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Registros recuperados: 17
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A gene-transcription factor network associated with residual feed intake based on SNVs/InDels identified in Gir, Girolando and Holstein cattle breeds. Repositório Alice
VERARDO, L. L.; STAFUZZA, N. B.; MUNARI, D. P.; ZERLOTINI NETO, A.; CHUD, T. C. S.; GARRICK, D. J.; COLE, J. B.; PANETTO, J. C. do C.; MACHADO, M. A.; MARTINS, M. F.; SILVA, M. V. G. B..
The aim of this study was to analyze whole-genome re-sequencing data focusing on SNVs and InDels identified in Gir, Girolando and Holstein cattle breeds related to RFI. Thus, genes showing SNVs/InDels in TF binding sites (5' UTR variants) were used to search for TF related to feed intake and to generate a gene-TF network for RFI across two purebred and one admixed dairy cattle breeds. Moreover, we were able to perform a comparative analysis accessing similarities and dissimilarities at the genomic level across these breeds.
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Sequência de dados; Single Nucleotide Variations (SNVs); Insertions/deletions (InDels); Whole-genome; Whole-genome re-sequencing data; Gado de Corte; Bos Indicus; Variação Genética; Cattle breeds.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1105518
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Assessment of runs of homozygosity islands and estimates of genomic inbreeding in Gyr (Bos indicus) dairy cattle. Repositório Alice
PERIPOLLI, E.; STAFUZZA, N. B.; MUNARI, D. P.; LIMA, A. L. F.; IRGANG, R.; MACHADO, M. A.; PANETTO, J. C. do C.; VENTURA, R. V.; BALDI, F.; SILVA, M. V. G. B..
Abstract BACKGROUND: Runs of homozygosity (ROH) are continuous homozygous segments of the DNA sequence. They have been applied to quantify individual autozygosity and used as a potential inbreeding measure in livestock species. The aim of the present study was (i) to investigate genome-wide autozygosity to identify and characterize ROH patterns in Gyr dairy cattle genome; (ii) identify ROH islands for gene content and enrichment in segments shared by more than 50% of the samples, and (iii) compare estimates of molecular inbreeding calculated from ROH (FROH), genomic relationship matrix approach (FGRM) and based on the observed versus expected number of homozygous genotypes (FHOM), and from pedigree-based coefficient (FPED). RESULTS: ROH were identified in...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Dairy traits; Inbreeding coefficients; ROH islands; Bos Indicus.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1100275
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Association of apolipoprotein B and adiponectin receptor 1 genes with carcass, bone integrity and performance traits in a paternal broiler Line. Repositório Alice
CRUZ, V. A. R. da; SCHENKEL, F. S.; SAVEGNAGO, R. P.; GRUPIONI, N. V.; STAFUZZA, N. B.; SARGOZAEL, M.; IBELLI, A. M. G.; PEIXOTO, J. de O.; LEDUR, M. C.; MUNARI, D. P..
Apolipoprotein B (APOB) and Adiponectin Receptor 1 (ADIPOR1) are related to the regulation of feed intake, fat metabolism and protein deposition and are candidate genes for genomic studies in birds. In this study, associations of two single nucleotide polymorphisms (SNPs) g.102A>T (APOB) and g.729C>T (ADIPOR1) with carcass, bone integrity and performance traits in broilers were investigated. Genotyping was performed on a paternal line of 1,454 broilers. The SNP detection was carried out by PCR-RFLP technique using the restriction enzymes HhaI for the SNP g.729C>T and MslI for the SNP g.102A>T. The association analyses of the two SNPs with 85 traits were performed using the restricted maximum likelihood (REML) and Generalized Quasi-Likelihood...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Frango de corte; Carcaça; Genética animal.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1025860
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Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. Repositório Alice
GRUPIONI, N. V.; STAFUZZA, N. B.; CARVAJAL, A. B.; IBELLI, A. M. G.; PEIXOTO, J. de O.; LEDUR, M. C.; MUNARI, D. P..
Abstract: Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Analyses of genetic association between single-nucleotide polymorphisms (SNPs) and traits were carried out using the maximum likelihood procedures for mixed models. Genetic...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Melhoramento genético animal; Frango de corte; Animal breeding; Broiler chickens.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069536
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Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits. Repositório Alice
PERIPOLLI, E.; METZGER, J.; LEMOS, M. V. A. de; STAFUZZA, N. B.; KLUSKA, S.; OLIVIERI, B. F.; FEITOSA, F. L. B.; BERTON, M. P.; LOPES, F. B.; MUNARI, D. P.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; DENISE, S.; PEREIRA, A. S. C.; BALDI, F..
