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A model for the study of skeletal anomalies in rat fetuses BABT
Effting,Cristiane; Paula,Daniel Jesus de; Nunes Junior,Guilhermino Pereira.
The aim of this study was to validate a model of skeletal anomalies in rat fetuses by the administration of ketoconazole (80 mg/kg) to pregnant rats during organogenesis. Bones of the head, trunk and anterior and posterior limbs were examined for detection of anomalies. Statistical differences regarding the number of fetuses and postimplantation resorptions, and fetal and placental weight were significant. The frequency of skeletal anomalies in the head, trunk, and anterior and posterior limbs in the ketoconazole-treated group were also significant when compared to the control group. It could be concluded that the model suggested was valid for study of skeletal anomalies and abnormal bones development in rat fetuse, in spite of the loss of fetuses due to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Azol Antifungals; Ketoconazole; Models; Pregnancy; Skeletal Malformation; Steroids; Teratogenesis; Wistar Rats.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005
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Antiretroviral agents and acid-base balance at delivery of the neonate BJMBR
El-Beitune,P.; Duarte,G.; Morais,E.N. de; Campbell,O.; Spara-Gadelha,P.; Mauad-Filho,F.; Quintana,S.M.; Rodrigues,L.C..
Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with a = 0.05 and ß = 20%,...
Tipo: Info:eu-repo/semantics/other Palavras-chave: HIV; Infant toxicity; Pregnancy; Umbilical arterial pH; Apgar scores.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700010
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Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study BJMBR
Peres,R.M.; Sanseverino,M.T.V.; Guimarães,J.L.M.; Coser,V.; Giuliani,L.; Moreira,R.K.; Ornsten,T.; Schüler-Faccini,L..
The objective of the present study was to evaluate and quantify fetal risks involved in the administration of cancer chemotherapy during gestation, as well as to assess the long-term effects on the exposed children. In this retrospective, cohort study, we reviewed the records of women aged 15 to 45 years with a diagnosis of malignancy or benign tumors with malignant behavior at three reference services in the State of Rio Grande do Sul, Brazil, from 1990 to 1997. All patients with a diagnosis of pregnancy at any time during the course of the disease were selected, regardless of whether or not they received specific medication. Fetal outcomes of 14 pregnancies with chemotherapy exposure were compared to that of 15 control pregnancies in which these drugs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Pregnancy; Chemotherapy; Teratogenicity; Fetal outcome.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200007
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Behavioral characteristics of the offspring of adolescent rats BJMBR
Zemunik,T.; Peruzovic,M.; Capkun,V.; Milkovic,K..
The aim of this study was to test the hypothesis that, during adulthood, the offspring of adolescent rats differ in emotionality, learning and memory from the offspring of adult rats. The behavior of the offspring of adolescent (age, 50-55 days) and adult rats (age, 90-95 days) was tested in the open field, activity cage, and passive and active avoidance apparatus. The latencies during training and testing in the passive avoidance apparatus of the offspring of adolescent parents were shorter than the latencies of control offspring (P<0.001 on both training and testing days). Offspring of adolescent parents showed shorter latency time in acquisition trials during active avoidance testing compared to control offspring (P<0.001). They also showed a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adolescence; Pregnancy; Behavior; Learning and memory; Emotionality.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400008
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Chronic Stress Effects on Adrenal Cortex Cellular Proliferation in Pregnant Rats International Journal of Morphology
Bozzo,Aída Andrea; Soñez,Carlos Alberto; Monedero Cobeta,Ignacio; Avila,Rodolfo; Rolando,Alicia Nélida; Romanini,María Cristina; Lazarte,Mario; Gauna,Héctor Fernando; Mugnaini,María Teresa.
Chronic stress by immobilization during pregnancy may cause alterations in mechanisms maintaining homeostasis in the adrenal gland. The objective of this study was to quantify cellular proliferation index in the adrenal cortex during pregnancy second half and assess the effects of chronic stress on it. Adrenal cortex proliferation index in stressed rats showed a significant decrease at 12 and 17 days of gestation, while at day 21 it did not show differences with the control treatments. Moreover, proliferation index of reticular zones in control and experimental rats, exhibited a significant reduction in comparison to glomerular and fascicular zones of adrenal cortex during the three gestation days studied. In conclusion, chronic stress by immobilization...
