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ハタケシメジ抽出物によるカルボプラチン投与後の白血球数減少抑制作用についての基礎的研究 OAK
清水, 純一郎; 持田, 恭平; 岸本, 海織; 李, 奇子; 池水, 智博; 室谷, 直義; 小嶋, 靖; 山田, 一孝; SHIMIZU, Junichiro; MOCHIDA, Kyohei; KISHIMOTO, Miori; LEE, Ki-Ja; IKEMIZU, Tomohiro; MUROYA, Naoyoshi; KOJIMA, Yasushi; YAMADA, Kazutaka.
ハタケシメジ抽出物の白血球数調節作用を調べる目的でハタケシメジ抽出物を経口投与し,カルボプラチン投与後の骨髄抑制作用の違いを5週間にわたる経時的な血液検査により検討した。その結果,総白血球数および好中球数においてハタケシメジ抽出物投与群がプラセボ投与群に対して有意に高値を示した。このことより,カルボプラチンによる骨髄抑制に対して,ハタケシメジ抽出物が白血球数減少抑制作用を有することが確認された。 In order to elucidate the suppressive effect of Hatakeshimeji (Lyophyllum decastes Sing.) extract on leukocytopenia,the degree of carboplatin-induced myelosuppression was compared between two groups of dogs; each group was daily given Hatakeshimeji extract or only its placebo for 5 weeks,and on day 7, carboplatin,an anticancer agent,was given intravenously to all dogs. Hematological analyses revealed that the nunbers of leukocytes and neutrophils were both significantly higher in the group given Hatakeshimeji extract than in the placebo group. This indicated...
Palavras-chave: カルボプラチン; ; ハタケシメジ抽出物; Carboplatin; Dog; Hatakeshimeji extract.
Ano: 2008 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2929
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腫瘍の犬3症例に対するハタケシメジ抽出物の使用経験 : リンパ球数の変化について OAK
山田, 一孝; 喜澤, 香織; 丹羽, 理恵; 櫻井, 達也; 岸本, 海織; 清水, 純一郎; 室谷, 直義; 池水, 智博; 小嶋, 靖; YAMADA, Kazutaka; KIZAWA, Kaori; NIWA, Rie; SAKURAI, Tatsuya; KISHIMOTO, Miori; SHIMIZU, Junichiro; MUROYA, Naoyoshi; lKEMIZU, Tomohiro; KOJIMA, Yasushi.
腫瘍の犬3症例にハタケシメジ抽出物を投与し経過を観察した。肝腫瘍症例は投与開始から1カ月後に,直腸癌症例は9カ月後に死亡したが,脳腫瘍症例は23カ月経過した現在も生存している。ハタケシメジ抽出物の腫瘍に対する直接的な効果は不明であったが,3症例とも投与後に末梢血液中のリンパ球数が増加した。このことから,ハタケシメジ抽出物には犬の腫瘍症例の末梢リンパ球数を増加させる働きがある可能性が示唆された。 The clinical courses of three canine tumor cases were observed after administration of capsulated Hatakeshimeji extract (Lyophyllum decastes Sing.). The liver tumor case died one month after administration of the ectract,the rectal carcinoma case in nine months. but the brain tumor case is alive for 23 months. However it is unclear what directly effect the administration Hatakeshimeji has on a tumor,the number of lymphocytes increased after the administration of Hatakeshimeji in all thrεe cases. Therefore,it suggests that Hatakeshimeji plays a role in...
Palavras-chave: ; ハタケシメジ抽出物; リンパ球; Dog; Hatakeshimeji (Lyophyllum decastes Sing.); Lymphocyte.
Ano: 2007 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2927
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