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An Ag-dependent approach based on adaptive mechanisms for investigating the regulation of the memory B cell reservoir. Repositório Alice
CASTRO, A. de..
In fact, it is well-known that the soluble antibody population is one of the essential mechanisms of immunological response regulation [23-25]. However, despite the pioneering work of Lagreca et al. (2001) in developing a coupled map for studying the behavior of the mammalian immune system, their model did not consider these populations [1-6], which makes the model incomplete with respect to the regulation of the immune response by adaptive mechanisms. This omission opens up the possibility of extending their work by taking the soluble antibody populations into account. We have performed that work and present our immunological modeling and simulation findings in this paper.
Tipo: Capítulo em livro científico (ALICE) Palavras-chave: Modelo dinâmico; Modelo de simulação; Modelo matemático; Simulação dinâmica; Células B; Dynamic models; Simulation models; Mathematical models.
Ano: 2012 URL: http://www.alice.cnptia.embrapa.br/handle/doc/924382
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Computational approach of the homeostatic turnover of memory B cells. Repositório Alice
CASTRO, A. de; FRONZA, C. F.; ANSELMO, J..
In this paper, a discrete mathematical model inspired by control mechanisms is used to explore the factors potentially responsible for maximum immunization capacity in mammals. The results have been discussed in light of recent work, and refer to the adoption of parameter values chosen among data gathered from the literature. The model used in this study took into consideration that the immune system is a network of molecules and cells that can recognize itself.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Células B; Memória imune; Immune memory; Homeostatic turnover; Equilíbrio homeostático; Modelo matemático; Mathematical models; Memory.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/999572
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In silico approach for viral mutations and sustainability of immunizations. Repositório Alice
CASTRO, A. de.
In this paper we use virtual samples of individuals and a dynamical modeling proposed in a previous study to study the behavior of immune memory against antigenic mutation.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Memória imunológica; Imunologia computacional; Estocasticidade; Mutação viral; Células B; Vacina; Immune memory; Computational immunology; Viral mutation; Stochasticity; B cells; Imunologia; Mutação; Immunology; Immunologic memory; Mutation; Stochastic processes; Vaccines.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1030086
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