Tipo: Journal article Palavras-chave: Chronic stress; Cellular proliferation; Adrenal cortex; Pregnancy.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400013
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Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats Biocell
Bozzo,Andrea; Soñez,Carlos Alberto; Mugnaini,María Teresa; Pastorino,Isabel Cecilia; Rolando,Alicia Nélida; Romanini,María Cristina; Gauna,Héctor Fernando.
Chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. The apoptotic index did not present significant differences between the adrenal cortex areas of control and experimental rats in any of the three ages studied. The day of gestation influenced significantly on the apoptotic index in both groups. This index increased as gestation progressed. It may be concluded that chronic stress by immobilization might induce the increase of apoptotic index in adrenal cortex as gestation progresses which might be related variations of plasmatic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic stress; Apoptosis; Adrenal cortex; Pregnancy.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300004
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Colonization by Streptococcus agalactiae during pregnancy: maternal and perinatal prognosis BJID
El Beitune,Patrícia; Duarte,Geraldo; Maffei,Cláudia Maria Leite.
We reviewed colonization by group B Streptococcus beta-haemolyticus of Lancefield (SGB), or Streptococcus agalactiae, in pregnant women, and the consequences of infection for the mother and newborn infant, including factors that influence the risk for anogenital colonization by SGB. We also examined the methods for diagnosis and prophylaxis of SGB to prevent early-onset invasive neonatal bacterial disease. At present, it is justifiable to adopt anal and vaginal SGB culture as part of differentiated obstetrical care in order to reduce early neonatal infection. The rates, risk factors of maternal and neonatal SGB colonization, as well as the incidence of neonatal disease, may vary in different communities and need to be thoroughly evaluated in each country...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pregnancy; Prognosis; Streptococcus agalactiae.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400002
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Combined effect of short stature and socioeconomic status on body mass index and weight gain during reproductive age in Brazilian women BJMBR
Sichieri,R.; Silva,C.V.C.; Moura,A.S..
Short stature, a marker for undernutrition early in life, has been associated with obesity in Brazilian women, but not in men. We tested the hypothesis that weight gain during the reproductive years could explain this gender difference. A national two-stage household survey of mothers with one or more children under five years of age was conducted in Brazil in 1996. The subjects were women aged 20 to 45 years (N = 2297), with last delivery seven months or more prior to the interview. The regions of the country were divided into rural, North/Northeast (urban underdeveloped) and South/Southeast/Midwest (urban developed). The dependent variables were current body mass index (BMI) measured, BMI prior to childbearing (reported), and BMI change. Socioeconomic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Parity; Body mass index; Weight gain; Pregnancy; Overweight; Stature.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000007
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Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age Anais da ABC (AABC)
CORVINO,SILVANA B.; DAMASCENO,DÉBORA C.; SINZATO,YURI K.; NETTO,ALINE O.; MACEDO,NATHÁLIA C.D.; ZAMBRANO,ELENA; VOLPATO,GUSTAVO T..
ABSTRACT The aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Diabetes; Pregnancy; Offspring; Exercise..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100223
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Congenitally transmitted visceral leishmaniasis: report of two brazilian human cases BJID
Mescouto-Borges,Myrlena Regina Machado; Maués,Érika; Costa,Dorcas Lamounier; Pranchevicius,Maria Cristina da Silva; Romero,Gustavo Adolfo Sierra.
Visceral leishmaniasis is a relevant public health problem worldwide. Most of the reported cases in Latin America are from Brazil. Herein we report two human cases of congenitally transmitted visceral leishmaniasis in two patients who developed symptoms during pregnancy. The diagnosis was made by visual examination of Leishmania parasites in bone marrow aspirates of the mothers and by detecting parasite kDNA in bone marrow samples of the newborn children using polymerase chain reaction.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Congenital transmission; Visceral leishmaniasis; Leishmania infantum; Pregnancy.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200024
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Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables BJMBR
Macêdo,G.S.; Ferreira,C.L.P.; Menegaz,A.; Arantes,V.C.; Veloso,R.V.; Carneiro,E.M.; Boschero,A.C.; Oller do Nascimento,C.M.P.; Latorraca,M.Q.; Gomes-da-Silva,M.H.G..
