.; Schmitz,A.E.; Braga,H.C.; Taube,P.S.; Braga,A.L.; Rocha,J.B.T.; Dafre,A.L.; Farina,M.; Franco,J.L.; Posser,T..
We evaluated the potential neuroprotective effect of 1-100 µM of four organoselenium compounds: diphenyl diselenide, 3’3-ditri-fluoromethyldiphenyl diselenide, p-methoxy-diphenyl diselenide, and p-chloro-diphenyl diselenide, against methylmercury-induced mitochondrial dysfunction and oxidative stress in mitochondrial-enriched fractions from adult Swiss mouse brain. Methylmercury (10-100 µM) significantly decreased mitochondrial activity, assessed by MTT reduction assay, in a dose-dependent manner, which occurred in parallel with increased glutathione oxidation, hydroperoxide formation (xylenol orange assay) and lipid peroxidation end-products (thiobarbituric acid reactive substances, TBARS). The co-incubation with diphenyl diselenide (100 µM) completely...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylmercury; Mitochondria; Oxidative stress; Organoselenium compounds; Diphenyl diselenide.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100012
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Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves BJMBR
Farina,M.; Barbosa,N.B.V.; Nogueira,C.W.; Folmer,V.; Zeni,G.; Andrade,L.H.; Braga,A. L.; Rocha,J.B.T..
The interaction of the product of H2O2 and (PhSe)2 with delta-aminolevulinate dehydratase (delta-ALA-D) from mammals and plants was investigated. (PhSe)2 inhibited rat hepatic delta-ALA-D with an IC50 of 10 µM but not the enzyme from cucumber leaves. The reaction of (PhSe)2 with H2O2 for 1 h increased the inhibitory potency of the original compound and the IC50 for animal delta-ALA-D inhibition was decreased from 10 to 2 µM. delta-ALA-D from cucumber leaves was also inhibited by the products of reaction of (PhSe)2 with H2O2 with an IC50 of 4 µM. The major product of reaction of (PhSe)2 with H2O2 was identified as seleninic acid and produced an intermediate with a lambdamax at 265 nm after reaction with t-BuSH. These results suggest that the interaction of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Delta-Aminolevulinate dehydratase; Diphenyl diselenide; Seleninic acid.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600001
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Zinc accumulation in phosphate granules of Ucides cordatus hepatopancreas BJMBR
Corrêa Junior,J.D.; Allodi,S.; Amado-Filho,G.M.; Farina,M..
Amorphous phosphate granules are present in vertebrate and invertebrate organisms. The functions attributed to these structures depend on their mineral contents and organic matrix composition. In the present study we have determined zinc concentrations in the hepatopancreas of the crab Ucides cordatus from regions contaminated with zinc, and the elemental composition of hepatopancreal phosphate granules. Organisms were collected from the contaminated areas of Sepetiba Bay (SB) and Guanabara Bay (GB), and from a non-contaminated area, Ribeira Bay (RB). The first two sites are located near the metropolitan region of Rio de Janeiro city, Brazil. Atomic absorption spectroscopy (AAS) showed a significant difference (P<0.05) for zinc concentration in the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Phosphate granules; Hepatopancreas; Zinc; Energy dispersive X-ray analysis; Atomic absorption spectroscopy; Electron spectroscopic imaging.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200009
Registros recuperados: 4
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