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| Gradinaru, D.; Minn, A.L.; Artur, Y.; Minn, A.; Heydel, J.M.. |
| The presence of drug metabolizing enzymes in extrahepatic tissues such as the choroid plexus (CP) suggests that the CP, like the blood–brain barrier, affords a metabolic protection to the brain against xenobiotics. The CP, which is the principal site of formation of the cerebrospinal fluid (CSF), controls the exchange of many endogenous compounds and exogenous molecules between brain tissue and CSF. We present the changes in mRNA expression and enzymatic activities of UDP-glucuronosyltransferase, UGT1A6 isoform and NADPH-cytochrome P450 reductase, after in vitro treatment with xenobiotic molecules known to act in the liver as inducers or inhibitors of these drug metabolizing enzymes. Five study groups of male Sprague–Dawley rats were treated separately... |
| Tipo: Journal Article |
Palavras-chave: CHOROID PLEXUS; DRUG METABOLIZING ENZYMES; GLUCURONIDATION; PARAQUAT. |
| Ano: 2009 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20097e1f138a&uri=/notices/prodinra1/2010/10/ |
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