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A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems J. Venom. Anim. Toxins incl. Trop. Dis.
Pacheco,Daniela da Fonseca; Freitas,Ana Cristina Nogueira; Pimenta,Adriano Monteiro C.; Duarte,Igor Dimitri Gama; Lima,Maria Elena de.
Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in its action mechanism. Methods Nociceptive threshold to thermal stimulation was measured according to the tail-flick test in Swiss mice. All drugs were administered by the intracerebroventricular route. Results PnPP-19 induced central antinociception in mice in the doses of 0.5 and 1 μg. The non-selective opioid receptor antagonist naloxone (2.5 and 5 μg), μ-opioid receptor antagonist clocinnamox (2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Peptide PnPP-19; Central antinociception; Phoneutria nigriventer; Μ-opioid receptor; Δ-opioid receptor; CB1 receptor; CB2 receptor.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100325
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An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches. Repositório Alice
DINIZ, M. R. V.; PAIVA, A. L. B.; GUERRA-DUARTE, C.; NISHIYAMA JÚNIOR, M. Y.; MUDADU, M. de A.; OLIVEIRA, U. de; BORGES, M. H.; YATES, J. R.; JUNQUEIRA-DE-AZEVEDO, I. de.
Abstract. Phoneutria nigriventer is one of the largest existing true spiders and one of the few considered medically relevant. Its venom contains several neurotoxic peptides that act on different ion channels and chemical receptors of vertebrates and invertebrates. Some of these venom toxins have been shown as promising models for pharmaceutical or biotechnological use. However, the large diversity and the predominance of low molecular weight toxins in this venom have hampered the identification and deep investigation of the less abundant toxins and the proteins with high molecular weight. Here, we combined conventional and next-generation cDNA sequencing with Multidimensional Protein Identification Technology (MudPIT), to obtain an in-depth panorama of...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Proteômica; Transcriptoma; Phoneutria nigriventer; Proteomics; Transcriptomics.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1102272
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Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system J. Venom. Anim. Toxins incl. Trop. Dis.
Oliveira,Camila Franco Batista; Alves,Daniela Pereira; Emerich,Bruna Luiza; Figueiredo,Suely Gomes de; Cordeiro,Marta do Nascimento; Borges,Márcia Helena; Richardson,Michael; Pimenta,Adriano Monteiro de Castro; Duarte,Igor Dimitri Gama; Lima,Maria Elena de.
ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it inhibited NMDA-evoked currents in rat hippocampal neurons. In this work the analgesic activity of PnTx4(5-5) (renamed Γ-ctenitoxin-Pn1a) was investigated. Methods: The antinociceptive activity was evaluated using the paw pressure test in rats, after hyperalgesia induction with intraplantar injection of carrageenan or prostaglandin E2 (PGE2). Results: PnTx4(5-5), subcutaneously injected, was able to reduce the hyperalgesia induced by PGE2 in rat paw, demonstrating a systemic effect. PnTx4(5-5)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spider toxin; Γ-ctenitoxin-Pn1a; PnTx4(5-5); Phoneutria nigriventer; Antinociception; Glutamate.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100316
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Binding sites and actions of Tx1, a neurotoxin from the venom of the spider Phoneutria nigriventer, in guinea pig ileum BJMBR
Santos,R.G.; Diniz,C.R.; Cordeiro,M.N.; De Lima,M.E..
Tx1, a neurotoxin isolated from the venom of the South American spider Phoneutria nigriventer, produces tail elevation, behavioral excitation and spastic paralysis of the hind limbs after intracerebroventricular injection in mice. Since Tx1 contracts isolated guinea pig ileum, we have investigated the effect of this toxin on acetylcholine release, as well as its binding to myenteric plexus-longitudinal muscle membranes from the guinea pig ileum. [125I]-Tx1 binds specifically and with high affinity (Kd = 0.36 ± 0.02 nM) to a single, non-interacting (nH = 1.1), low capacity (Bmax 1.1 pmol/mg protein) binding site. In competition experiments using several compounds (including ion channel ligands), only PhTx2 and PhTx3 competed with [125I]-Tx1 for specific...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Phoneutria nigriventer; Spider toxins; Binding; Enteric nervous system; Calcium channels; Guinea pig ileum.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200019
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Biodistribution studies of bee venom and spider toxin using radiotracers J. Venom. Anim. Toxins incl. Trop. Dis.
Yonamine,C. M.; Costa,H.; Silva,J. A. A.; Muramoto,E.; Rogero,J. R.; Troncone,L. R. P.; Camillo,M. A. P..
The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phoneutria nigriventer; Apis mellifera; Toxin; Venom; Radiotracer; Biodistribution.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100006
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Expressão da neurotoxina TX4-(6-1) em sistema heterólogo e bioensaio com a lagarta-do-cartucho (Spodoptera frugiperda). Repositório Alice
FIGUEIREDO, J. E. F.; ROCHA, T.L.; FONTES, M.A.; CRUZ, I.; KALAPOTHAKIS, E.; GOMEZ, M.V.; PURCINO, A. A. C..
2000
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Praga; Inseto; Lagarta do cartucho; Neurotoxina; Proteina; Fusao; Anticorpos; Controle biologico; Phoneutria nigriventer; Spodoptera frugiperda; Pest; Insecta; Antibody; Biological control; Protein; Fusion.
Ano: 2000 URL: http://www.alice.cnptia.embrapa.br/handle/doc/483854
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SPIDER ENVENOMING OF DOG - CASE REPORT J. Venom. Anim. Toxins
FERNANDES,H. S.; SAKATE,M.; CHERUBINI,A. L.; PADOVANI,A. F.; MENESES,A. M. C..
This report refers to a female Pinscher treated at the Veterinary Hospital of the Botucatu School of Veterinary Medicine and Animal Husbandry (FMVZ)-São Paulo State University (UNESP), Botucatu, 14 hours after a suspected spider envenoming. The animal showed spastic limbs, dyspnea, salivation, hypothermia, muscular fasciculation, non-responsive mydriasis, and claudication of the right hindlimb. The spider was later identified by the Center for the Study of Venoms and Venomous Animals-CEVAP/UNESP, Botucatu as Phoneutria nigriventer. The treatment with potent analgesic was efficient.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Spider envenoming; Phoneutria nigriventer; Dog.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100014
Registros recuperados: 7
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