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Development of a generic method for the determination of proton-pump inhibitors by capillary zoneelectrophoresis BJPS
Papp,Lajos Attila; Gyéresi,Árpád; Hancu,Gabriel; Mircia,Eleonora; Kelemen,Hajnal.
A generic capillary zone electrophoresis method was developed for the analysis of four proton pump inhibitors: omeprazole, pantoprazole, lansoprazole and rabeprazole. During preliminary analysis screening of phosphate buffers at different pH levels was performed, in order to determine the optimum pH domain suitable for the simultaneous determination of all studied compounds. A face centered central composite design was employed for the optimization of separation conditions. The effect of buffer concentration, pH and applied voltage was studied; resolution between peaks and migration time of the last compound were considered as responses. Other factors as system temperature, injection parameters, capillary length, were held constant during the optimization...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Capillary electrophoresis; Proton-pump inhibitors; Experimental design.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100534
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Simultaneous determination of amoxicillin and clavulanic acid in pharmaceutical preparations by capillary zone electrophoresis BJPS
Hancu,Gabriel; Neacşu,Anamaria; Papp,Lajos Attila; Ciurba,Adriana.
ABSTRACT Clavulanic acid enhances the antibacterial spectrum of amoxicillin by rendering most β-lactamase producing isolates susceptible to the drug. A fast, simple and efficient capillary electrophoresis method was developed for the simultaneous determination of amoxicillin and clavulanic acid from complex mixtures. Using a 25 mM sodium tetraborate as background electrolyte at a pH of 9.30, + 25 kV applied voltage, 25 °C system temperature, UV determination at 230 nm; we succeeded in simultaneous separation of amoxicillin and clavulanic acid in approximately 2 minutes. The analytical performance of the method was evaluated in terms of reproducibility, precision, accuracy, and linearity. The optimized analytical method was applied for the determination of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amoxicillin/determination; Clavulanic acid/determination; Capillary electrophoresis/quantitative analysis; Antibacterials/quantitative analysis.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200281
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