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Acetylcholinesterase activity in the pons and medulla oblongata of rats after chronic electroconvulsive shock BJMBR
Camarini,R.; Benedito,M.A.C..
An imbalance between cholinergic and noradrenergic neurotransmission has been proposed for the etiology of affective disorders. According to this hypothesis, depression would be the result of enhanced cholinergic and reduced noradrenergic neurotransmission. Repeated electroconvulsive shock (ECS) is an effective treatment for depression; moreover, in laboratory animals it induces changes in brain noradrenergic neurotransmission similar to those obtained by chronic treatment with antidepressant drugs (down-regulation of beta-adrenergic receptors). The aim of the present study was to determine whether repeated ECS in rats changes acetylcholinesterase (Achase) activity. Achase controls the level of acetylcholine (Ach) in the synaptic cleft and its levels seem...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Medulla oblongata; Pons; Chronic electroconvulsive shock.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000012
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Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats Anais da ABC (AABC)
TEODORAK,BRENA P.; FERREIRA,GABRIELA K.; SCAINI,GISELLI; WESSLER,LETÍCIA B.; HEYLMANN,ALEXANDRA S.; DEROZA,PEDRO; VALVASSORI,SAMIRA S.; ZUGNO,ALEXANDRA I.; QUEVEDO,JOÃO; STRECK,EMILIO L..
Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by increasing dopamine levels in the synaptic cleft. Considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats. Young male Wistar rats received a single injection of fenproporex (6.25, 12.5 or 25mg/kg i.p.) or vehicle (2% Tween 80). Two hours after the injection, the rats were killed by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Amphetamine; Dopamine; Fenproporex.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301389
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Anticholinesterase effect of eserine (physostigmine) in fish and crustacean species BABT
Monserrat,José M.; Bianchini,Adalto.
The kinetic characteristic (Km) of cholinesterase from the crab Chasmagnathus granulata, the shrimp Farfantepenaeus paulensis and the fish Odontesthes bonaeriensis were compared and correlated with the anticholinesterasic effect of eserine (physostigmine). For the crustaceans, the estimated Km values were about 5-8 times higher than that estimated for the fish (0.04 mM). In the crab and the shrimp, the concentration of eserine which inhibited 50% of cholinesterase activity (IC50) was estimated as 5.33x10-4 and 4.33x10-4 mM, respectively. In both cases, it was significantly higher (P < 0.05) than that estimated for the fish larvae (7.43x10-5 mM). A high Km could reflect a lower affinity of the cholinesterase for its natural substrate, acetylcholine, or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Eserine; Physostigmine; Acetylcholinesterase; Fish; Silverside fish; Crustacean.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000100009
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Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders Biol. Res.
Ahmad,Sajjad; Ullah,Farhat; Ayaz,Muhammad; Sadiq,Abdul; Imran,Muhammad.
BACKGROUND: Rumex species are traditionally used for the treatment of neurological disorders including headache, migraine, depression, paralysis etc. Several species have been scientifically validated for antioxidant and anticholinestrase potentials. This study aims to investigate Rumex hastatus D. Don crude methanolic extract, subsequent fractions, saponins and flavonoids for acetylcholinestrase, butyrylcholinestrase inhibition and diverse antioxidant activities to validate its folkloric uses in neurological disorders. Rumexhastatus crude methanolic extract (Rh. Cr), subsequent fractions; n-hexane (Rh. Hex), chloroform (Rh. Chf), ethyl acetate (Rh. EtAc), aqueous fraction (Rh. Aq), crude saponins (Rh. Sp) and flavonoids (Rh. Fl) were investigated against...
Tipo: Journal article Palavras-chave: Ethnomedicinal; Acetylcholinesterase; Butyrycholinesterase; DPPH; ABTS.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100020
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Biochemical and genetic alterations in the freshwater neotropical fish Prochilodus lineatus after acute exposure to Microcystis aeruginosa Neotropical Ichthyology
Garcia,Cylene Zambrozi; Martinez,Claudia B. R..
