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Experimental chronic entrapment of the sciatic nerve in adult hamsters: an ultrastructural and morphometric study BJMBR
Prinz,R.A.D.; Nakamura-Pereira,M.; De-Ary-Pires,B.; Fernandes,D.S.; Fabião-Gomes,B.D.S.V.; Bunn,P.S.; Martinez,A.M.B.; Pires-Neto,M.A.; Ary-Pires,R..
Entrapment neuropathy is a group of clinical disorders involving compression of a peripheral nerve and interference with nerve function mostly through traction injury. We have investigated the chronic compression of peripheral nerves as an experimental procedure for detecting changes in ultrastructural nerve morphology. Adult hamsters (Mesocricetus auratus, N = 30) were anesthetized with a 25% pentobarbital solution and received a cuff around the right sciatic nerve. Left sciatic nerves were not operated (control group). Animals survived for varying times (up to 15 weeks), after which they were sacrificed and both sciatic nerves were immediately fixed with a paraformaldehyde solution. Experimental nerves were divided into segments based upon their distance...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Nerve entrapment; Ultrastructure; Morphometry; Hamster; Renaut body.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900015
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Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons BJMBR
Pires-Neto,M.A.; Braga-de-Souza,S.; Lent,R..
Axon growth and guidance represent complex biological processes in which probably intervene diverse sets of molecular cues that allow for the appropriate wiring of the central nervous system (CNS). The extracellular matrix (ECM) represents a major contributor of molecular signals either diffusible or membrane-bound that may regulate different stages of neural development. Some of the brain ECM molecules form tridimensional structures (tunnels and boundaries) that appear during time- and space-regulated events, possibly playing relevant roles in the control of axon elongation and pathfinding. This short review focuses mainly on the recognized roles played by proteoglycans, laminin, fibronectin and tenascin in axonal development during ontogenesis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Axon guidance; Development; Anterior commissure; Corpus callosum; Brain.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500017
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