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Registros recuperados: 14
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Acetylcholinesterase activity in the pons and medulla oblongata of rats after chronic electroconvulsive shock BJMBR
Camarini,R.; Benedito,M.A.C..
An imbalance between cholinergic and noradrenergic neurotransmission has been proposed for the etiology of affective disorders. According to this hypothesis, depression would be the result of enhanced cholinergic and reduced noradrenergic neurotransmission. Repeated electroconvulsive shock (ECS) is an effective treatment for depression; moreover, in laboratory animals it induces changes in brain noradrenergic neurotransmission similar to those obtained by chronic treatment with antidepressant drugs (down-regulation of beta-adrenergic receptors). The aim of the present study was to determine whether repeated ECS in rats changes acetylcholinesterase (Achase) activity. Achase controls the level of acetylcholine (Ach) in the synaptic cleft and its levels seem...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Medulla oblongata; Pons; Chronic electroconvulsive shock.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000012
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Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders Biol. Res.
Ahmad,Sajjad; Ullah,Farhat; Ayaz,Muhammad; Sadiq,Abdul; Imran,Muhammad.
BACKGROUND: Rumex species are traditionally used for the treatment of neurological disorders including headache, migraine, depression, paralysis etc. Several species have been scientifically validated for antioxidant and anticholinestrase potentials. This study aims to investigate Rumex hastatus D. Don crude methanolic extract, subsequent fractions, saponins and flavonoids for acetylcholinestrase, butyrylcholinestrase inhibition and diverse antioxidant activities to validate its folkloric uses in neurological disorders. Rumexhastatus crude methanolic extract (Rh. Cr), subsequent fractions; n-hexane (Rh. Hex), chloroform (Rh. Chf), ethyl acetate (Rh. EtAc), aqueous fraction (Rh. Aq), crude saponins (Rh. Sp) and flavonoids (Rh. Fl) were investigated against...
Tipo: Journal article Palavras-chave: Ethnomedicinal; Acetylcholinesterase; Butyrycholinesterase; DPPH; ABTS.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100020
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Characterization of acetylcholinesterase from the brain of the Amazonian tambaqui (Colossoma macropomum) and in vitro effect of organophosphorus and carbamate pesticides. Repositório Alice
ASSIS, C. R. D.; CASTRO, P. F. de; AMARAL, I. P. G.; CARVALHO, E. V. M. M.; CARVALHO JUNIOR, L. B.; BEZERRA, R. S..
2010
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Organophosphorus pesticide; Carbamate pesticide; Acetylcholinesterase; Biomarkers.
Ano: 2010 URL: http://www.alice.cnptia.embrapa.br/handle/doc/871124
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Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions BJMBR
Camarini,R.; Benedito,M.A.C..
Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic neurotransmission. In order to identify possible changes in cholinergic neurotransmission we measured total, membrane-bound and soluble acetylcholinesterase (Achase) activity in several rat brain regions after chronic imipramine treatment. Changes in Achase activity would indicate alterations in acetylcholine (Ach) availability to bind to its receptors in the synaptic cleft. Male rats were treated with imipramine (20 mg/kg, ip) for 21 days, once a day. Twenty-four hours after the last dose the rats were sacrificed and homogenates from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Imipramine; Brain; Antidepressants.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800007
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Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae) Biol. Res.
Dzoyem,Jean P.; Tsamo,Armelle T.; Melong,Raduis; Mkounga,Pierre; Nkengfack,Augustin E.; McGaw,Lyndy J.; Eloff,Jacobus N..
BACKGROUND: Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric oxide (NO) and acetylcholinesterase (AChE) inhibitory activity and the cytotoxicity of three limonoids: trichilia lactone D5 (1), rohituka 3 (2) and dregeanin DM4 (3), isolated from Trichilia welwitschii C.DC RESULTS: Results indicated that the three limonoids had low cytotoxicity towards Vero cells with LC50 values ranging from 89.17 to 75.82 (μg/L. Compounds (2) and (3) had lower cytotoxicity compared to puromycin and doxorubicin...
Tipo: Journal article Palavras-chave: Trichilia welwitschii; Cytotoxicity; Acetylcholinesterase; Nitric oxide; Limonoids.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100057
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Ecotoxicity assessment of functionalized activated charcoal on the activity of the enzyme acetylcholinesterase and its effect in the presence of pesticides. Repositório Alice
VIANNA, M.; NOVOTNY, E. H.; SILVA, T. S.; RIBEIRO, B. R.; DITTZ, L. A..
