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Farnesol in combination with N-acetylcysteine against Staphylococcus epidermidis planktonic and biofilm cells BJM
Gomes,Fernanda; Leite,Bruna; Teixeira,Pilar; Azeredo,Joana; Oliveira,Rosário.
Staphylococcus epidermidis is the most frequent cause of nosocomial sepsis and catheter-related infections, in which biofilm formation is considered to be the main virulence mechanism. In biofilm environment, microbes exhibit enhanced resistance to antimicrobial agents. This fact boosted the search of possible alternatives to antibiotics. Farnesol and N-acetylcysteine (NAC) are non-antibiotic drugs that have demonstrated antibacterial properties. In this study, the effect of farnesol and NAC isolated or in combination (farnesol+NAC) was evaluated. NAC at 10 × MIC caused a total cell death in planktonic cells. On the other hand, S. epidermidis biofilms exhibited 4 log reduction in viable cell number after a 24h treatment with NAC at the former...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nosocomial infection; Biofilm; Staphylococci; Farnesol; N- acetylcysteine.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100026
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Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis Biol. Res.
WRIGHT,MARCIA M.; MCMASTER,CHRISTOPHER R..
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacylglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding...
Tipo: Journal article Palavras-chave: Apoptosis; Diacylglycerol; Farnesol; Phorbol ester; Protein kinase C.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200014
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