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Avaliação da imobilidade tônica em codornas de corte via análise de sobrevivência Arq. Bras. Med. Vet. Zootec.
Caetano,G.C.; Silva,F.F.; Silva,L.P.; Paula,C.; Silva,H.T.; Paiva,J.T.; Soares,A.C.C.; Mariano,W.H..
ABSTRACT Tonic immobility (TI) is a way to measure fear, as characterized by the reduced capacity to respond to external stimuli. The time spent in TI indicates the level of fear. Since TI is measured as the time until event occurrence, survival analysis stands out as a suitable statistical method to treat these data. We aimed to investigate the influence of possible factors (lines, sex and age) on fear behavior in meat quail (Coturnix coturnix) measured through TI by using survival analysis (non parametric Kaplan-Meyer method via logrank test). The dataset was composed by TI information provided by 50 animals from each line (UFV1 and UFV2) in each age (14 and 28 days of age), totalizing 200 records. Despite the slight difference between the two evaluated...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Coturnix coturnix; Curvas de sobrevivência; Kaplan-Meyer; Teste log-rank.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000301009
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Rescuing axons from degeneration does not affect retinal ganglion cell death BJMBR
de Lima,S.; Mietto,B.S.; Paula,C.; Muniz,T.; Martinez,A.M.B.; Gardino,P.F..
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies show features characteristic of attempts to initiate the regenerative process of elongating their axons. The main molecular event that leads to WD is an increase in the intracellular calcium concentration, which activates calpains, calcium-dependent proteases that degrade cytoskeleton proteins. The aim of our study was to investigate whether preventing axonal degeneration would impact the survival of retinal ganglion cells (RGCs) after crushing the optic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Optic nerve crush; Calpain inhibitor; Axon preservation; Axon degeneration; Retinal ganglion cells; Cell survival.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400705
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