The study of soil organic matter of the "Terras Pretas de Índios" showed an efficient compost model for improving the physical chemistry properties of the soil. The charred materials have the condensed aromatic structures but it does not provide carboxylic groups, that are important for its reactivity and its contribution to soil CEC. The objective of this study is to evaluate the ecotoxicity of functionalized charcoal compounds (humic acids like material - HALM) through its sub-lethal kinetic behaviour of the enzyme AChE even in the presence of pesticides. Activated charcoal was chemically oxidized using sodium hypochlorite. Brains of rats were used for ecotoxicity assay. The IC (half maximal inhibitory concentration) for AChE was 65 mg L-1 of HALM. The...
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Biochar; Acetilcolinesterase; Ecotoxicidade; Pesticida; Toxicidade; Pesticides; Acetylcholinesterase; Ecotoxicology.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1001331
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Effect of Dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) Brain. Repositório Alice
ASSIS, C. R. D.; AMARAL, I. P. G.; CASTRO, P. F.; CARVALHO JÚNIOR, L. B.; BEZERRA, R. S..
Dichlorvos is an acutely toxic organophosphorous pesticide that is known as a classical acetylcholinesterase (AChE; EC 3.1.1.7) inhibitor. Here, the brain AChE from the important Amazonian fish tambaqui (Colossoma macropomum) was assayed in the presence of this insecticide and also of deltamethrin, a classical sodium and potassium channel inhibitor (negative control). Four tissue homogenates were analyzed in triplicate for AChE activity using acetylthiocholine as the substrate and 5,5'-dithiobis(2-nitrobenzoic) acid (DTNB) as the color-developing agent. Each tissue homogenate represented pooled brains from five fish. The inhibitory effect of dichlorvos on AChE activities was determined at concentrations from 0.001 to 10 ppm and compared to controls. This...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Organophosphorous pesticide; Dichlorvos; Biomarker; Acetylcholinesterase; Tambaqui; Colossoma macropomum.
Ano: 2007 URL: http://www.alice.cnptia.embrapa.br/handle/doc/69727
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Effect of oral exposure to the acaricide pirimicarb, a new varroacide candidate, on apis mellifera feeding rate ArchiMer
Riva, Clemence; Sokolowski, Michel B. C.; Normand, Julien; Santos, Jana Sopkova-de Oliveira; Halm-lemeille, Marie-pierre.
BACKGROUND The ectoparasitic honey bee mite Varroa destructor is one of the main causes related to the gradual decline of honey bees Apis mellifera. Nowadays, beekeepers utilize a wide range of different synthetic acaricides, organic acids and essential oils to keep mite populations under control. A previous work had shown that pirimicarb could be a new varroacide candidate. The aim of this study was to observe the chronic effects on worker honey bees feeding activity after an oral exposure to 1.05 mM of pirimicarb. Long-term effect of a 24 hours exposition to pirimicarb were also tested. RESULTS After three successive trials were performed, no mortality could be detected at the tested concentration, oral exposure to pirimicarb had significant effect on...
Tipo: Text Palavras-chave: Apis mellifera; Varroa destructor management; Acaricide; Pirimicarb; Acetylcholinesterase.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00423/53466/54362.pdf
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Natural factors to consider when using acetylcholinesterase activity as neurotoxicity biomarker in Young-Of-Year striped bass (Morone saxatilis) ArchiMer
Durieux, Eric; Farver, Thomas B.; Fitzgerald, Patrick S.; Eder, Kai J.; Ostrach, David J..
Acetylcholinesterase (AChE) activity is one of the most common biomarkers of neurotoxicity used in aquatic organisms. However, compared to its extensive use as biomarker, the effects of natural factors onAChE activity remain unclear especially in estuarine fishes. The aim of this study was to evaluate the effects of natural factors on AChE activity of striped bass (Morone saxatilis) juveniles. Brain AChE activity was measured in YOY (Young-Of-Year) individuals collected monthly from August 2007 to January 2008 at 12 different sites in the San Francisco Estuary system. The spatio-temporal variability of AChE was analyzed relative to water temperature and salinity as well as fish size. AChE activity was highly positively correlated with water temperature and...
Tipo: Text Palavras-chave: Fish; Biomarker; Acetylcholinesterase; Brain; Temperature; Salinity; Size.
Ano: 2011 URL: http://archimer.ifremer.fr/doc/00008/11939/8642.pdf
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Phytochemical Profile and Qualification of Biological Activity of an Isolated Fraction of Bellis perennis Biol. Res.
Costa Marques,Thiago H; Santos De Melo,Cassio H; Fonseca De Carvalho,Rusbene B; Costa,Luciana M; De Souza,Alexandre A; David,Jorge M; De Lima David,Juceni P; De Freitas,Rivelilson M.
