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Genomic structure, polymorphism and expression of ACCN1 and ACCN3 genes in the horse Inra
Mata, X.; Ducasse, A.; Vaiman, A.; Diribarne, M.; Fraud, A.S.; Guérin, G..
A category of cation gate proteins was shown to be present in sensory neurons and act asreceptors of protons present in tissues such as muscles. The Amiloride-sensitive CationChannel, Neuronal (ACCN) gene family is known to play a role in the transmission of painthrough specialized pH sensitive neurons. Muscles from horses submitted to strenuousexercises produce lactic acid, which may induce variable pain through ACCN differentialproperties. The sequences of the equine cDNAs were determined to be 2.6 kb in length withan open reading frame of 1539 bp for ACCN1 and 2.1 kb in length with an open readingframe of 1602 bp for ACCN3. The ACCN1 gene is 990 kb long and contains 10 exons, andthe ACCN3 gene is 4.2 kb long and contains 11 exons. The equine ACCN1 and...
Tipo: Journal Article Palavras-chave:  ACCN1; ACCN3; Expression; Gene; Horse; Polymorphism.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2011aca8b204&uri=/notices/prodinra1/2011/04/
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Muscular microRNA expressions in healthy and myopathic horses suffering from polysaccharide storage myopathy or recurrent exertional rhabdomyolysis Inra
Barrey, E.; Bonnamy, B; Barrey, E.J.; Mata, X.; Chaffaux, S.; Guérin, G..
Reasons for performing study: MicroRNAs (miRNA) are small endogenous noncoding interfering RNA molecules (18–25 nucleotides) regarded as major regulators in eukaryotic gene expression. They play a role in developmental timing, cellular differentiation, signalling and apoptosis pathways. Because of the central function of miRNAs in the proliferation and differentiation of the myoblasts demonstrated in mouse and man, it is assumed that they could be present in equine muscles and their expression profile may be related to the muscle status.Objective: To identify miRNA candidates in the muscles of control and affected horses suffering from polysaccharide storage myopathy (PSSM) and recurrent exertional rhabdomyolysis (RER).Methods: Muscle biopsies were...
Tipo: Journal Article Palavras-chave: Horse; Transcriptomic; MiRNA profile; Myopathy; RER; PSSM.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2010aa2098f0&uri=/notices/prodinra1/2011/02/
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