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Neoangiogenesis Induced by Progenitor Endothelial Cells: Effect of Fucoidan from Marine Algae ArchiMer
Boisson-vidal, C; Zemani, F; Calliguiri, G; Galy-fauroux, I; Colliec-jouault, Sylvia; Helley, D; Fischer, A-m.
Fucoidans -- sulphated polysaccharides extracted from brown algae - could be beneficial in patients with ischemic diseases. Their antithrombotic and proangiogenic properties promote in animals, neovascularization and angiogenesis which prevent necrosis of ischemic tissue. In 1997, endothelial progenitor cells were first identified in human peripheral blood. They are recruited from bone marrow and contribute to neovascularization after ischemic injury. Mobilization of these cells in ischemic sites is an important step in new vessel formation. It is thought that the progenitors interact with endothelial cells, then extravasate and reach ischemic sites, where they proliferate and differentiate into new blood vessels. Although chemokines, cytokines and...
Tipo: Text Palavras-chave: Growth factors; Cytokines; Angiogenesis; Neovascularization; Endothelial progenitor cells; Sulphated polysaccharides; Fucoidan.
Ano: 2007 URL: http://archimer.ifremer.fr/doc/2007/publication-2168.pdf
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The effects of the subconjunctival injection of bevacizumab (Avastin®) on angiogenesis in the rat cornea Anais da ABC (AABC)
Barros,Luiz F.M.; Belfort-Jr,Rubens.
The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of bevacizumab (Avastin®) on angiogenesis in the rat cornea. Corneas of 20 Wistar male rats were cauterized with silver nitrate crystal. Animals were divided in four groups: control group (GC) that received subconjunctivally 0.02 ml of 0.9% saline solution on the day of the lesion; group GO that received subconjunctivally 0.02 ml of bevacizumab just after the lesion; group G3 that received bevacizumab on day 3 and group G5 that received bevacizumab on day 5 after lesion. Animals were euthanized on day 7. The newly formed vessels were quantified after China Ink perfusion and photographs were obtained and analyzed in a computerized system (Image Pro-Plus®). In...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bevacizumab; Cornea; Neovascularization; Angiogenesis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000300004
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