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Characterization analysis and polymorphism detection of the porcine Myd88 gene Genet. Mol. Biol.
Li,Xinyun; Liu,Huazhen; Shulin,Yang; Tang,Zhonglin; Ma,Yuehui; Chu,Mingxing; Li,Kui.
The myeloid differentiation primary response protein 88 (Myd88) is an essential adaptor protein, which mediates in all Toll-like receptor (TLR) members signal transduction, except for TLR3. In this study, the 4464 bp genomic sequence of porcine Myd88 was first isolated, whereupon tissue distribution, chromosome mapping and single nucleotide polymorphism (SNP) were analyzed. Our results revealed that porcine Myd88 gene, which was located at chromosome 13 linked with marker S0288 (distance = 40 cR; LOD = 8.66), was widely expressed in all the examined tissues. There were 16 potential SNPs in the isolated genome fragment. SNP 797T/C in the first intron was studied, with no significant association being found between the genotype and immune traits in pigs (p...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myd88; TLR; Polymorphism; Pig; Chromosome mapping.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200015
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