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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Latifimoghadam,Mohammad Hossein; Kaboli,Sakineh.
Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days...
Tipo: Journal article Palavras-chave: Diabetes; Astrocyte; Urtica dioica; Dentate gyrus.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039
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Atuação do Vegf na placenta de ratas diabéticas induzidas por aloxana MV&Z
S. Farias, Priscilla; dos S. Souza, Karine; T. Fioretto, Emerson; B. Aires, Marlúcia.
A diabetes mellitus gestacional ocorre em cerca de 7% de todas as gestações,resultando em mais de 200.000 casos/ano. Os distúrbios hiperglicêmicosassociados a essa condição levam a alterações da estrutura e função da placenta o que acarreta problemas na transferência de nutrientes entre mãe e feto. O objetivo do trabalho foi avaliar o perfil glicêmico, ganho de peso materno, e expressão de VEGF em placentas de ratas Wistar diabéticas. Foram utilizadas ratas no 8º dg para aplicação de aloxana ou solução salina. O peso corporal e a glicemia foram avaliados no 8º dg e 17º dg. No 17º dg os animais foram anestesiados e laparotomizados para coleta das placentas. Foi realizada análise histológica e imunocitoquímica para VEGF. A aplicação de aloxana foi capaz de...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Gestação; Imunocitoquímica; VEGF; Placenta.
Ano: 2014 URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/23719
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Ausentismo laboral y factores de riesgo cardiovascular en empleados públicos hospitalarios ABCL
Castillo Rascón,María Susana; Castro Olivera,Carlos; Sánchez,Augusto; Ceballos,Blanca Haydee; Pianesi,María Ester; Malarczuk,Cristina; Bonneau,Graciela Alicia; Albrekt,Ana Lía; Bollati,Estela; Sánchez,Andrea.
El objetivo del presente trabajo fue determinar el ausentismo laboral por enfermedad según causalidad y su relación con edad, sexo, nivel de instrucción, ocupación y factores de riesgo cardiovascular en empleados públicos hospitalarios. La cohorte de estudio estuvo constituida por 270 trabajadores de dos hospitales públicos de Posadas, Misiones, seguidos desde el año 2002 al 2012. Se realizaron encuestas personales, mediciones antropométricas, de presión arterial y extracciones sanguíneas para las determinaciones bioquímicas. Se utilizó el modelo de riesgos proporcionales de Cox, usando como variable dependiente el ausentismo laboral. La Mediana de ausentismo fue de 2 días por año (Percentilo25:0,0-Percentilo75:9,75). Las enfermedades osteoarticulares y la...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ausentismo laboral; Trabajadores de salud; Edad; Sexo; Ocupación; Nivel de instrucción; Diabetes; Hipertensión arterial; Hipercolesterolemia.
Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000100007
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Biomarcadores emergentes para diferentes patologías humanas ABCL
Marra,Carlos Alberto; Tacconi de Alaniz,María Josefa.
El objetivo de esta actualización fue revisar los hallazgos concernientes a la posible utilidad clínica de nuevos biomarcadores de estrés oxidativo-nitrosativo, especialmente aquellos derivados del metabolismo lipídico, como herramientas a implementar en el diagnóstico diferencial, la prognosis, el riesgo o la evaluación de estrategias terapéuticas, en enfermedades crónicas de tipo degenerativo. Se analizó la información disponible sobre el uso de marcadores emergentes en casos de infertilidad masculina por varicocele, pacientes con neurodegeneración debida a mal de Alzheimer, de Parkinson, o demencias de origen vascular, enfermos con cáncer de pulmón, próstata o mama, diabéticos tipo 2 y personas expuestas a agroquímicos en forma profesional. Como...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biomarcadores; Lípidos; Diabetes; Cáncer; Pesticidas; Estrés oxidativo; Varicocele.
Ano: 2013 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572013000200013
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Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats. Repositório Alice
ALMEIDA, M. M. de; LUQUETTI, S. C. P. D.; SABARENSE, C. M.; CORRÊA, J. O. do A.; REIS, L. G. dos; CONCEIÇÃO, E. P. S. da; LISBOA, P. C.; MOURA, E. G. de; GAMEIRO, J.; GAMA, M. A. S. da; LOPES, F. C. F.; GARCIA, R. M. G..
