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Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models Anais da ABC (AABC)
SOUSA-NETO,BENEDITO P.; GOMES,BRUNO S.; CUNHA,FRANCISCO V.M.; ARCANJO,DANIEL D.R.; GUTIERREZ,STANLEY J.C.; SOUZA,MARIA F.V.; ALMEIDA,FERNANDA R.C.; OLIVEIRA,FRANCISCO A..
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anti-inflammatory agents; Edema; Indoles; Inflammation mediators; N-salicyloyltryptamine.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100185
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Synthesis of β - benzo[b]thienyldehydrophenylalanine derivatives by one-pot palladium-catalyzed borylation and suzuki coupling (BSC) and metal-assisted intramolecular cyclization: studies of fluorescence and antimicrobial activity IPB - Escola Superior Agrária
Abreu, Ana S.; Ferreira, Paula M.T.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Estevinho, Leticia M..
Palladium-catalyzed borylation and Suzuki coupling (BSC) in a one-pot procedure was successfully applied to the synthesis of several β-substituted dehydrophenylalanines in the benzo[b]thiophene series, with the stereochemistry of the starting materials being maintained. Bromobenzo[b]thiophenes bearing an ortho EDG (OMe or Me) were used as the components to be borylated with pinacolborane, whilst pure stereoisomers of β-bromodehydrophenylalanines were used as the other Suzuki coupling components. Treatment of the obtained methyl ester of (Z)-N-(tert-butoxycarbonyl)-β- (2,3,5-trimethylbenzo[b]thien-6-yl)dehydrophenylalanine with Pd(OAc)2 and Cu(OAc)2 in DMF at 160 °C gave two in dole derivatives (1:3), the major product resulting from isomerization and...
Tipo: Article Palavras-chave: Dehydrophenylalanines; Benzothiophenes; Borylation; Suzuki coupling; Cyclization; Indoles; Fluorescence; Antimicrobial activity.
Ano: 2005 URL: http://hdl.handle.net/10198/823
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