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Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 4
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Imprime registro no formato completo
Anticancer and apoptosis-inducing activities of microbial metabolites Electron. J. Biotechnol.
Phonnok,Sirinet; Uthaisang-Tanechpongtamb,Wanlaya; Wongsatayanon,Benjamas Thanomsub.
The problems of systemic toxicity and drug resistance in cancer chemotherapy urge the continuing discovery of new anticancer agents. We explored the specific anticancer activity from microbial metabolites to find new lead compound. 394 microbial extracts were evaluated on anti-proliferative activity against 4 cancer cell lines using MTT assay. Of these, 20 samples showed varying degree of cytotoxicity but specifically to the cancer cell lines since the growth of normal cells was not significantly inhibited by 1 mg/ml of each cell extracts. The 4 most potent extracts exhibited strongest growth inhibition to each cancer cell type were selected for further studied. Cell morphological changes such as cell shrinkage, lose of surface contact and blebbing were...
Tipo: Journal article Palavras-chave: Anticancer; Apoptosis; Bioactive compound; Caspase; Microbial product.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000500001
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Psidium cattleianum fruits: A review on its composition and bioactivity. Repositório Alice
PEREIRA, E. dos S.; VINHOLES, J.; FRANZON, R. C.; DALMAZO, G.; VIZZOTTO, M.; NORA, L..
bitstream/item/181667/1/Marcia-Vizzotto-Food-Chemistry-araca-review.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Antidiabetic; Anticancer; Antimicrobial; Anti-inflammatory; Anti-aging; Araçá; Antioxidante; Chemical composition.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1094287
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Stone Fruits as a Source of Bioactive Compounds. Repositório Alice
VINHOLES. J.; GELAIN, D. P.; VIZZOTTO, M..
2016
Tipo: Capítulo em livro científico (ALICE) Palavras-chave: Almond; Anticancer; Antidiabetic; Antiinflammatory; Antioxidant; Apricot; Bioactive Compounds; Cardiovascular protection; Cherry; Flavonoids; Nectarine; Obesity; Peach; Phenolic acids; Phenolic compounds; Plum; Prunus; Stone fruits.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1067684
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Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case study Biol. Res.
Repsold,Lisa; Mqoco,Thandi; Wolmarans,Elize; Nkandeu,Sandra; Theron,Joji; Piorkowski,Tomek; du Toit,Peet; van Papendorp,Dirk; Joubert,Annie Margaretha.
BACKGROUND: Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). These compounds were designed to have improved bioavailability when compared to their source compound, 2-methoxyestradiol. This theoretically would be due to their increased binding affinity to carbonic anhydrase II, present in erythrocytes. Since the novel compounds under investigation are proposed to be transported within erythrocytes bound to carbonic anhydrase II, the morphological effect which they may exert on whole blood and erythrocytes is of great significance. A secondary outcome included revision of previously...
Tipo: Journal article Palavras-chave: Whole blood; Morphology; ESE-15-ol; ESE-16; Anticancer; Erythrocytes.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100039
Registros recuperados: 4
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