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Chiral discrimination of amlodipine from pharmaceutical products using capillary electrophoresis BJPS
Cârcu-Dobrin,Melania; Sabău,Alexandra Georgiana; Hancu,Gabriel; Árpád,Gyéresi; Rusu,Aura; Kelemen,Hajnal; Papp,Lajos Attila; Cârje,Anca.
The present work describes the development of a capillary electrophoresis (CE) method for the chiral discrimination of amlodipine (AML) enantiomers using cyclodextrine (CD) derivatives as chiral selectors. A large number of native and derivatized, neutral and ionized CD derivatives were screened to find the optimal chiral selector; and carboximethyl-β-CD (CM-β-CD) was selected for the enantiomeric discrimination. A factorial analysis study was performed by orthogonal experimental design in which several factors were varied at the same time to optimize the separation method. The optimized method (25 mM phosphate buffer, pH = 9.0, 15 mM CM-β-CD, 15 ºC, + 25 kV, 30 mbar/1 second, detection wavelength 230 nm) was successfully applied for the baseline...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amlodipine; Capillary electrophoresis; Chiral separation; Cyclodextrine; Experimental design.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100530
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Development of a generic method for the determination of proton-pump inhibitors by capillary zoneelectrophoresis BJPS
Papp,Lajos Attila; Gyéresi,Árpád; Hancu,Gabriel; Mircia,Eleonora; Kelemen,Hajnal.
A generic capillary zone electrophoresis method was developed for the analysis of four proton pump inhibitors: omeprazole, pantoprazole, lansoprazole and rabeprazole. During preliminary analysis screening of phosphate buffers at different pH levels was performed, in order to determine the optimum pH domain suitable for the simultaneous determination of all studied compounds. A face centered central composite design was employed for the optimization of separation conditions. The effect of buffer concentration, pH and applied voltage was studied; resolution between peaks and migration time of the last compound were considered as responses. Other factors as system temperature, injection parameters, capillary length, were held constant during the optimization...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Capillary electrophoresis; Proton-pump inhibitors; Experimental design.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100534
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Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography BJPS
Székely-Szentmiklósi,Blanka; Hancu,Gabriel; Székely-Szentmiklósi,István; Kovács,Béla; Kelemen,Hajnal.
Abstract A rapid and sensitive micellar electrokinetic capillary chromatography method with UV photodiode-array detection was developed for the simultaneous determination of atorvastatin and ezetimibe in fixed dose drug combination. Experimental conditions such as buffer concentration and pH, surfactant concentration, system temperature, applied voltage, injection parameters were optimized in order to improve the efficiency of the separation. The best results were obtained when using fused silica capillary (48 cm length X 50 µm ID) and 25 mM borate buffer electrolyte at pH 9.3 containing 25 mM SDS, + 30 kV applied voltage, 20 ºC system temperature. The separation was achieved in approximately 2 minutes, with a resolution of 7.02, the order of migration...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Micellar Electrokinetic Capillary Chromatography; Fixed Dose Drug Combination; Atorvastatin; Ezetimibe..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100626
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