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An acid-sensing ion channel that detects ischemic pain BJMBR
Naves,L.A.; McCleskey,E.W..
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory neurons that innervate muscle. One such compound is lactic acid. Here, we show that ASIC3 (acid-sensing ion channel #3) has the appropriate expression pattern and physical properties to be the detector of this lactic acid. In rats, it is expressed only in sensory neurons and then only on a minority (~40%) of these. Nevertheless, it is expressed at extremely high levels on virtually all dorsal root ganglion sensory neurons that innervate the heart. It is extraordinarily sensitive to protons (Hill slope 4,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pain; Ischemia; Dorsal root ganglia; Acid-sensing ion channels; Lactic acidosis.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100001
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An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice BJMBR
Magro,D.A.C.; Hohmann,M.S.N.; Mizokami,S.S.; Cunha,T.M.; Alves-Filho,J.C.; Casagrande,R.; Ferreira,S.H.; Liew,F.Y.; Cunha,F.Q.; Verri Jr,W.A..
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Interleukin-33; ST2; Pain; Nociception; Inflammation.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000700601
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Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (eugenol) by the formalin test: an anti-inflammatory effect BJPS
Lugo-Lugo,Daniela Elizabeth; Pozos-Guillén,Amaury de Jesús; Zapata-Morales,Juan Ramón; Rodríguez-Chong,Antonio; Rangel-López,Azahel de Jesús; Saavedra-Leos,María Zenaida; Vértiz-Hernández,Angel Antonio.
Eugenol has been employed for decades as a condiment, an antimycotic, an antibacterial, an antiviral, and an antioxidant, and it is one of the natural analgesics most frequently utilized for pain and inflammation. Our objective was to determine the analgesic/anti-inflammatory effect of eugenol compared with diclofenac, naproxen, and tramadol using the formalin test. The formalin method was used in 6- to 10-week-old Wistar rats (weighing 250 g each) divided into six groups: saline (0.9%); formalin (5%); diclofenac (250 µg/kg); naproxen (400 µg/kg); tramadol (500 µg/kg), and eugenol (1,400 µg/kg), in the intraplantar part of the hind-end trunk of the rats, with n = 5 per group. Eugenol diminished 44.4% of nociceptive behavior in phase 1 and 48% in phase 2 (p...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Eugenol/analgesic/anti-inflammatory effect; Diclofenac effect; Antinociception; Formalin test; Pain.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100536
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Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats BJMBR
Prado,W.A.; Machado Filho,E.B..
A close relationship exists between calcium concentration in the central nervous system and nociceptive processing. Aminoglycoside antibiotics and magnesium interact with N- and P/Q-type voltage-operated calcium channels. In the present study we compare the antinociceptive potency of intrathecal administration of aminoglycoside antibiotics and magnesium chloride in the tail-flick test and on incisional pain in rats, taken as models of phasic and persistent post-surgical pain, respectively. The order of potency in the tail-flick test was gentamicin (ED50 = 3.34 µg; confidence limits 2.65 and 4.2) > streptomycin (5.68 µg; 3.76 and 8.57) = neomycin (9.22 µg; 6.98 and 12.17) > magnesium (19.49 µg; 11.46 and 33.13). The order of potency to reduce...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gentamicin; Neomycin; Streptomycin; Magnesium; Antinociception; Aminoglycosides; Pain.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300017
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Antinociceptive properties of the mastoparan peptide Agelaia-MPI isolated from social wasps. Repositório Alice
GONÇALVES, J.; RANGEL, M.; BIOLCHI, A.; ALVES, E.; MOREIRA, K.; SILVA, L.; MORTARI, M..
bitstream/item/180096/1/1-s2.0-S0041010116302112-main.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Mastoparan; Agelaia-MP I; Antinociception; Pain; Sodium channels.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1055090
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Central release of nitric oxide mediates antinociception induced by aerobic exercise BJMBR
Galdino,G.S.; Duarte,I.D.; Perez,A.C..