This study describes the isolation and identification of apigenin-7-O-ghicopyranoside, a flavonoid isolated from the flowers of Bellis perennis L., Asteraceae, an species with a broad spectrum of biological activities. The in vitro antioxidant activity and the inhibition of the enzyme acetylcholinesterase were evaluated. The flavonoid showed strong in vitro antioxidant potential, because of the capacity of removal of hydroxyl radicals and nitric oxide, and also prevented the formation of thiobarbituric acid-reactive substances. These parameters were inhibited at the highest concentration of ApG at rates of 77.7%, 72% and 73.4%, respectively, in addition to inhibiting acetylcholinesterase, suggesting potential use in the treatment of neurodegenerative...
Tipo: Journal article Palavras-chave: Acetylcholinesterase; Antioxidant; Bellis perennis; Flavonoid.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300002
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Rapid Bioassay of Pesticide Residues (RBPR) on Fruits and Vegetable Taiwan Agricultural Research Institute
C.S. Chiu;C.H. Kao;E.Y. Cheng; 邱紀松;高靜華;鄭允.
[[abstract]]A RBPR (Rapid Bioassay for Pesticide Residues) method is developed by TARI in integrating the AChE test and B.t. test to screen the residues of acetyl-cholinesterase-inhibiting (neurotoxic) insecticides, EBDC´s (ethylene bisdithiocarbamates, the ETU-producing chemicals) and other B.t. inhibiting fungicides on fruits and vegetables. The RBPR (1) can complete the examination of a batch of 50 vegetable samples within 3 hrs or even faster, (2) provides toxicological indication on plants sample with residue of organophosphates, carbamates, EBDC´s and other detectable fungicides, and (3) is extremely economic and the material costs only ca. N.T.$ 4.0 (= U.S.$ 0.15) per test. The sensitivities of RBPR to 20 organophosphorus compounds, 2 carbamates and...
Palavras-chave: Rapid bioassay; Insecticide; Fungicide; Ethylene bisdithiocarbamates; Acetylcholinesterase; Bacillus thuringiensis; Pesticide residues 快速檢驗; 殺虫劑; 殺菌劑; 有機硫磺劑; 蘇力菌; 乙醯膽碱酯酶; 殘毒 [[classification]]5.
Ano: 1991
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Rapid eye movement (REM) sleep deprivation reduces rat frontal cortex acetylcholinesterase (EC 3.1.1.7) activity BJMBR
Rapid eye movement (REM) sleep deprivation induces several behavioral changes. Among these, a decrease in yawning behavior produced by low doses of cholinergic agonists is observed which indicates a change in brain cholinergic neurotransmission after REM sleep deprivation. Acetylcholinesterase (Achase) controls acetylcholine (Ach) availability in the synaptic cleft. Therefore, altered Achase activity may lead to a change in Ach availability at the receptor level which, in turn, may result in modification of cholinergic neurotransmission. To determine if REM sleep deprivation would change the activity of Achase, male Wistar rats, 3 months old, weighing 250-300 g, were deprived of REM sleep for 96 h by the flower-pot technique (N = 12). Two additional...
Tipo: Info:eu-repo/semantics/other Palavras-chave: REM sleep deprivation; Frontal cortex; Acetylcholinesterase.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000500012
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Teste de inibição da enzima acetilcolinesterase de compostos organofosforados com potencial ação fungicida na cultura de mamão (Carica papaya L.). Infoteca-e
BARBOZA, H. T. G.; SOARES, A. G.; FONSECA, M. J. de O.; DACOSTA, J. B. N.; SARQUIS, M. I. de M..
2010
Tipo: Documentos (INFOTECA-E) Palavras-chave: Atividade fungicida; Composto organofosforado; Acetilcolinesterase; Composto orgânico; Enzima; Organophosphorus compounds; Acetylcholinesterase.
Ano: 2010 URL: http://www.infoteca.cnptia.embrapa.br/handle/doc/874607
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The impact of insecticide resistance on Culex pipiens immunity ArchiMer
Vezilier, Julien; Nicot, Antoine; De Lorgeril, Julien; Gandon, Sylvain; Rivero, Ana.
Because of their role as vectors of diseases, the evolution of insecticide resistance in mosquitoes has been intensively investigated. Insecticide resistance is associated to a wide range of pleiotropic effects on several key life-history traits of mosquitoes such as longevity and behavior. However, despite its potential implications in pathogen transmission, the effects of insecticide resistance on mosquito immunity have received little, if any, attention. Here, we investigate the impact of insecticide resistance in Culex pipiens, an epidemiologically important vector of a wide array of pathogens. Using both isogenic laboratory strains and field-caught mosquitoes, we investigate the impact of two main insecticide resistance mechanisms (metabolic...
Tipo: Text Palavras-chave: Acetylcholinesterase; Anopheles; Antimicrobial peptide; Carboxylesterases; Nitric oxide; Transferrin.
Ano: 2013 URL: http://archimer.ifremer.fr/doc/00136/24773/22845.pdf
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