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An Ag-dependent approach based on adaptive mechanisms for investigating the regulation of the memory B cell reservoir. Repositório Alice
CASTRO, A. de..
In fact, it is well-known that the soluble antibody population is one of the essential mechanisms of immunological response regulation [23-25]. However, despite the pioneering work of Lagreca et al. (2001) in developing a coupled map for studying the behavior of the mammalian immune system, their model did not consider these populations [1-6], which makes the model incomplete with respect to the regulation of the immune response by adaptive mechanisms. This omission opens up the possibility of extending their work by taking the soluble antibody populations into account. We have performed that work and present our immunological modeling and simulation findings in this paper.
Tipo: Capítulo em livro científico (ALICE) Palavras-chave: Modelo dinâmico; Modelo de simulação; Modelo matemático; Simulação dinâmica; Células B; Dynamic models; Simulation models; Mathematical models.
Ano: 2012 URL: http://www.alice.cnptia.embrapa.br/handle/doc/924382
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Fast and reliable calibration of solid substrate fermentation kinetic models using advanced non-linear programming techniques Electron. J. Biotechnol.
Araya,M. Macarena; Arrieta,Juan J; Pérez-Correa,J. Ricardo; Biegler,Lorenz T; Jorquera,Héctor.
Calibration of mechanistic kinetic models describing microorganism growth and secondary metabolite production on solid substrates is difficult due to model complexity given the sheer number of parameters needing to be estimated and violation of standard conditions of numerical regularity. We show how advanced non-linear programming techniques can be applied to achieve fast and reliable calibration of a complex kinetic model describing growth of Gibberella fujikuroi and production of gibberellic acid on an inert solid support in glass columns. Experimental culture data was obtained under different temperature and water activity conditions. Model differential equations were discretized using orthogonal collocations on finite elements while model calibration...
Tipo: Journal article Palavras-chave: Dynamic models; Gibberellic acid; Nonlinear models; Parameter estimation; Secondary metabolites; Solid substrate cultivation.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000100005
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Livestock Dynamics: An Old Problem and Some New Tools AgEcon
MacAulay, T. Gordon; Hertzler, Greg.
A problem encountered in the econometric estimation of dynamic models of livestock systems is dynamic instability during simulation of models. In the case of systems where economic decisions are involved in the breeding and the slaughter of animals it is possible for parameters to be obtained which generate dynamic instability. In the paper, a simple representation of the dynamics of a livestock system is examined using techniques of dynamic analysis. The dynamic stability of such models depends fundamentally on the parameters determining the births and deaths and thus the relative flows in and out of the stock of animals. In some situations very narrow stability ranges for the values of the parameters are observed.
Tipo: Presentation Palavras-chave: Dynamic models; Beef herd; Dynamic instability; Dynamic processes; Livestock Production/Industries.
Ano: 2000 URL: http://purl.umn.edu/123699
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