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PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects Inra
Villard, P.H.; Caverni, S.; Baanannou, A.; Khalil, A.; Martin, P.G.; Penel, C.; Pineau, T.; Seree, É.; Barra, Y..
In this work we demonstrate that Caco-2 cell treatment with WY-14643 (a potent PPARα agonist) causes an increase in AhR expression. Luciferase assays and directed mutagenesis experiments showed that induction mainly occurred at transcriptional level and involved a PPRE site located within the AhR promoter. These results were further confirmed by the use of PPARα knockout mice in which AhR induction by WY14643 was abrogated. In addition to CYP1 regulation, AhR has been described as being involved in inflammation, so we also studied the effect of AhR regulation by PPARα on the expression of some inflammation target genes. 3-Methylcholanthrene (a potent AhR agonist) increased the expression (mRNA) of the major inflammatory targets IL-1β and MMP9. WY-14643...
Tipo: Journal Article Palavras-chave: INFLAMMATION; AHR; PPARALPHA; GUT; CACO-2.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20079fb7485d&uri=/notices/prodinra1/2007/12/
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Recherches sur les corpuscules calcaires dans l'intestin de l'abeille National Institute of Agronomic Research
Fyg, W..
Tipo: Journal Article-postprint Palavras-chave: HONEYBEE; SOCIAL INSECT; APIS MELLIFERA; APIDAE; APOIDEA; HYMENOPTERA; POLLINATOR; GUT; CALCAREOUS CORPUSCLE; ABEILLE DOMESTIQUE; INSECTE SOCIAL; APIS MELLIFERA; APIDAE; APOIDEA; HYMENOPTERA; POLLINISATEUR; INTESTIN; CALCAIRE.
Ano: 1932 URL: http://hdl.handle.net/2174/300
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