During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Low-protein diet; Pregnancy; Serum leptin; Serum insulin; Body adiposity.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600014
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Cuidados com fêmeas caprinas durante a prenhez e o parto. Infoteca-e
SILVA, E. R. da.
bitstream/item/26719/1/COT-54.pdf
Tipo: Comunicado Técnico (INFOTECA-E) Palavras-chave: Manejo reprodutivo; Brasil; Ceará; Caprino; Reprodução animal; Prenhez; Parto; Goats; Reproduction; Pregnancy; Parturition.
Ano: 1999 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/515275
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Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy BJMBR
Yang,Hui-li; Zhang,Hong-zhi; Meng,Fan-rong; Han,Shu-yi; Zhang,Miao.
Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Even though this decrease was not mimicked in the placenta at the pre-term stage, miR-376c expression was decreased in the plasma of these patients as early as the second trimester. Plasma and placenta specimens were obtained from pregnant women having unifetal gestation undergoing perinatal care between January 2014 and December 2016 (n=49). Early trimester placentas were collected from patients undergoing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Pregnancy; Hypertension; MiR-411; MiR-376c.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400607
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Disruption of reproductive development in male rat offspring following gestational and lactational exposure to di-(2-ethylhexyl) phthalate and genistein Biol. Res.
Zhang,Lian-Dong; Deng,Qian; Wang,Zi-Ming; Gao,Ming; Wang,Lei; Chong,Tie; Li,He-Cheng.
Studies of developmental effects of mixtures of endocrine disrupters on the male reproductive system are of great concern. In this study, the reproductive effects of the co-administration of di-2-(ethylhexyl) phthalate (DEHP) and genistein (GEN) during pregnancy and lactation were studied in male rat offspring. Pregnant Sprague-Dawley rats were gavaged from gestation day 3 to postnatal day 21 with vehicle control, DEHP 250 mg/kg body weight (bwyday, GEN 50 mg/kg bwday, GEN 400 mg/kg bwday, and two combinations of the two compounds (DEHP 250 mg/kg bwday + GEN 50 mg/kg bwday, DEHP 250 mg/kg bwday + GEN 400 mg/kg bwday). The outcomes studied were general morphometry (weight, AGD), testicular histology, testosterone levels, and expression at the mRNA level of...
Tipo: Journal article Palavras-chave: Di-2-(ethylhexyl) phthalate; Genistein; Pregnancy; Lactation; Reproductive system.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200004
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Do socioeconomic factors explain why maternal smoking during pregnancy is more frequent in a more developed city of Brazil? BJMBR
Ribeiro,V.S.; Figueiredo,F.P.; Silva,A.A.M.; Batista,R.L.F.; Barbieri,M.A.; Lamy Filho,F.; Alves,M.T.S.S.B.; Santos,A.M.; Bettiol,H..
The prevalence of smoking during pregnancy in Ribeirão Preto, a rich Brazilian city, was significantly higher (21.4%) than in São Luís (5.9%), a less developed city. To assess which variables explain the difference in prevalence of smoking during pregnancy, data from two birth cohorts were used, including 2846 puerperae from Ribeirão Preto, in 1994, and 2443 puerperae from São Luís, in 1997/98. In multivariable analysis, risk of maternal smoking during pregnancy was higher in São Luís for mothers living in a household with five or more persons (OR = 1.72, 95%CI = 1.12-2.64), aged 35 years or older (OR = 1.98, 95%CI = 0.99-3.96), who had five or more children (OR = 2.10, 95%CI = 1.16-3.81), and whose companion smoked (OR = 2.20, 95%CI = 1.52-3.18). Age of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Smoking; Pregnancy; Risk factors; Perinatal complications; Placenta previa.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000900007
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Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor BJMBR
Ventrucci,G.; Mello,M.A.R.; Gomes-Marcondes,M.C.C..