Nitric oxide (NO) is a soluble gas that participates in important functions of the central nervous system, such as cognitive function, maintenance of synaptic plasticity for the control of sleep, appetite, body temperature, neurosecretion, and antinociception. Furthermore, during exercise large amounts of NO are released that contribute to maintaining body homeostasis. Besides NO production, physical exercise has been shown to induce antinociception. Thus, the present study aimed to investigate the central involvement of NO in exercise-induced antinociception. In both mechanical and thermal nociceptive tests, central [intrathecal (it) and intracerebroventricular (icv)] pretreatment with inhibitors of the NO/cGMP/KATP pathway (L-NOArg, ODQ, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Exercise; Pain; Antinociception.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900790
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Effect of repeated stress on novelty-induced antinociception in rats BJMBR
Torres,I.L.S.; Vasconcellos,A.P.; Silveira Cucco,S.N.; Dalmaz,C..
There is extensive evidence that acute stress induces an analgesic response in rats. On the other hand, repeatedly stressed animals may present the opposite effect, i.e., hyperalgesia. Furthermore, exposure to novelty is known to induce antinociception. The effects of repeated restraint stress on nociception after exposure to novelty, as measured by the tail-flick latency (TFL), were studied in adult male rats. The animals were stressed by restraint 1 h daily, 5 days a week for 40 days. The control group was not submitted to restraint. Nociception was assessed with a tail-flick apparatus. After being familiarized with the TFL apparatus, each group was subdivided into two other groups, i.e., with or without novelty. Animals were subjected to the TFL...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Pain; Stress; Repeated stress; Nociception; Novelty.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200012
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Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis BJMBR
Rodrigues,T.A.; Sampaio Junior,A.J.B.; Nunes,I.D.P.; Cartágenes,M.S.S.; Garcia,J.B.S..
Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Osteoarthritis; Strontium ranelate; Pain; Treatment; Prophylaxis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900602
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Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery BJMBR
Barroso,A.B.; Lima,V.; Guzzo,G.C.; Moraes,R.A.; Vasconcellos,M.C.; Bezerra,M.M.; Viana,F.A.L.; Bezerra,R.C.R.; Santana,G.S.M.; Frota-Bezerra,F.A.; Moraes,M.O.; Moraes,M.E.A..
Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin®) when compared with 20 mg piroxicam alone (Feldene®) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They received (vo) Rheumazin or Feldene 30 min after tooth extraction and once daily for 4 consecutive days. Pain was determined by a visual analogue scale and by the need...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Piroxicam; Dexamethasone; Orphenadrine; Cyanocobalamin; Pain; Mandibular molar surgery.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900012
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Exposure to electric field (EF) : Its palliative effect on some clinical symptoms in human patients OAK
Harakawa, Shinji; Doge, Fuyuki; Saito, Atsushi; 原川, 信二; 道解, 冬樹; 齋藤, 篤志.
Palavras-chave: Commercial power frequency; Extremely low frequency; Electric field; Pain; 商用周波数; 超低周波数; 電界; 疼痛.
Ano: 2002 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/116
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Expression of Fos protein in the rat central nervous system in response to noxious stimulation: effects of chronic inflammation of the superior cervical ganglion BJMBR
Laudanna,A.; Nogueira,M.I.; Mariano,M..
The aim of this study was to investigate the possible interactions between the nociceptive system, the sympathetic system and the inflammatory process. Thus, the superior cervical ganglion of rats was submitted to chronic inflammation and Fos expression was used as a marker for neuronal activity throughout central neurons following painful peripheral stimulation. The painful stimulus consisted of subcutaneously injected formalin applied to the supra-ocular region. Fos-positive neurons were identified by conventional immunohistochemical techniques, and analyzed from the obex through the cervical levels of the spinal cord. In the caudal sub-nucleus of the spinal trigeminal nuclear complex, the number of Fos-positive neurons was much higher in rats with...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Autonomic nervous system; Pain; Sympathetic system; Trigeminal complex.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600019
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Fish welfare: the state of science by scientometrical analysis Biological Sciences
Ghisi, Nédia de Castilhos; Oliveira, Elton Celton de.