Microcystins are secondary metabolites produced by different species of cyanobacteria, such as Microcystis aeruginosa (MA). In this study, the biochemical and genetic effects of lyophilized MA were evaluated in the neotropical fish Prochilodus lineatus exposed to 1 or 2 mg L-1 lyophilized MA (treated group) or only water (control group) in static toxicity tests for 24 and 96 h. The gills and liver were used in the analysis of biotransformation enzymes and antioxidant defenses, blood and gill cells in genetic analysis and in brain and muscle it was determined the activity of acetylcholinesterase (AChE). The results showed the biotransformation pathway activation due to the increase in hepatic CYP1A and in branchial and hepatic glutathione S-transferase...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Antioxidants; Biotransformation; Cyanotoxin; DNA damage.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252012000300015
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Biomarkers of oxidative stress and acetylcholinesterase activity in the blood of grass snake (Natrix natrix L.) during prehibernation and posthibernation periods BABT
Gavric,Jelena; Prokic,Marko; Despotovic,Svetlana; Gavrilovic,Branka; Radovanovic,Tijana; Borkovic-Mitic,Slavica; Pavlovic,Sladan; Saičic,Zorica.
This work examined the enzymatic (superoxide dismutase-CuZn SOD, catalase-CAT, glutathione peroxidase-GSHPx, glutathione reductase-GR, and the biotransformation phase II enzyme glutathione-S-transferase-GST) and nonenzymatic (total glutathione-GSH and lipid peroxides-TBARS concentrations) biomarkers of oxidative stress and acetylcholinesterase (AChE) activity in the blood of the grass snake (Natrix natrix L.) during prehibernation and posthibernation. The animals were collected in October (prehibernation) and April (posthibernation) at the nature reserve Obedska Bara (OB) and industrial region Pancevacki Rit (PR) in Serbia. In posthibernation, decreased CAT activity and TBARS concentration in specimens from PR, and decreased GR and AChE activities, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Grass snake; Oxidative stress; Hibernation; Acetylcholinesterase; Antioxidant enzymes.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300443
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Characterization of acetylcholinesterase from the brain of the Amazonian tambaqui (Colossoma macropomum) and in vitro effect of organophosphorus and carbamate pesticides. Repositório Alice
ASSIS, C. R. D.; CASTRO, P. F. de; AMARAL, I. P. G.; CARVALHO, E. V. M. M.; CARVALHO JUNIOR, L. B.; BEZERRA, R. S..
2010
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Organophosphorus pesticide; Carbamate pesticide; Acetylcholinesterase; Biomarkers.
Ano: 2010 URL: http://www.alice.cnptia.embrapa.br/handle/doc/871124
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Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions BJMBR
Camarini,R.; Benedito,M.A.C..
Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic neurotransmission. In order to identify possible changes in cholinergic neurotransmission we measured total, membrane-bound and soluble acetylcholinesterase (Achase) activity in several rat brain regions after chronic imipramine treatment. Changes in Achase activity would indicate alterations in acetylcholine (Ach) availability to bind to its receptors in the synaptic cleft. Male rats were treated with imipramine (20 mg/kg, ip) for 21 days, once a day. Twenty-four hours after the last dose the rats were sacrificed and homogenates from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Imipramine; Brain; Antidepressants.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800007
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Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae) Biol. Res.
Dzoyem,Jean P.; Tsamo,Armelle T.; Melong,Raduis; Mkounga,Pierre; Nkengfack,Augustin E.; McGaw,Lyndy J.; Eloff,Jacobus N..
BACKGROUND: Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric oxide (NO) and acetylcholinesterase (AChE) inhibitory activity and the cytotoxicity of three limonoids: trichilia lactone D5 (1), rohituka 3 (2) and dregeanin DM4 (3), isolated from Trichilia welwitschii C.DC RESULTS: Results indicated that the three limonoids had low cytotoxicity towards Vero cells with LC50 values ranging from 89.17 to 75.82 (&#956;g/L. Compounds (2) and (3) had lower cytotoxicity compared to puromycin and doxorubicin...
