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Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats International Journal of Morphology
Ajayi,S. A; Azu,O. O; Chuturgoon,A; Phulukdaree,A; Komolafe,O. A; Ofusori,D. A.
Testicular toxicity has been implicated in highly active anti-retroviral therapy (HAART) treatment. Hence there is need to identify an effective antioxidant product that can alleviate testicular necrosis due to HAART administration. Forty eight adult male Sprague-Dawley rats were used in this study. The animals were divided into eight (8) groups: A-H (n= 6). Group A animals received normal saline as the control; Group B was given Nevirapine (Nv); Group C was given Kolaviron (Kv); Group D was given vitamin C; Group E was given Nv and Kv; Group F was given Nv and Vitamin C; Group G was given Nv for 56 d and Kv for 28 d serving as a withdrawal group; Group H was given corn oil. Nv, Kv and Vit. C were given at 1.54, 200 and 250 (mg·kg)/bw respectively while...
Tipo: Journal article Palavras-chave: Nevirapine; Kolaviron; Testicular toxicity; Sperm count; Antioxidant enzymes.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100016
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Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia International Journal of Morphology
Komolafe,O. A; Ofusori,D. A; Adewole,O. S; Ayoka,A. O; Bejide,R.
Diabetes mellitus (DM) is a serious metabolic disorder with micro and macro-vascular complications that result in a significant morbidity and mortality. The present study investigated the effects of Momordica charantia (M. charantia) on histological changes of the aorta and pulmonary trunk in streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats...
Tipo: Journal article Palavras-chave: Diabetes; Momordica charantia; Histological; Histochemistry; Aorta; Pulmonary trunk.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200060
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Morphometric Study of Lumbar Vertebrae in Adult South African Subjects International Journal of Morphology
Azu,O. O; Komolafe,O. A; Ofusori,D. A; Ajayi,S. A; Naidu,E. C. S; Abiodun,A. A.
Lumbar vertebral dimensions provide vital clinical information of immense diagnostic benefits to medical experts. The present study provides data for lumbar vertebral dimensions of a cohort of specimens of South African females and males. Measurements were obtained from lumbar vertebrae from the osteological collections in the Discipline of Clinical Anatomy, Nelson Mandela School of Medicine using a digital caliper. The antero-posterior body diameter (APD), interpedicular distance (IPD), midsagittal diameter (MSD) and pedicle length (PL) were measured while ratio of MSD to APD was calculated. Results showed gradual increase from L1 to L5 for mean APD and IPD, and a decrease for mean PL from L1 to L5. Mean MSD was observed to present a "U" curve pattern...
Tipo: Journal article Palavras-chave: Lumbar vertebrae; Morphometry; Adults; South Africa.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400028
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Ultrastructural and Immunohistochemical Effects of Aqueous Leave Extract of Xylopia aethiopica on the Stomach in Streptozotocin-Induced Diabetic Rats International Journal of Morphology
Ofusori,D. A; Komolafe,O. A; Adewole,O. S; Arayombo,B. E; Margolis,D; Naicker,T.
Gastrointestinal pathology in diabetic patients has become a source of concern in recent times. The aim of this study was to investigate the ultrastructural and immunohistochemical effects of aqueous leaf extract of Xylopia aethiopica on the stomach in streptozotocin-induced diabetic rats. This study was conducted using thirty adult Wistar rats. The animals were divided into three groups (n= 10). Group A was the control animals (administered with equivalent volume of citrate buffer), group B was diabetic animals induced by a single intraperitoneal injection of streptozotocin dissolved in citrate buffer (65 mg/kg) and group C was diabetic animals treated with 200 mg/kg body weight of aqueous leave extract of X. aethiopica for twenty five days. At the...
Tipo: Journal article Palavras-chave: Diabetes mellitus; Immunohistochemistry; Ultrastructure; Stomach; Xylopia aethiopic.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100006
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