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Expression of BAFF and BR3 in patients with systemic lupus erythematosus BJMBR
Duan,J.H.; Jiang,Y.; Mu,H.; Tang,Z.Q..
The objective of this study was to examine the relationship between the expression of B cell activating factor (BAFF) and BAFF receptor in patients with disease activity of systemic lupus erythematosus (SLE). Real-time RT-PCR was used to examine BAFF mRNA expression in peripheral blood monocytes of active and stable SLE patients and healthy controls. The percentage of BAFF receptor 3 (BR3) on B lymphocytes was measured by flow cytometry. Soluble BAFF levels in serum were assayed by ELISA. Microalbumin levels were assayed by an automatic immune analysis machine. BAFF mRNA and soluble BAFF levels were highest in the active SLE group, followed by the stable SLE group, and controls (P<0.01). The percentage of BR3 on B lymphocytes was downregulated in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic lupus erythematosus; Peripheral blood mononuclear cells; B cell-activating factor; BAFF receptor.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300706
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