Tipo: Journal article Palavras-chave: Trichilia welwitschii; Cytotoxicity; Acetylcholinesterase; Nitric oxide; Limonoids.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100057
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Dalbergia ecastaphyllum leaf extracts: in vitro inhibitory potential against enzymes related to metabolic syndrome, inflammation and neurodegenerative diseases Biological Sciences
Morais, Daniel Vieira de; Moreira, Manuela Maria; Silva, Fabiane de Lima; Costa, Maria Angélica Pereira de Carvalho; Delerue-Mato, Cristina; Carvalho, Carlos Alfredo Lopes de; Estevinho, Maria Leticia Miranda.
For the first time, the anti-hemolytic activity and the enzyme inhibitory activities of Dalbergia ecastaphyllum leaves extracts were tested against α-amylase, α-glucosidase, lipase, acetylcholinesterase, butyrylcholinesterase, tyrosinase and hyaluronidase. The phenolic profile of the obtained extracts was also investigated by high-performance liquid chromatography with photodiode array detection (HPLC-PAD). The extracts showed inhibitory activity against all enzymes evaluated, with the highest inhibitory activity reported for the enzyme hyaluronidase (28.28 ± 2.43 to 72.19 ± 1.40 μg mL-1). The obtained extracts also demonstrate anti-hemolytic activity (52.22 ± 1.62 to 71.17 ± 1.82%). Among the phenolic compounds identified, protocatechuic, vanillic and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Α-glucosidase; Hyaluronidase; Preclinical research..
Ano: 2019 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46622
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Ecotoxicity assessment of functionalized activated charcoal on the activity of the enzyme acetylcholinesterase and its effect in the presence of pesticides. Repositório Alice
VIANNA, M.; NOVOTNY, E. H.; SILVA, T. S.; RIBEIRO, B. R.; DITTZ, L. A..
The study of soil organic matter of the "Terras Pretas de Índios" showed an efficient compost model for improving the physical chemistry properties of the soil. The charred materials have the condensed aromatic structures but it does not provide carboxylic groups, that are important for its reactivity and its contribution to soil CEC. The objective of this study is to evaluate the ecotoxicity of functionalized charcoal compounds (humic acids like material - HALM) through its sub-lethal kinetic behaviour of the enzyme AChE even in the presence of pesticides. Activated charcoal was chemically oxidized using sodium hypochlorite. Brains of rats were used for ecotoxicity assay. The IC (half maximal inhibitory concentration) for AChE was 65 mg L-1 of HALM. The...
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Biochar; Acetilcolinesterase; Ecotoxicidade; Pesticida; Toxicidade; Pesticides; Acetylcholinesterase; Ecotoxicology.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1001331
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Effect of Dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) Brain. Repositório Alice
ASSIS, C. R. D.; AMARAL, I. P. G.; CASTRO, P. F.; CARVALHO JÚNIOR, L. B.; BEZERRA, R. S..
Dichlorvos is an acutely toxic organophosphorous pesticide that is known as a classical acetylcholinesterase (AChE; EC 3.1.1.7) inhibitor. Here, the brain AChE from the important Amazonian fish tambaqui (Colossoma macropomum) was assayed in the presence of this insecticide and also of deltamethrin, a classical sodium and potassium channel inhibitor (negative control). Four tissue homogenates were analyzed in triplicate for AChE activity using acetylthiocholine as the substrate and 5,5'-dithiobis(2-nitrobenzoic) acid (DTNB) as the color-developing agent. Each tissue homogenate represented pooled brains from five fish. The inhibitory effect of dichlorvos on AChE activities was determined at concentrations from 0.001 to 10 ppm and compared to controls. This...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Organophosphorous pesticide; Dichlorvos; Biomarker; Acetylcholinesterase; Tambaqui; Colossoma macropomum.
Ano: 2007 URL: http://www.alice.cnptia.embrapa.br/handle/doc/69727
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Effect of methyl parathion on the muscle and brain acetylcholinesterase activity of matrinxã (Brycon cephalus) Ciência Rural
Almeida,Luciana Cristina de; Aguiar,Lúcia Helena; Moraes,Gilberto.
