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Registros recuperados: 8
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Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate International Journal of Morphology
Bomfim,Kátia Michelle dos Anjos; Garcia,Carlos Alexandre Borges; Reis,Francisco Prado; Palmeira,José Arnaldo Vasconcelos; Scher,Ricardo; de Lucca Júnior,Waldecy; Aragão,José Adeval; Vasconcelos,Francis Lima; Albuquerque Júnior,Ricardo Luiz Cavalcanti; Feitosa,Vera Lúcia Corrêa.
Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from...
Tipo: Journal article Palavras-chave: Lead acetate; Fetuses; Lung; Kidney.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100021
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Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependent BJMBR
Silveira,E.A.; Lizardo,J.H.F.; Souza,L.P.; Stefanon,I.; Vassallo,D.V..
Chronic lead exposure induces hypertension in humans and animals, affecting endothelial function. However, studies concerning acute cardiovascular effects are lacking. We investigated the effects of acute administration of a high concentration of lead acetate (100 µΜ) on the pressor response to phenylephrine (PHE) in the tail vascular bed of male Wistar rats. Animals were anesthetized with sodium pentobarbital and heparinized. The tail artery was dissected and cannulated for drug infusion and mean perfusion pressure measurements. Endothelium and vascular smooth muscle relaxation were tested with acetylcholine (5 µg/100 µL) and sodium nitroprusside (0.1 µg/100 µL), respectively, in arteries precontracted with 0.1 µM PHE. Concentration-response curves to PHE...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lead acetate; Vascular reactivity; Endothelium; Hypertension.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500011
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Alterações fi siológicas e ultraestruturais de plântulas de tomate induzidas por chumbo. Repositório Alice
MORAES, C. L.; MARINI, P.; FERNANDO, J. A.; MORAES, D. M. de.; CASTRO, L. A. S. de; LOPES, N. F..
2014
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Chloroplast; Growth; Lead acetate; Lycopersicon esculentum.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1012135
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Antidepressant-like effect of lead in adult mice BJMBR
Mantovani,M.; Matteussi,A.S.; Rodrigues,A.L.S..
It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Forced swimming test; Depression; Open-field.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200017
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Effects of lead and/or zinc exposure during the second stage of rapid postnatal brain growth on delta-aminolevulinate dehydratase and negative geotaxis of suckling rats BJMBR
Goulart,E.C.; Pereira,C.A.T.; Garcia,R.C.; Giacomelli,M.B.O.; Rodrigues,A.L.S..
Lead has been shown to produce cognitive and motor deficits in young rats that could be mediated, at least in part, by inhibition of the zinc-containing heme biosynthetic enzyme delta-aminolevulinate dehydratase (ALA-D). In the present study we investigated the effects of lead and/or zinc treatment during the second stage of rapid postnatal brain development on brain, kidney and blood ALA-D specific activity, as well as the negative geotaxis behavior of rats. Eight-day-old Wistar rats were injected intraperitoneally with saline, lead acetate (8 mg/kg) and/or zinc chloride (2 mg/kg) daily for five consecutive days. Twenty-four hours after treatment, ALA-D activity was determined in the absence and presence of DL-dithiothreitol (DTT). The negative geotaxis...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Zinc chloride; Delta-aminolevulinate dehydratase; Negative geotaxis; Postnatal brain growth.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600014
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Effects of sub-lethal exposure of lead acetate on histopathology of gills, liver, kidney and muscle and its accumulation in these organs of Clarias gariepinus BABT
Al-Balawi,Hmoud Fares Alkahem; Al-Akel,Ali Sulaiman; Al-Misned,Fahad; Suliman,El Amin Mohamed; Al-Ghanim,Khalid Abdullah; Mahboob,Shahid; Ahmad,Zubair.
The aim of this work was to study the effects of sub-lethal exposure of lead acetate on the histopathology of the gills, liver, kidney and muscle and its accumulation in these organs of Clarias gariepinus. Results showed that lead accumulation in the tissues of C. gariepinus was dependent on the exposure period and lead concentration. Gills and liver were the predominant storage tissue and the order of accumulation in tissues was gill > liver > kidney > muscle. Some structural changes were observed in different organs, especially in the gills of the fishes exposed to lead acetate. Epithelial hypertrophy and epithelial lifting were apparent in the gills of exposed fishes. The degeneration of cytoplasm and secondary lamellae was also observed....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clarias gariepinus; Lead acetate; Accumulation; Histopathology.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200015
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Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate International Journal of Morphology
Sula,Bilal; Deveci,Engin; Özevren,Hüseyin; Ekinci,Cenap; Elbey,Bilal.
Lead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were...
Tipo: Journal article Palavras-chave: Lead acetate; Skin; Proliferating cell nuclear antigen; Vimentin.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300017
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Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate International Journal of Morphology
Deveci,E; Söker,S; Baran,Ö; Tunik,S; Ayaz,E; Deveci,S.
The purpose of this study was to investigate the ultrastructural effects of lead on the kidney cortex of rats. Wistar Albino rats (180-200g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were taken from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. The kidney tissue samples were prepared and analyzed by light and transmission electron microscopy. Cortical renal tubules show various degenerative changes with focal tubular necrosis...
Tipo: Journal article Palavras-chave: Lead acetate; Kidney cortex; Ultrastructural changes.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300067
Registros recuperados: 8
Primeira ... 1 ... Última
 

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