 In 2014, Brazil produced 474.33 thousand tons of captive-bred fish. In addition, regulatory agencies of animal ethics and welfare have recently encouraged experiments to be done using simpler vertebrates, such as fish. The aim of this article was to perform a scientometric analysis of scientific production that deals with fish welfare, in an attempt to find trends and gaps in this line of research. Our analyses showed a growing concern about fish welfare, although several questions remained inadequately covered. The most studied species was the Atlantic salmon, with Norway having the most publications on this theme. There are controversies among scientists about fish capacity for suffering and enjoyment (sentience). As regards slaughter or euthanasia,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.04.06.02-9 suffering; Pain; Euthanasia; Stress; Humane slaughter Utilização dos Animais.
Ano: 2016 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31785
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Infrared coagulation versus rubber band ligation in early stage hemorrhoids BJMBR
Gupta,P.J..
The ideal therapy for early stages of hemorrhoids is always debated. Some are more effective but are more painful, others are less painful but their efficacy is also lower. Thus, comfort or efficacy is a major concern. In the present randomized study, a comparison is made between infrared coagulation and rubber band ligation in terms of effectiveness and discomfort. One hundred patients with second degree bleeding piles were randomized prospectively to either rubber band ligation (N = 54) or infrared coagulation (N = 46). Parameters measured included postoperative discomfort and pain, time to return to work, relief in incidence of bleeding, and recurrence rate. The mean age was 38 years (range 19-68 years). The mean duration of disease was 17.5 months...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemorrhoids; Infrared coagulation; Pain; Rubber band ligation; Piles.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000022
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Local dermal application of a compound lidocaine cream in pain management of cancer wounds BJMBR
Peng,L.; Zheng,H.Y.; Dai,Y..
The aim of this study was to explore the analgesic effect of local application of compound lidocaine/prilocaine cream on cancer wounds during wound care in order to reduce the amount of morphine intake or completely replace the systemic morphine administration and optimize the protocol for cancer wound pain management. All patients were enrolled with a visual analog scale (VAS) pain score ≥4. Before wound care, 60 patients were randomly divided into 2 groups of 30 each: morphine group (10 mg tablet); topical 5% compound lidocaine cream group (0.2 g/cm2). VAS scores, heart rate, and Kolcaba comfort level were recorded for the two groups 10 min before and 10, 15, 20, and 25 min after wound care and data were analyzed statistically. The means for the pain...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Local; Compound lidocaine cream; Cancer wound; Pain.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100609
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Neuropharmacological effects of essential oil from the leaves of Croton conduplicatus Kunth and possible mechanisms of action involved. Repositório Alice
OLIVEIRA JÚNIOR, R. G. de; FERRAZ, C. A. A.; SILVA, J. C.; TELES. R. B. de A.; SILVA, M. G.; DINIZ, T. C.; SANTOS, U. S. dos; SOUZA, A. V. de; NUNES, C. E. P.; SALVADOR, M. J.; LORENZO, V. P.; QUINTANS JÚNIOR, L. J.; ALMEIDA, J. R. G. da S..
Ethnopharmacological relevance: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as ?quebra-faca?. In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches. Aim of the study: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia. The mechanisms of action involved in these activities were also investigated.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Ansiedade; Dor; Insônia; Bioma Caatinga; Planta nativa; Quebra faca; Essential oil; Insomnia; Óleo essencial; Planta medicinal; Recurso natural; Anxiety; Pain; Medicinal plants.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1090904
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Pain and distress outcomes in infants and children: a systematic review BJMBR
Oliveira,N.C.A.C.; Gaspardo,C.M.; Linhares,M.B.M..
The aim of the present study was to systematically review the recent literature about pain and distress outcomes in children and critically analyze the methodological quality of the reports. The systematic review was based on the PRISMA statement and performed by selecting articles that are indexed in scientific databases. The methodological quality of reports was examined using STROBE statement, for observational studies, and CONSORT statement, for randomized controlled trials. The PedIMMPACT consensus was used to evaluate the psychometric quality of pain instruments. We analyzed 23 empirical studies, including 14 randomized controlled trials, seven cross-sectional studies, and two studies with cohort designs. Fourteen studies included preschool- and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Children; Development; Distress; Pain; Review.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700302
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Pain in hospitalized HIV-positive patients: clinical and therapeutical issues BJID
Aires,Elisa Miranda; Bammann,Ricardo H..