Cancer patients present high mobilization of host protein, with a decrease in lean body mass and body fat depletion occurring in parallel to neoplastic growth. Since leucine is one of the principal amino acids used by skeletal muscle for energy, we investigated the changes in body composition of pregnant tumor-bearing rats after a leucine-supplemented diet. Sixty pregnant Wistar rats divided into six groups were fed a normal protein diet (18%, N) or a leucine-supplemented diet (3% L-leucine, L). The pregnant groups were: control (CN), Walker 256 carcinoma-bearing rats (WN), control rats pair-fed with tumor-bearing rats (pfN), leucine-supplemented (CL), leucine-supplemented tumor-bearing (WL), and leucine-supplemented rats pair-fed with tumor-bearing rats...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Walker 256 tumor; Pregnancy; Body composition; Leucine; Carcass nitrogen; Diet supplementation.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300006
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Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats Anais da ABC (AABC)
Volpato,Gustavo T.; Francia-Farje,Luis A.D.; Damasceno,Débora C.; Oliveira,Renata V.; Hiruma-Lima,Clélia A.; Kempinas,Wilma G..
Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Citrus aurantium; Essential oil; Limonene; Malformation; Pregnancy; Reproductive outcome.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100407
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Effect of feeding Acacia saligna (Labill.) H.L. Wendl. on goats stabled during late pregnancy and lactation Chilean J. Agric. Res.
Meneses R,Raul; Olivares V,Yohana; Martinoli S,Milenko; Flores P,Hugo.
Acacia saligna (Labill.) H.L. Wendl. forage is an alternative feed supply for goats during dry periods It was used as feed during pregnancy and lactation to evaluate production response and some blood parameters. Six animals in each group were fed with 0, 25, 50, 75, and 100% of acacia as alfalfa (Medicago sativa L.) hay replacement in a completely randomized design. Forage chemical analysis was done to calculate nutrient intake. Blood samples were analyzed for albumin, urea N, globulin, total protein, Ca, and P. Productive parameters were analyzed by ANOVA, Duncan, and regression analyses between acacia and dry matter (DM), crude protein (CP), metabolizable energy (ME), and milk production. Acacia consumption during pregnancy was 65.5% of control,...
Tipo: Journal article Palavras-chave: Acacia saligna; Pregnancy; Lactation; Milk production; Goats; Albumins.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392012000400014
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Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats BJMBR
Rudge,M.V.C.; Damasceno,D.C.; Volpato,G.T.; Almeida,F.C.G.; Calderon,I.M.P.; Lemonica,I.P..
The aim of the present study was to evaluate the effect of Ginkgo biloba treatment (EGb 761, 200 mg kg-1 day-1) administered from day 0 to 20 of pregnancy on maternal reproductive performance and on the maternal and fetal liver antioxidant systems of streptozotocin-induced diabetic Wistar rats. On day 21 of pregnancy, the adult rats (weighing approximately 250 ± 50 g, minimum number = 13/group) were anesthetized to obtain maternal and fetal liver samples for superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and total glutathione (GSH-t) determinations. The uterus was weighed with its contents. The diabetic (G3) and treated diabetic (G4) groups of rats presented significant maternal hyperglycemia, reduced term pregnancy rate,...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Ginkgo biloba; Diabetes mellitus; Pregnancy; Reproductive outcome; Oxidative stress.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800010
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Effect of indomethacin on the pregnant rat BABT
Damasceno,Débora Cristina; Volpato,Gustavo Tadeu; Ferrari,Cássio; Roldan,Luciana B.; Souza,Maricelma da Silva Soares.
The objective of this study was to evaluate the reproductive performance, liver morphological study and post mortem characteristics of the pregnant Wistar rats treated with indomethacin, a general COX inhibitor. Indomethacin at doses of 0 (control), 0.32, 1.68 and 8.40 mg/kg/day were orally given once daily to each group (n=10) on days 3 and 4 of pregnancy (day 0 = first day of pregnancy = positive vaginal sperm). The animals were euthanized under anesthesia on day 11 of pregnancy, and were carried out necropsy and microorganism culture study. The results showed that the doses of 0.32 and 1.68 mg/kg body weight (the therapeutic dose for humans) of indomethacin caused no embryotoxic or lethal effects. The highest dose (8.40 mg/kg) of indomethacin disturbed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Indomethacin; COX; Pregnancy; Rat; Implantation.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000100010
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