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Registros recuperados: 5
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Autoimmune diseases in the TH17 era BJMBR
Mesquita Jr.,D.; Cruvinel,W.M.; Câmara,N.O.S.; Kállas,E.G.; Andrade,L.E.C..
A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoimmune diseases; Cytokines; TH17 cells; IL-17; IL-22; IL-23.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600002
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Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor BJMBR
Yoon,S.; Hirata,R.D.C.; Nguyen,N.Y.; Curi,R.; Russo,M.; Hirata,M.H..
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a. IFN-a can contribute to the pathogenesis of allograft rejection in bone marrow transplants. Therefore, the development of IFN-a inhibitors as a soluble receptor protein may be valuable for the therapeutic control of these diseases. We have expressed two polypeptides encoding amino acids 93-260 (P1) and 261-410 (P2) of the extracellular domain of subunit 1 of the interferon-a receptor (IFNAR 1-EC) in E. coli. The activities of the recombinant polypeptides and of their respective antibodies were evaluated using antiproliferative and antiviral assays. Expression of P1 and P2 polypeptides was achieved by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Interferon alpha; Interferon-a receptor; Inhibitor of interferon-a; Autoimmune diseases; Graft-versus-host disease; Recombinant protein.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700007
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Follicular helper T cell in immunity and autoimmunity BJMBR
Mesquita Jr,D.; Cruvinel,W.M.; Resende,L.S.; Mesquita,F.V.; Silva,N.P.; Câmara,N.O.S.; Andrade,L.E.C..
The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh). These new subsets have many features in common, such as the ability to produce IL-21 and to express the IL-23 receptor (IL23R), the inducible co-stimulatory molecule ICOS, and the transcription factor c-Maf, all of them essential for expansion and establishment of the final pool of both subsets. Tfh cells differ from Th17 by their ability to home to B cell areas in secondary lymphoid tissue through interactions mediated by the chemokine receptor CXCR5 and its ligand CXCL13. These CXCR5+ CD4+ T cells are...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoimmune diseases; Tfh; Lymphoid tissue; Humoral immunity.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500302
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Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis BJID
Seyyedi,Noorossadat; Dehbidi,Gholamreza Rafiei; Karimi,Mozhgan; Asgari,Amir; Esmaeili,Babak; Zare,Farahnaz; Farhadi,Ali; Dabbaghmanesh,Mohammad Hossein; Saki,Forough; Behzad-Behbahani,Abbas.
ABSTRACT Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases. Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated. Methods:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human herpesvirus 6; Prevalence; Hashimoto disease; Autoimmune diseases.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435
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Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review Biol. Res.
Figueroa,Fernando E; Carrión,Flavio; Villanueva,Sandra; Khoury,Maroun.
Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohn's disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future...
Tipo: Journal article Palavras-chave: Mesenchymal stem cells; Autoimmune diseases; Cellular therapy.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008
Registros recuperados: 5
Primeira ... 1 ... Última
 

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