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Registros recuperados: 6
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Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures Inra
Rospars, J.P.; Lansky, P.; Chaput, M.; Duchamp-Viret, P..
Most olfactory receptor neurons (ORNs) express a single type of olfactory receptor that is differentially sensitive to a wide variety of odorant molecules. The diversity of possible odorant-receptor interactions raises challenging problems for the coding of complex mixtures of many odorants, which make up the vast majority of real world odors. Pure competition, the simplest kind of interaction, arises when two or more agonists can bind to the main receptor site, which triggers receptor activation, although only one can be bound at a time. Noncompetitive effects may result from various mechanisms, including agonist binding to another site, which modifies the receptor properties at the main binding site. Here, we investigated the electrophysiological...
Tipo: Journal Article Palavras-chave: CODAGE; MODELE; OLFACTION; NEURONE; RECEPTEUR; ODEUR; INTERACTION MOLECULAIRE; CONCENTRATION; ANALYSE STATISTIQUE  SENSORY CODING; OLFACTORY RECEPTOR NEURON; IN VIVO; SIGNAL TRANSDUCTION; ALLOSTERY; MIXTURE INTERACTION.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20105031bac0&uri=/notices/prodinra1/2010/10/
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Enterococcal Leucine-Rich Repeat-Containing Protein Involved in Virulence and Host Inflammatory Response Inra
Brinster, S.; Posteraro, B.; Bierne, H.; Alberti, A.; Makhzami, S.; Sanguinetti, M.; Serror, P..
Enterococcus faecalis is an important nosocomial pathogen associated with high morbidity and mortality for patients who are immunocompromised or who have severe underlying diseases. The E. faecalis genome encodes numerous surface-exposed proteins that may be involved in virulence. This work describes the characterization of the first internalin-like protein in E. faecalis, ElrA, belonging to the recently identified WxL family of surface proteins. ElrA contains an N-terminal signal peptide for export, a leucine-rich repeat domain that may interact with host cells, and a C-terminal WxL domain that interacts with the peptidoglycan. Disruption of the elrA gene significantly attenuates bacterial virulence in a mouse peritonitis model. The elrA deletion...
Tipo: Journal Article Palavras-chave: ENTEROCOCCUS FAECALIS; VIRULENCE BACTERIENNE; PROTEINE; AGENT PATHOGENE VIRULENT; POUVOIR PATHOGENE; INFLAMMATION; BACTERIE NOSOCOMIALE; EXPRESSION DES GENES; IN VIVO; LEUCINE.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200941085a57&uri=/notices/prodinra1/2009/07/
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Flavour perception: aroma, taste and texture interactions Inra
Tournier, C.; Sulmont-Rossé, C.; Guichard, E..
Flavour perception is determinant for the acceptability of food products by consumers. Aroma and taste play an important role in flavour perception and it is well known that the chemical composition of the matrix and consequently its structure influences release and perception of flavour. However, from simultaneous measurements of human perception and physical concentration in vivo, texture – aroma and texture – taste interactions are not always explained by physico-chemical mechanisms. Moreover aroma – taste interactions have been the subject of many studies already reviewed and are mainly explained by cognitive interactions even if in some case physicochemical mechanisms may occur. Finally, few studies mentioned the impact of aroma and taste on texture...
Tipo: Book Chapter Palavras-chave: FLAVEUR; AROME; PROPRIETE ORGANOLEPTIQUE; MECANISME COGNITIF; PRODUIT ALIMENTAIRE; IN VIVO; TEXTURE; SENS DU GOUT; PHYSIOLOGIE SENSORIELLE FLAVOUR PERCEPTION; FOOD PRODUCTS; AROMA; TASTE; TEXTURE; INTERACTIONS; COGNITIVE MECHANISMS; CROSS-MODAL INTERACTIONS; PHYSICO-CHEMISTRY.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2008fd8f4c38&uri=/notices/prodinra1/2009/03/
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Identification of plant partners of polerovirus structural proteins Inra
Boissinot, S.; Revollon, S.; Erdinger, M.; Bencharki, B.; Ziegler-Graff, V.; Brault, V..
Tipo: Conference Proceedings Palavras-chave: POLEROVIRUS; PROTEINS; RNA GENOME; IN VITRO; IN VIVO.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201054a3c3d1&uri=/notices/prodinra1/2011/01/
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In vitro and in vivo assessement of the antimalarial activity of sergeolide IRD
Fandeur, T.; Moretti, Christian; Polonsky, J..
L'activité antiplasmodiale, in vitro, in vivo du Sergeolide, Quassinoide isolé de #Picrolemma pseudocoffea$ a été mesurée, in vitro, sur des cultures de #Plasmodium faliciparum$ et in vivo par le test classique de la mesure de l'activité schizonticide sur le paludisme du rongeur, à #Plasmodium berghei$. Le sergeolide manifeste une forte activité antiplasmodiale, aussi bien in vitro que in vivo, à des doses extrêmement faibles. Une concentration de 0,006 microg/ml inhibe complètement la croissance des cultures de diverses souches de #Plasmodium faliciparum$, sensibles et résistantes à la choroquine. Une dose de 0,26 mg/kg/j réduit considérablement la virulence du paludisme à #Plasmodium berghei$ chez la souris. Cependant, la forte toxicité du sergeolide...
Tipo: Text Palavras-chave: SUBSTANCE NATURELLE; TOXICITE; PALUDISME; TRAITEMENT MEDICAL; PARASITE; QUASSINOIDE; SERGEOLIDE; PRINCIPE ACTIF; IN VITRO; IN VIVO.
Ano: 1985 URL: http://www.documentation.ird.fr/hor/fdi:26819
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In vivo anti-tumour activity of ethyl heptyloxyacetate against Ehrlich ascites cells National Institute of Agronomic Research
Townsend, Gordon F.; Brown, William H.; Felauer, Ethel E..
PREVIOUS investigations have shown that whole royal jelly, a fraction from royal jelly (10-hydroxy-2-decenoic acid) and certain closely related dicarboxylic acids, some of which are also found in royal jelly, will inhibit the development of transplantable AKR leukæmia and ascites tumours when added in vitro just prior to transfer. This activity was associated mainly with 9-and 10-carbon straight-chain monocarboxylic acids, particularly decanoic acid in the ethyl ester form. These compounds showed no activity in vivo.
Tipo: Journal Article-postprint Palavras-chave: ROYAL JELLY; HIVE PRODUCT; HEPTYLOXYACETATE; ANTI¬TUMOR; AKR LEUKAEMIA; ASCITE CELL; IN VIVO; MOUSE; GELEE ROYALE; PRODUIT DU RUCHER; HEPTYLOXYACETATE; ANTI-TUMEUR; LEUCEMIE; AKR; IN VIVO; SOURIS.
Ano: 1963 URL: http://hdl.handle.net/2174/437
Registros recuperados: 6
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