Farming of the freshwater fish is emerging in Brazil and many species from the wild are promising. The teleost matrinxã (Brycon cephalus) holds several characteristics such as fast growth rate, high commercial value and adaptability to artificial raring conditions, which make it a promising species for commerce. The use of pesticides in aquatic environment is frequent in Brazil, and methyl parathion is very common in aquaculture. We have determined the enzymatic activity of acetyl cholinesterase in white muscle and brain of matrinxã exposed to 2ppm of environmental methyl parathion for 24 hours. There was 64% and 69% of acetyl cholinesterase inhibition in muscle and brain respectively. These activities were not recovered after 8 days from exposure to this...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Methyl parathion; Matrinxã; Toxicity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782005000600029
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Effect of oral exposure to the acaricide pirimicarb, a new varroacide candidate, on apis mellifera feeding rate ArchiMer
Riva, Clemence; Sokolowski, Michel B. C.; Normand, Julien; Santos, Jana Sopkova-de Oliveira; Halm-lemeille, Marie-pierre.
BACKGROUND The ectoparasitic honey bee mite Varroa destructor is one of the main causes related to the gradual decline of honey bees Apis mellifera. Nowadays, beekeepers utilize a wide range of different synthetic acaricides, organic acids and essential oils to keep mite populations under control. A previous work had shown that pirimicarb could be a new varroacide candidate. The aim of this study was to observe the chronic effects on worker honey bees feeding activity after an oral exposure to 1.05 mM of pirimicarb. Long-term effect of a 24 hours exposition to pirimicarb were also tested. RESULTS After three successive trials were performed, no mortality could be detected at the tested concentration, oral exposure to pirimicarb had significant effect on...
Tipo: Text Palavras-chave: Apis mellifera; Varroa destructor management; Acaricide; Pirimicarb; Acetylcholinesterase.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00423/53466/54362.pdf
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Effects of Androctonus crassicauda (Olivier, 1807) (scorpiones: buthidae) venom on rats: correlation among acetylcholinesterase activities and electrolytes levels J. Venom. Anim. Toxins incl. Trop. Dis.
Ozkan,O.; Adiguzel,S.; Kar,S.; Kurt,M.; Yakistiran,S.; Cesaretli,Y.; Orman,M.; Karaer,Z..
Scorpions can be considered living fossils because they have changed so little during the last 400 million years. They are venomous arthropods of the Arachnida class and regarded as relatives of spiders, ticks and mites. The aim of the present study was to evaluate the toxicity of Androctonus crassicauda (Olivier, 1807) venom and its effects on the acetylcholinesterase (AchE) activity and on electrolytes levels in rats. Animals were divided into seven groups of five rats each. Test groups received 250µg/kg of venom solution while control group was treated with 200µl of physiological saline solution (PSS). Blood samples were collected from the animals on the 1st, 2nd 4th, 8th, 12th, and 24th hours after subcutaneous injection of venom. Animals were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Androctonus crassicauda; Venom; Acetylcholinesterase; Electrolytes.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100005
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Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets Anais da ABC (AABC)
MÜLLER,LUCIELI K.F.; SILVA,ALEKSANDRO S. DA; BOTTARI,NATHIELI B.; SANTURIO,JANIO M.; MORSCH,VERA M.; PIVA,MANOELA M.; MENDES,RICARDO E.; GLORIA,EDUARDO M.; PAIANO,DIOVANI.
Abstract: The aim of this study was to evaluate the effect of spray-dried porcine plasma (SDPP) supplementation on cholinesterase enzymes and its relationship with animal behavior of weaning piglets exposed to mycotoxin contaminated diets. To achieve these objectives, two experimental design approaches were used. Male piglets (7.15±0.61kg) were allocated in four groups: CTL group received a regular diet; SDPP group received a regular diet and 6% SDPP; MYC group received a diet containing desired contamination of 210 µg/kg aflatoxins and 6.690 µg/kg fumonisins; group MYC+SDPP received 253 µg/kg aflatoxins, 6930 µg/kg fumonisins and 6% SDPP. The animals treated with mycotoxin co-contaminated diets showed an increase in AChE and BChE activities in peripheral...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycotoxin; Acetylcholinesterase; Brain; Spray-dried porcine plasma; Animal health.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300807
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Enzymatic and biochemical characterization of Bungarus sindanus snake venom acetylcholinesterase J. Venom. Anim. Toxins incl. Trop. Dis.
