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Age-Related Changes in the Expression of ICAM-1 in the Aorta of Wistar Albino Rats International Journal of Morphology
Ketani,Sennur; Karakoç,Zelal; Ketani,M. Aydin; Kilinç,Mehmet.
ICAM-1 which is expressed by endothelial cells and leukocytes are observed as first markers in diseases such as transplant rejection, diabetes and atherosclerosis and in infections caused by various pathogens. In the present study, it is aimed to reveal the age-related changes in the expression of ICAM-1 on rats. Therefore, a total of 30 albino rats were taken at the age of 6, 18 and 24 months without gender discrimination. Rats were fed with standard pellet feed during the study. Afterwards, rats were sacrificed and tissue samples were collected from their rats, and the samples were evaluated under the light microscope by staining with immnunohistochemical method. It was determined that the expression of both aortic endothelial cells and endothelial cells...
Tipo: Journal article Palavras-chave: ICAM-1; Rat; Aortic endothelium; Age.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400049
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Effect of antibodies to intercellular adhesion molecule type 1 on the protection of distant organs during reperfusion syndrome in rats BJMBR
Souza-Moraes,M.R.; David-Filho,R.; Baptista-Silva,J.C.C.; Ullian,M.; Franco,M.F.; Gabriel Jr.,A.; Smith,B.; Burihan,E..
We investigated kidney and lung alterations caused by intercellular adhesion molecule type 1 (ICAM-1) blockade after ischemia and reperfusion of hind limb skeletal muscles. Rats were submitted to ligature of the infrarenal aorta for 6 h. The animals were randomized into three groups of 6 rats each: group I, sacrificed after ischemia; group II, reperfusion for 24 h, and group III, reperfusion for 24 h after receiving monoclonal anti-ICAM-1 antibodies. At the end of the experiment, blood samples were collected for creatinine, lactate dehydrogenase, creatine phosphokinase, potassium, pH and leukocyte counts. Samples were taken from the muscles of the hind limbs and from the kidneys and lungs for histological analysis and measurement of the neutrophil...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ICAM-1; Neutrophil; Myeloperoxidase; Kidney; Lung; Reperfusion.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500007
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Evaluation of prognostic value of cell adhesion molecules in chronic hepatitis C therapy J. Venom. Anim. Toxins incl. Trop. Dis.
Abdallah,N; Morsi,M; Hamed,N; Abdel Aziz,H.
The most reliable determination of severity and prognosis in chronic viral hepatitis is the histological staging of the disease, which comprises an invasive procedure and is often not well accepted by patients. The search for alternative non-invasive methods is mandatory especially in follow-ups after initial assessment by biopsy. The aim of this study was to evaluate the role of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in patients under interferon alpha therapy whether responsive or non-responsive to therapy. Thirty chronic hepatitis C patients (CHC) under combined therapy of interferon-α with ribavirin, whether responsive or non-responsive, were included in the study as well as ten healthy controls. Serum...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ICAM-1; VCAM-1; Interferon; Ribavirin; Chronic hepatitis C.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300010
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Expresión de ICAM-1 en el Endotelio de Arterias Humanas Mediante Inmunohistoquímica International Journal of Morphology
Moore-Carrasco,Rodrigo; Donoso,Wendy; Sutin,Francisca; Vergara,Macarena; Toloza,Lorena; Gonzalez,Jaime; Morales,Erik; Palomo,Iván.
Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial. Entre ellas tienen gran relevancia las de tipo isquémicas, en donde el desarrollo de placas ateroscleróticas es el proceso fisiopatológico central. El estudio de la aterosclerosis es fundamental para comprender como se inicia este proceso patológico y los factores que influyen en su desarrollo. Distintas metodologías de laboratorio, entre otras la inmunohistoquímica, permiten reconocer las células y moléculas que participan en el proceso ateromatoso y que van interactuando según la progresión de la lesión. Un marcador de disfunción endotelial es la mayor expresión de la molécula de adhesión intercelular ICAM-1. En este trabajo se realizó la estandarización de...
Tipo: Journal article Palavras-chave: ICAM-1; Aterosclerosis; Inmunohistoquímica.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400047
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Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients Biol. Res.
Vicuña,Lucas; Pardo,Evelyn; Curkovic,Cristóbal; Doger,Remziye; Oyanadel,Claudia; Metz,Claudia; Massardo,Loreto; González,Alfonso; Soza,Andrea.
Galectin-8 belongs to a family of mammalian lectins that recognize glycoconjugates present on different cell surface components and modulate a variety of cellular processes. A role of Gal-8 in the immune system has been proposed based on its effects in immune cells, including T and B lymphocytes, as well as the presence of anti-Gal-8 autoantibodies in the prototypic autoimmune disease systemic lupus erythematosus (SLE). We have previously described that Gal-8 induces apoptosis in activated T cells interacting with certain β1 integrins and this effect is counteracted by the anti-Gal-8 autoantibodies. Given that Gal-8 can potentially interact with several glycoproteins, here we analyzed the β2 integrin Lymphocyte Function-Associated...
Tipo: Journal article Palavras-chave: Galectin-8; LFA-1; ICAM-1; SLE; Autoantibodies.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300008
Registros recuperados: 5
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