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Assessment of Leishmania major and Leishmania braziliensis promastigote viability after photodynamic treatment with aluminum phthalocyanine tetrasulfonate (AlPcS4) J. Venom. Anim. Toxins incl. Trop. Dis.
JG,Pinto; CP,Soares; J,Mittmann.
Cutaneous leishmaniasis is an infectious disease caused by protozoans of the genus Leishmania, which is transmitted through the bite of hematophagous insects of the genus Lutzomyia. This study aimed at testing in vitro the phototoxic effect of aluminum phthalocyanine tetrasulfonate (AlPcS4) on the viability of Leishmania major and Leishmania braziliensis. Stationary phase promastigote forms were treated with AlPcS4 at 1.0 µM and 10.0 µM and incubated for one hour. Then 659 nm laser was applied at 5 and 10 J/cm². Parasite viability was determined by differential count using the trypan blue dye exclusion method and by monitoring growth curves for nine days. Trypan blue exclusion assay showed a significant reduction of viable parasites compared to controls,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cutaneous leishmaniasis; Antiparasitic agents; Leishmania major; Leishmania braziliensis; AlPcS4; Photodynamic therapy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300010
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Evaluation of the toxicity of the mixture of diflubenzuron and p-chloroaniline in tilapia fish in the presence and absence of soil. Repositório Alice
DANTZGER, D. D.; JONSSON, C. M.; NUNES, A. A. S.; AOYAMA, H..
aBSTRACT: Several chemicals occur together in the environment as a result of different sources. However, in the great majority of risk assessments only a single chemical is considered. Diflubenzuron (DFB), the most used compound to combat parasites in aquaculture, can be toxic for non-target species. When degraded, it generates p-chloroaniline (PCA), a potentially carcinogenic and mutagenic compound. This study analyzed the activity of the enzymes: Catalase (CAT), acid and alkaline Phosphatase (ACP/ALP) of the gills of the Tilapia fish (Oreochromis niloticus) exposed to different concentrations of the mixture of DFB and PCA in the presence and absence of soil.
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: P-chloroaniline; Phosphatases; Soil; Aquicultura; Agrotóxico; Impacto ambiental; Toxidez; Tilápia nilótica; Aquaculture; Diflubenzuron; Catalase; Antiparasitic agents; Ecotoxicology.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1064401
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Las esponjas marinas como fuente de nuevas sustancias bioactivas. OceanDocs
Regalado, E.L.; Laguna, A.; Martínez, J.R..
Marine sponges (Porifera) have drawn the attention from a broad number of researchers all over the world. These animals and their simbionts are specialized in chemical warfare, producing biologically active chemical substances as an effective defense against predators. They have been considered a goldmine to chemists, from which have been discovered more than 6000 novel structures; many of them, with enormous biomedical applications, mainly against cancer, but also against bacteria, viruses and other diseases. Some of the sponge-derived drugs are available in the market, such as: Ara-A (antiviral) and Ara-C (anticancer), but there are diverse bioactive compounds under clinical trials. In Cuba, the researches related to the isolation of compounds from...
Tipo: Journal Contribution Palavras-chave: Sponges; Organic compounds; Antiparasitic agents.
Ano: 2010 URL: http://hdl.handle.net/1834/4129
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