Feeding rats on a high-fat diet containing butter naturally enriched in cis-9, trans-11 CLA prevented hyperinsulinemia and increased HDL cholesterol, which could be associated with higher levels of cis-9, trans-11 CLA, vaccenic acid, oleic acid and lower levels of short and medium-chain saturated fatty acids from butter naturally modified compared to control butter. On the other hand CLA-enriched butter also increased serum triacylglycerol levels, which could be associated with concomitant increases in the content of trans-9 and trans-10 C18:1 isomers in the CLA-enriched butter.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: High conjugated linoleic acid enriched butter; Functional food; Rats; Insulin sensitivity; Dyslipidemia; Diabetes.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1006276
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Caracterização fisica e química de abóbora Cucurbita ficifolia Bouché cultivada em Brasília-DF: uma potencial hortaliça para tratamento da diabetes mellitus tipo 2. Repositório Alice
MUNIZ, L. B.; PINTO, J. V.; MATTOS, L. M.; MORETTI, C. L..
Objetivou-se caracterizar química e fisicamente, a espécie domesticada de abóbora C. ficifolia Bouché cultivada em Brasília-DF, uma vez que há relatos na literatura quanto seu potencial efeito hipoglicemiante na diabetes mellitus tipo 2.
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Diabetes; Abóbora; Cucurbita moschata.
Ano: 2012 URL: http://www.alice.cnptia.embrapa.br/handle/doc/930083
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Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats Braz. J. Vet. Res. Anim. Sci.
MORAES,Julieta Rodini Engrácia de; MORAES,Flávio Ruas de; ENGRÁCIA FILHO,Jair Rodini.
We investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chloramphenicol; Diabetes; Pleurisia; Neutrophils.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95961998000600002
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Constitutive nitric oxide synthase (cNOS) activity in Langerhans islets from streptozotocin diabetic rats BJMBR
Fonovich de Schroeder,T.M.; Carattino,M.D.; Frontera,M.; Catanzaro,O.L..
Nitric oxide synthase activity was measured in Langerhans islets isolated from control and streptozotocin diabetic rats. The activity of the enzyme was linear up to 150 µg of protein from control rats and was optimal at 0.1 µM calcium, when it was measured after 45 min of incubation at 37oC in the presence of 200 µM arginine. Specific activity of the enzyme was 25 x 10-4 nmol [3H]citrulline 45 min-1 mg protein-1. Streptozotocin diabetic rats exhibited less enzyme activity both in total pancreas homogenate and in isolated Langerhans islets when compared to control animals. Nitric oxide synthase activity measured in control and diabetic rats 15 days after the last streptozotocin injection in the second group of animals corresponded only to a constitutive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide synthase; Nitric oxide; Langerhans islets; Streptozotocin; Diabetes.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500004
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Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice Biol. Res.
Soto-Urquieta,María G; López-Briones,Sergio; Pérez-Vázquez,Victoriano; Saavedra-Molina,Alfredo; González-Hernández,Gloria A; Ramírez-Emiliano,Joel.
BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice. RESULTS: Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or...
Tipo: Journal article Palavras-chave: Diabetes; Mitochondria; Curcumin; ATPase activity; Nitric oxide synthesis; Lipid oxidation.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100068
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Diabetic Peripheral Neuropathies: A Morphometric Overview International Journal of Morphology
Fazan,Valéria Paula Sassoli; Vasconcelos,Carlos Augusto Carvalho de; Valença,Marcelo Moraes; Nessler,Randy; Moore,Kenneth Charles.
Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the disease may be useful as they allow the recognition of the early mechanisms involved in the long-term complications of diabetes. Peripheral nerve involvement is highly frequent in diabetes mellitus and it has been documented that one third of diabetic patients have peripheral neuropathy. The true prevalence is not known and reports vary from 10% to 90% in diabetic...
Tipo: Journal article Palavras-chave: Diabetes; Experimental models; Neuropathy; Morphometry.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100007
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Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? Biol. Res.
Ortiz,Gustavo; Salica,Juan P; Chuluyan,Eduardo H; Gallo,Juan E.
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell damage that affects the retinal circulation. In turn, this causes hypoxia leading to release of vascular endothelial growth factor (VEGF) to induce the angiogenesis process. Alpha-1 antitrypsin (AAT) is the most important circulating inhibitor of serine proteases (SERPIN). Its targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, proteinase 3 (PR-3) and plasminogen activator (PAI). AAT modulates the effect of protease-activated receptors (PARs) during inflammatory responses. Plasma levels of AAT...