Ahmed,M; Latif,N; Khan,RA; Ahmad,A; Rocha,JBT; Mazzanti,CM; Bagatini,MD; Morsch,VM; Schetinger,MRC.
This study analyses venom from the elapid krait snake Bungarus sindanus, which contains a high level of acetylcholinesterase (AChE) activity. The enzyme showed optimum activity at alkaline pH (8.5) and 45ºC. Krait venom AChE was inhibited by substrate. Inhibition was significantly reduced by using a high ionic strength buffer; low ionic strength buffer (10 mM PO4 pH 7.5) inhibited the enzyme by 1. 5mM AcSCh, while high ionic strength buffer (62 mM PO4 pH 7.5) inhibited it by 1 mM AcSCh. Venom acetylcholinesterase was also found to be thermally stable at 45ºC; it only lost 5% of its activity after incubation at 45ºC for 40 minutes. The Michaelis-Menten constant (Km) for acetylthiocholine iodide hydrolysis was found to be 0.068 mM. Krait venom...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Inhibition; Krait; Ionic strength; Acetylthiocholine iodide; Bungarus sindanus; Snake venom.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000200014
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In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli J. Venom. Anim. Toxins incl. Trop. Dis.
Janardhan,Bhavya; Shrikanth,Vineetha M; Mirajkar,Kiran K; More,Sunil S.
Background : Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative treatment. In folk medicine, Azima tetracanthaLam. is usually used to treat snakebites. The present study aims to provide a scientific explanation for the use of this plant against snakebite. The extracts of shade dried leaves of A. tetracanthawere tested for in vitroinhibitory activity on toxic venom enzymes like phosphomonoesterase, phosphodiesterase, acetylcholinesterase, hyaluronidase etc. from Bungarus caeruleusandVipera russellivenoms.Results : The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Azima tetracantha; Antivenom; Krait; Viper; In vitro.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200318
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In vivo and in vitroeffects of fructose on rat brain acetylcholinesterase activity: an ontogenetic study Anais da ABC (AABC)
GUIMARÃES,CARINE A.; BIELLA,MAIRIS S.; LOPES,ABIGAIL; DEROZA,PEDRO F.; OLIVEIRA,MARIANA B.; MACAN,TAMIRES P.; STRECK,EMILIO L.; FERREIRA,GUSTAVO C.; ZUGNO,ALEXANDRA I.; SCHUCK,PATRÍCIA F..
Increased fructose concentrations are the biochemical hallmark of fructosemia, a group of inherited disorders on the metabolic pathway of this sugar. The main clinical findings observed in patients affected by fructosemia include neurological abnormalities with developmental delay, whose pathophysiology is still undefined. In the present work we investigated the in vitro and in vivo effects of fructose on acetylcholinesterase (AchE) activity in brain structures of developing rats. For the in vitro experiments, fructose was added at increasing concentrations to the incubation medium. It was observed that fructose provoked an inhibition of acetylcholinesterase activity in cerebral cortex of 30-day-old-rats, even at low concentrations (0.1 mM). For the in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Brain; Fructosel hereditary fructose intolerance.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401919
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Low malathion concentrations influence metabolism in Chironomus sancticaroli (Diptera, Chironomidae) in acute and chronic toxicity tests Rev. Bras. entomol.
Rebechi,Débora; Richardi,Vinicius S.; Vicentini,Maiara; Guiloski,Izonete C.; Assis,Helena C. Silva de; Navarro-Silva,Mário A..
Low malathion concentrations influence metabolism in Chironomus sancticaroli (Diptera, Chironomidae) in acute and chronic toxicity tests. Organophosphate compounds are used in agro-systems, and in programs to control pathogen vectors. Because they are continuously applied, organophosphates often reach water sources and may have an impact on aquatic life. The effects of acute and chronic exposure to the organophosphate insecticide malathion on the midge Chironomus sancticaroli are evaluated. To that end, three biochemical biomarkers, acetylcholinesterase (AChE), alpha (EST-α) and beta (EST-β) esterase were used. Acute bioassays with five concentrations of malathion, and chronic bioassays with two concentrations of malathion were carried out. In the acute...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Bioindicator; Esterases; Organophosphate; Toxicity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262014000300012
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