Abstract Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages. It attempts also to compare estimates of inbreeding calculated from ROH (FROH), genomic relationship matrix (FGRM), and pedigree-based coefficient (FPED). Results The average number of ROH per animal was 55.15 ± 13.01 with an average size of 3.24 Mb. The Nellore genome is composed mostly by a high number of shorter segments accounting for 78% of all ROH, although the proportion of the genome covered by them was relatively small. The genome autozygosity proportion indicates moderate to high inbreeding levels...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Padroes ROH; Endogamia; Gado Nelore; Genoma; Genética Animal; Homozygosity.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1101339
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Avaliação de abordagens estatísticas para análise da expressão gênica diferencial em dados reais de RNA-seq Repositório Alice
SBARDELLA, A. P; FONSECA, I.; WELLER, M. A. DEL C. A.; STAFUZZA, N. B.; OLIVEIRA, J. R,; WATANABE, R. N.; COSTA, R, M. da; CARVAJAL, A. B.; SILVA, M. V. G. B.; MARTINS, M. F.; MUNARI, D. P..
2017
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Expressão diferencial; Bovinos de leite; Sequenciamento.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1072447
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Candidate genes for male and female reproductive traits in Canchim beef cattle. Repositório Alice
BUZANSKAS, M. E.; GROSSI, D. do A.; VENTURA, R. V.; SCHENKEL, F. S.; CHUD, T. C. S.; STAFUZZA, N. B.; ROLA, L. D.; MEIRELLES, S. L. C.; MOKRY, F. B.; MUDADU, M. de A.; HIGA, R. H.; SILVA, M. V. G. B.; ALENCAR, M. M. de; REGITANO, L. C. de A.; MUNARI, D. P..
Background: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals. Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Polimorfismo de nucleotídeo único; Gado de corte; Gado Canchim; Beef cattle; Genome-wide association study; Single nucleotide polymorphism; Quantitative trait loci.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1074373
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Detection of potential genetic variants affecting gene function in Guzerat cattle. Repositório Alice
ZERLOTINI NETO, A.; STAFUZZA, N. B.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; SILVA, M. V. G. B..
Guzerat is a dual-purpose breed recognized for important traits to its adaptation to adverse tropical environments such as resistance to parasites, heat tolerance and ability to intake forage with low nutritional value. Once genetic variation responsible for this traits has so far not been well characterized, the aim of this study was to identity single nucleotide variants (SNVs) and insertion/deletions (Indels) in Guzerat cattle breed from whole genome re-sequencing in order to characterize loss-of-function variants which could be associated with complex traits in this cattle breed.
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Bioinformática; Single nucleotide variants; Bioinformatics; Cattle.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1067540
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Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers. Repositório Alice
RAGOGNETTI, B. do N. N; STAFUZZA, N. B.; SILVA, T. B. R. da; CHUD, T. C. S.; GRUPIONI, V. A. R.; CRUZ, V. A. R.; DANTAS, J. de O.; NONES, K.; LEDUR, M. C.; MUNARI, D. P..
Abstract: Selection among broilers for performance traits is resulting in locomotion problems and bone disorders, once skeletal structure is not strong enough to support body weight in broilers with high growth rates. In this study, genetic parameters were estimated for body weight at 42 days of age (BW42), and tibia traits (length, width, and weight) in a population of broiler chickens. Quantitative trait loci (QTL) were identified for tibia traits to expand our knowledge of the genetic architecture of the broiler population. Genetic correlations ranged from 0.56 +/- 0.18 (between tibia length and BW42) to 0.89 +/- 0.06 (between tibia width and weight), suggesting that these traits are either controlled by pleiotropic genes or by genes that are in linkage...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Mapeamento genético; Genética animal; Frango de corte; Parâmetro genético; Animal genetics; Molecular genetics; Broiler chicken.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1045310
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Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle. Repositório Alice
STAFUZZA, N. B.; SILVA, R. M. de O.; PERIPOLLI, E.; BEZERRA, L. A. F.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; MUNARI, D. P.; LOURENCO, D. A. L.; BALDI, F..
Abstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1:...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Gado Nelore; Mutação; Bos Indicus.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1101347
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Ilhas de homozigose para identificação de genes relacionados com características de importância econômica na pecuária leiteira em bovinos da raça Gir (Bos primigenius indicus) Repositório Alice
PERIPOLLI, E.; CHIAIA, H. L. J.; BERTON, M. P.; KLUSKA, S.; STAFUZZA, N. B.; MUNARI, D. P.; PANETTO, J. C. do C.; MACHADO, M. A.; VENTURA, R. V.; BALDI, F.; SILVA, M. V. G. B..
2017
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Autozigosidade; Características Leiteiras.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1072319
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Non-hierarchical cluster analysis for body weight, age at first egg, egg production and egg weight in a laying hen strain. Repositório Alice
FREITAS, L. A. de; GRUPIONI, N. V.; SAVEGNAGO, R. P.; STAFUZZA, N. B.; FIGUEIREDO, E. A. P. de; SCHMIDT, G. S.; LEDUR, M. C.; MUNARI, D. P..
2016
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Genetic association; Laying hens; Multivariate analysis.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1053160
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Selection signatures in Canchim beef cattle Repositório Alice
URBINATI, I.; STAFUZZA, N. B.; OLIVEIRA, M. T.; CHUD, T. C. S.; HIGA, R. H.; REGITANO, L. C. de A.; ALENCAR, M. M. de; BUZANSKAS, M. E.; MUNARI, D. P..
Background: Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism (SNP) panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures (SS). The SS are detectable by different methods, such as the extended haplotype homozygosity (EHH); and the integrated haplotype score (iHS), which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle (composite breed), genotyped with high-density SNP panel. Results: A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The iHS statistic for each...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Genômica; Polimorfismo de nucleotídeo único; Extended haplotype homozygosity; Gado de corte; Composite breeds; Genomics; Single nucleotide polymorphism; Beef cattle; Quantitative trait loci.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1061492
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Selection signatures in Canchim beef cattle. Repositório Alice
URBINATI, I.; STAFUZZA, N. B.; OLIVEIRA, M. T.; CHUD, T. C. S.; HIGA, R. H.; REGITANO, L. C. de A.; ALENCAR, M. M. de; BUZANSKAS, M. E.; MUNARI, D. P..
bitstream/item/144539/1/Urbinati-JASB-2016.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: SNP; Cruzamento; Cruzamento Animal; Genótipo; Genomics.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1047351
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Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds. Repositório Alice
STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; COLE, J. B.; SILVA, M. V. G. B..
Whole-genome re-sequencing, alignment and annotation analyses were undertaken for 12 sires representing four important cattle breeds in Brazil: Guzerat (multi-purpose), Gyr, Girolando and Holstein (dairy production). A total of approximately 4.3 billion reads from an Illumina HiSeq 2000 sequencer generated for each animal 10.7 to 16.4-fold genome coverage. A total of 27,441,279 single nucleotide variations (SNVs) and 3,828,041 insertions/ deletions (InDels) were detected in the samples, of which 2,557,670 SNVs and 883,219 InDels were novel. The submission of these genetic variants to the dbSNP database significantly increased the number of known variants, particularly for the indicine genome. The concordance rate between genotypes obtained using the Bovine...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Potential genomic markers; Important traits; Single nucleotide variations; Genetic variants.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1072234
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Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds. Repositório Alice
STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; COLE, J. B.; SILVA, M. V. G. B. da.
bitstream/item/180929/1/journal.pone.0173954.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Molecular mechanisms; Raças bovinas; Genomic markers; Sires.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069769
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Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds. Repositório Alice
STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; COLE, J. B.; SILVA, M. V. G. B..
Whole-genome re-sequencing, alignment and annotation analyses were undertaken for 12 sires representing four important cattle breeds in Brazil: Guzerat (multi-purpose), Gyr, Girolando and Holstein (dairy production). A total of approximately 4.3 billion reads from an Illumina HiSeq 2000 sequencer generated for each animal 10.7 to 16.4-fold genome coverage. A total of 27,441,279 single nucleotide variations (SNVs) and 3,828,041 insertions/deletions (InDels) were detected in the samples, of which 2,557,670 SNVs and 883,219 InDels were novel. The submission of these genetic variants to the dbSNP database significantly increased the number of known variants, particularly for the indicine genome. The concordance rate between genotypes obtained using the Bovine...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Polimorfismo de nucleotídeo único; Single nucleotide variations; Important traits; Genetic variants; Gado; Variação genética; Genome; Single nucleotide polymorphism; Cattle breeds.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1086824
Registros recuperados: 17
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