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Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars International Journal of Morphology
Oliveira,David Moraes de; Silveira,Márcia Maria Ferreira da; Andrade,Emanuel Sávio de Souza; Sobral,Ana Paula Veras; Martins-Filho,Paulo Ricardo Saquete; Santos,Thiago de Santana; Oliveira,Patrícia Leimig Amorim de; Peixoto,Aline Carvalho; Santos,Jadson Alípio Santana de Souza; Piva,Marta Rabello.
This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic...
Tipo: Journal article Palavras-chave: Immunohistochemistry; Dental follicle; Odontogenic epithelial; PTCH.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018
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No evidence for mutations in exons 1, 8 and 18 of the patched gene in sporadic skin lesions of Brazilian patients BJMBR
Granja,F.; Santarosa,P.L.; Leite,J.L.A.A.P.; Ward,L.S..
There is strong evidence that the patched (PTCH) gene is a gene for susceptibility to the nevoid basal cell carcinoma syndrome. PTCH has also been shown to mutate in both familial and sporadic basal cell carcinomas. However, mutations of the gene seem to be rare in squamous cell carcinomas. In order to characterize the role of the gene in the broader spectrum of sporadic skin malignant and pre-malignant lesions, we performed a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis of genomic DNA extracted from 105 adult patients (46 females and 59 males). There were 66 patients with basal cell carcinomas, 30 with squamous cell carcinomas, 2 with malignant melanomas and 7 patients with precancerous lesions. Two tissue samples...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Skin; Cancer; PTCH; Mutation.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400006
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