Pain is frequently reported by patients infected with Acquired Immunodeficiency Virus (HIV), and its causes and specific treatment should be appropriately investigated. We evaluated 197 hospitalized HIV-positive patients with serial interviews and analysis of prescriptions and clinical evolution charts. The main characteristics of pain reported by these patients were: high intensity (60.7%), high frequency (72.0%) and well-known causes (88.8%). Fifty-two per cent of the patients reported persistent or frequent pain during the two weeks before hospital admission. Parameters such as gender, educational level and Karnofsky Index showed no direct relation to the presence or absence of pain. The most commonly affected sites were the head (28.0%) and the abdomen...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pain; HIV; AIDS; Analgesic treatment; Undertreatment; Pain management index.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300002
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Pain prevalence, characteristics and associated factors in human T-cell lymphotropic virus type 1 infected patients: a systematic review of the literature BJID
San-Martin,Daniel Lordelo; Santos,Dislene Nascimento dos; Baptista,Abrahão Fontes.
ABSTRACT Objective: To describe the pain in patients infected with human T-cell lymphotropic virus type 1, clinically and epidemiologically. Methods: This systematic review was based on The PRISMA Statement. Four reviewers searched PUBMED, SciELO, LILACS and BIREME for data from observational studies and clinical trials (n ≥ 30) regarding pain prevalence, characteristics, and associated factors in patients with human T-cell lymphotropic virus type 1. No limits on publication date or language were established. Studies that did not have pain as an outcome measure or not involving human T-cell lymphotropic virus type 1 infected patients were excluded. Results: A total of 3013 articles (including duplicates) were found of which seven met the predetermined...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-1; HAM/TSP; Pain; Prevalence.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600592
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Pediatric pain: prevalence, assessment, and management in a teaching hospital BJMBR
Linhares,M.B.M.; Doca,F.N.P.; Martinez,F.E.; Carlotti,A.P.P.; Cassiano,R.G.M.; Pfeifer,L.I.; Funayama,C.A.; Rossi,L.R.G.; Finley,G.A..
The goal of this study was to examine the prevalence, assessment and management of pediatric pain in a public teaching hospital. The study sample consisted of 121 inpatients (70 infants, 36 children, and 15 adolescents), their families, 40 physicians, and 43 nurses. All participants were interviewed except infants and children who could not communicate due to their clinical status. The interview included open-ended questions concerning the inpatients’ pain symptoms during the 24 h preceding data collection, as well as pain assessment and pharmacological/non-pharmacological management of pain. The data were obtained from 100% of the eligible inpatients. Thirty-four children/adolescents (28%) answered the questionnaire and for the other 72% (unable to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pain; Inpatients; Policy; Clinical audit.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200026
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Perspectives in veterinary medicine on the use of cannabinoids as complementary palliative therapy for pain in cancer patients Ciência Rural
Repetti,Cláudia Sampaio Fonseca; Girio,Raul José Silva; Friolani,Milena; Barbalho,Sandra Maria.
ABSTRACT: Pain in the cancer patient is an important clinical manifestation that results in low life expectancy and poor prognosis. Pain may be related to tumor type, invasion of adjacent tissues, metastasis, and diagnostic and therapeutic procedures with variable response to analgesic therapy. Many studies have called attention due to their potential therapeutic effect in the modulation of pain and inflammation. Cannabinoid derivatives are chemical compounds obtained from Cannabis that act on specific receptors.Several commercial products have already been approved in Europe and the USA for use in human patients. The present study aimed to review articles on the use of cannabinoids in the control of pain contributing to the well-being and quality of life...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pain; Cannabinoids; Cannabidiol; Oncology..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000200600
Registros recuperados: 30
Primeira ... 12 ... Última
 

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