Tipo: Journal article Palavras-chave: Diabetic retinopathy; Alpha-1-antitrypsin; Diabetes; Endogenous anti-inflammatory agents; Retinal inflammation; NF-kB.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100052
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Does Diabetes Alter Immunolocalization of Galectin-1 and Galectin-3 in the Rat Ovary? International Journal of Morphology
Özdenoglu,Berna; Saraydin,Serpil Ünver.
Diabetes mellitus (DM), is a metabolic disease occurring via insulin secretion deficiency from the pancreas and/or an insufficiency of tissue response to insulin. The present study is intended to show of immunolocalizations of beta-galactose-binding proteins Galectin-1 and Galectin-3 in diabetic rat ovarium and their relationship with diabetes. In this study, 8 to 10-week-old, 250­300 g weighing 50 mature female rats were used, in order to establish diabetes mellitus in those animals, 60 mg/kg intravenous streptozotocin was injected to each animal. After death, diabetics and non-diabetics rats's routine tissue processing steps is done to rat ovarial tissues for immunohistochemical investigation. Strong expressions of Galectin-1 and Galectin-3 were observed...
Tipo: Journal article Palavras-chave: Galectin-1; Galectin-3; Ovary; Diabetes; Rat.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200050
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Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Farsi,Mir Mehrdad.
Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze...
Tipo: Journal article Palavras-chave: Diabetes; Urtica dioica; Liver; Hepatocyte; Morphometry.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058
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Emphysematous cystitis in a dog: case report radiographic MV&Z
da Silva, Debora Prado; do Lago, Elis Roberti Perlato; Alves, Jefferson Douglas Soares.
The urinary bladder infection, having glucose-fermentingmicroorganisms such as pathogens is the disease called asemphysematous cystitis. These microorganism are ableto produce balls of gas in the bladder lumen. The mostfrequent bacteria associated with this pathology are: Proteussp, Aerobacteraerogenous, Escherichia coli and Clostridiumspp. The causes are nonspecific and are usually secondary toseveral conditions as diabetes mellitus, hyperadrenocorticism,anatomical defects, urolithiasis, tumours, prolongedcorticosteroid therapy, bladder wall thickening caused by chronicinflammation, and not ruling out the possibility of reportsin dogs not diabetic. The clinical sings are also nonspecific:dysuria, hematuria, urinary frequency, abdominal pain,apathy....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cystitis; Micro Organism; Ultrasound; Radiography; Diabetes Cistite; Microrganismo; Ultrassonografia; Radiografia; Diabetes.
Ano: 2016 URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/28821
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Estudio etnofarmacológico de especies vegetales con actividad hipoglucemiante en la comunidad de Malpasito en Huimanguillo, Tabasco. Colegio de Postgraduados
Villarreal Ibarra, Edelia Claudina.
Ante el incremento de enfermedades crónico-degenerativas uno de los recursos terapéuticos por excelencia lo representa la medicina tradicional, la presente investigación documenta y evalúa farmacológicamente las plantas utilizadas para el control de la Diabetes Mellitus (DM) en la comunidad de Malpasito, dentro de la Reserva Ecológica de Agua Selva en Huimanguillo, Tabasco, México como un aporte a la validación científica. Registra un inventario del conocimiento tradicional de las plantas medicinales, con información sobre el uso terapéutico, forma de preparación y parte vegetal utilizada. La información se recabó mediante entrevistas estructuradas TRAMIL. Se registraron 128 especies distribuidas en 63 familias botánicas, los usos medicinales se agruparon...
Palavras-chave: Medicina tradicional; Diabetes; Citotoxicidad; Artemia salina; Traditional medicine; Cytotoxicity; Ciencias por Investigación; Doctorado.
Ano: 2014 URL: http://hdl.handle.net/10521/2278
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Evaluación de disfunción endotelial en pacientes con diabetes tipo 2 ABCL
Velarde,María Susana; Prado,María Mercedes; Carrizo,Teresita del Rosario; Abregú,Adela Victoria; Sánchez,Sara Serafina.
El objetivo de este trabajo fue estudiar moléculas involucradas en la activación endotelial, tales como la molécula de adhesión sE-Selectina (sE-S) y el péptido vasoconstrictor Endotelina-1 (ET-1) en individuos diabéticos tipo 2 y su asociación con otros factores de riesgo cardiovascular. Se estudiaron 62 pacientes diabéticos que se compararon con un grupo control. Las concentraciones de sE-S y ET-1 fueron significativamente mayores en los diabéticos que en los controles (sE-S: 90,6±26,2 ng/mL vs. 49,5±9,2 ng/mL, p<0,00001; ET-1: 11,3±3,7 vs. 7,7±0,5 pg/mL, p<0,001, respectivamente). Estas moléculas, en pacientes con índice de masa corporal (IMC) normal y aumentado, mostraron diferencias significativas (sE-S: 75,5±22,4 vs. 97,1±32,9 ng/mL, p<0,05;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Endotelio; Selectina; Endotelina.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572007000400006
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Evaluación de inhibidores fisiológicos de la coagulación en pacientes diabéticos tipo 2 ABCL
Lena,Ana; Raymondo,Stella.
La diabetes mellitus está asociada a disturbios en la hemostasis que pueden contribuir al desarrollo de enfermedad vascular diabética. El objetivo de este trabajo fue estudiar la coagulación en una población diabética de Uruguay y compararla con una población de referencia normal. Se trabajó con 100 pacientes diabéticos tipo 2, de ambos sexos (49 mujeres y 51 hombres), con edades comprendidas entre 42 y 79 años, y una población control representada por 130 individuos aparentemente sanos (73 mujeres y 57 hombres) cuyas edades oscilaron entre 37 y 78 años, los que fueron tomados como referencia. Se realizaron las determinaciones de tiempo de protrombina (TP), fibrinógeno (Fib), proteína C (PC), proteína S (PS), antitrombina III (ATIII) e inhibidor del...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Estado protrombótico; Hipercoagulabilidad; Enfermedad vascular.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572007000200004
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Evaluación de la toxicidad subcrónica de la variedad colombiana de Smallanthus sonchifolius (Yacón) en ratas hembra Acta Toxicol. Argent.
Rodríguez Espinosa,Jhon D; Torres Wilches,Miguel A.
Smallanthus sonchifolius (Yacón) es una planta usada comúnmente por largos periodos de tiempo con el fin de ayudar en el control de la diabetes y otros desordenes metabólicos, por lo que con el propósito de evaluar la toxicidad subcrónica de la variedad colombiana de esta planta, fueron tratadas 30 ratas hembra de 8 semanas de edad dividas en 6 grupos. A cada uno de ellos se administró durante 28 días una de las siguientes dosis de infusión acuosa liofilizada (500, 250 y 125 mg/kg de peso), evaluando paralelamente grupos control (positivo y negativo) e incluyendo entre ellos grupos con y sin dieta hipercalórica. Para el seguimiento del perfil metabólico de los animales, se tomaron muestras de sangre periódicamente durante el ensayo y se evaluaron los...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Smallanthus sonchifolius; Toxicidad subcrónica; Diabetes; Síndrome metabólico.
Ano: 2017 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432017000300003
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GUAR GUM EFFECTS ON BLOOD SERUM LIPIDS AND GLUCOSE CONCENTRATIONS OF WISTAR DIABETIC RATS1 Ciênc. Tecnol. Aliment.
DARIO FRIAS,Andrea; SGARBIERI,Valdemiro C..
The effects of guar gum derived from the endosperm of Cyamopsis tetragonoloba (75% soluble fiber, 7.6% insoluble fiber, 2.16% crude protein, 0.78% total lipids, 0.54% ash and 9.55% moisture) on diabetic rats were studied concerning food intake, body weight gain, blood serum cholesterol, triacylglycerols, glucose, LDL-, and HDL-cholesterol concentrations. The effect of gum on indexes of protein absorption and utilization was also investigated. Diets containing 0%, 10% and 20% (w/w) guar gum were fed to diabetic rats for 28 days. In spite of the fact that diabetes elevated blood lipids in all animals, guar gum diet significantly decreased (p &lt;0.05) serum concentrations of cholesterol and triacylglycerols. Furthermore, a concomitant increase in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Guar gum; Cholesterol; Glucose; Diabetes.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20611998000200018
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Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia International Journal of Morphology
Komolafe,O. A; Ofusori,D. A; Adewole,O. S; Ayoka,A. O; Bejide,R.
Diabetes mellitus (DM) is a serious metabolic disorder with micro and macro-vascular complications that result in a significant morbidity and mortality. The present study investigated the effects of Momordica charantia (M. charantia) on histological changes of the aorta and pulmonary trunk in streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats...
Tipo: Journal article Palavras-chave: Diabetes; Momordica charantia; Histological; Histochemistry; Aorta; Pulmonary trunk.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200060
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