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Although it induces synchronized ovulation, hCG reduces the fertility of Santa Ines ewes submitted to TAI Arq. Bras. Med. Vet. Zootec.
Dias,L.M.K.; Sales,J.N.S.; Viau,P.; Barros,M.B.P.; Nicolau,S.S.; Simões,L.M.S.; Alves,N.G.; Alonso,M.A.; Valentim,R.; Oliveira,C.A..
ABSTRACT The aim of this study was to evaluate hCG treatment on ovarian response and on pregnancy rate using a 9-day oestrus synchronization protocol in Santa Ines ewes. On a random oestrus cycle day, ewes received an intravaginal progesterone device (Primer-PR®, Tecnopec, Brazil). Nine days later (Day 9), 30µg of d-cloprostenol (Prolise®, Syntex, Argentina) and 250IU of eCG (Folligon®, Intervet, Brazil) were administered and the progesterone device was removed. This moment, the ewes were randomly assigned on two groups: Control Group and hCG Group. In the hCG Group, the ewes received 500IU of hCG (Vetecor®, Hertape-Calier, Spain) 24h after device removal. In the Control Group, the ewes did not receive any ovulation inductor. Control and hCG Groups ewes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Progesterone; Follicle; Ovulation; Synchronization.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000100122
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Atividade ovariana pós-parto em ovelhas Santa Inês sob diferentes manejos de amamentação na região semiárida do Nordeste. Repositório Alice
ELOY, A. M. X.; SOUZA, P. H. F. de; SIMPLICIO, A. A..
Objetivou-se investigar o efeito de diferentes manejos de amamentação sobre a atividade ovariana pós-parto em ovelhas da raça Santa Inês por meio das concentrações circulantes de progesterona. Foram utilizadas 18 fêmeas com idade entre 22 e 72 meses. Após o parto, os cordeiros ficaram com as ovelhas até o 14º diae, a partir do 15º dia foram distribuídas em dois grupos: amamentação contínua (n=9) e controlada (n=9). As coletas de sangue para a dosagem de progesterona aconteceram a cada sete dias a partir do parto até o primeiro estro e, em seguida, a cada quatro dias até o segundo estro. Houve atividade ovulatória silenciosa antes do primeiro estro pós-parto em 85,70% (5/9) e 25% (3/9) das fêmeas em amamentação contínua e controlada, respectivamente. As...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Raça Santa Inês; Ovino; Ciclo estral; Pós-parto; Progesterona; Reprodução animal; Sheep; Reproduction; Perinatal period; Progesterone; Oestrous cycle.
Ano: 2011 URL: http://www.alice.cnptia.embrapa.br/handle/doc/912991
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Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats BJMBR
Souza,M.F.; Couto-Pereira,N.S.; Freese,L.; Costa,P.A.; Caletti,G.; Bisognin,K.M.; Nin,M.S.; Gomez,R.; Barros,H.M.T..
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol (0.05 mg/mL), progesterone plus estradiol, or the oil vehicle. Sham-operated control females received oil. Control and acute subgroups received injections of saline, while the repeated group received cocaine (15 mg/kg, ip) for 8 days. After 10 days, the acute and repeated groups received a challenge dose of cocaine, after which locomotion and stereotypy were monitored. The estrous cycle phase was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cocaine; Locomotor activity; Female rats; Estradiol; Progesterone; Stereotypic activity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600505
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Changes in Plasma Metabolic Hormone Concentrations During the Ovarian Cycles of Japanese Black and Holstein Cattle OAK
KAWASHIMA, Chiho; KIDA, Katsuya; HAYASHI, Ken-Go; AMAYA MONTOYA, Carlos; KANEKO, Etsushi; MATSUNAGA, Nobuyoshi; SHIMIZU, Takashi; MATSUI, Motozumi; MIYAKE, Yoh-Ichi; SCHAMS, Dieter; MIYAMOTO, Akio; 川島, 千帆; 木田, 克弥; 清水, 隆; 松井, 基純; 三宅, 陽一; 宮本, 明夫.
The aim of the present study was to investigate the changing profiles of plasma metabolic hormones during the ovarian cycles of beef and dairy cattle. We used 16 non-pregnant, non-lactating Japanese Black beef cattle (6 heifers and 10 cows; parity=2.3 ± 0.8) and 12 multiparous Holstein dairy cows (parity=3.0 ± 0.3). Blood samples for hormonal analysis (growth hormone, GH; insulin-like growth factor-I, IGF-1; insulin; and progesterone, P4) were obtained twice weekly for 40 days before artificial insemination for Japanese Black cattle and from 50 to 100 days postpartum for Holstein cows. Luteal phases were considered normal if the P4 concentrations for at least 3 time points over the course of 7 days remained above 1 ng/ml and at least 2 of the time points...
Palavras-chave: Cattle; Insulin-like growth factor-I; Ovarian cycle; Progesterone.
Ano: 2007 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2984
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Changes of Progesterone and Endothelin Concentrations in the Peripheral Plasma of Female Calves and Cycling Cows: Effects of PGF2α Injection OAK
OHTANI, Masayuki; OKI, Naoko; TANIMURA, Miyune; KOBAYASHI, Shu-ichi; ACOSTA, Tomas J.; HAYASHI, Kanako; MIYAMOTO, Akio; 宮本, 明夫.
It is well known that an injection of prostaglandin F2α (PGF2α) or its analogue during the mid luteal phase of the estrous cycle induces a rapid decrease in plasma progesterone (P4) concentration, followed by luteolysis in the cow. There is evidence that a potent vasoactive peptide, endothelin-1 (ET-1), is produced in the bovine corpus luteum (CL), and that it is directly involved in luteolysis. We previously found that ET-1 concentrations in the peripheral plasma increase during the period of luteolysis and ovulation in cows. However, it is not clear whether the elevation of peripheral plasma ET-1 concentration observed during luteolysis and ovulation originates exclusively from the ovary and/or CL. Such a profile of plasma ET-1 concentration may be...
Palavras-chave: Endothelin; Progesterone; Plasma; Calves; Cows.
Ano: 2001 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2973
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Characterization of progesterone loaded biodegradable blend polymeric nanoparticles Ciência Rural
Leimann,Fernanda Vitória; Biz,Maiara Heloisa; Kaufmann,Karine Cristine; Maia,Wallace José; Honçalves,Odinei Hess; Cardozo Filho,Lucio; Sayer,Claudia; Araújo,Pedro Henrique Hermes de.
ABSTRACT: The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV/PLLA blend nanoparticles was investigated in this research. Nanoparticles were produced by miniemulsion/solvent evaporation technique with lecithin as surfactant and were characterized regarding to z-average diameter (Dz) and polydispersity (PDI), progesterone recovery yield and encapsulation efficiency. Possible interactions between progesterone and the polymer matrices were investigated by Fourier Transform Infrared Spectroscopy (FTIR). High recoveries (up to 102.43±1.80% for the PHBV/PLLA blend) and encapsulation efficiencies (up to 99.53±0.04% for PCL) were achieved...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Progesterone; Drug-polymer interactions; PHBV; PLLA; PCL.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015001102082
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Clinical and pathological study of feline mammary fibroadenomatous change associated with depot medroxyprogesterone acetate therapy Arq. Bras. Med. Vet. Zootec.
Loretti,A.P.; Ilha,M.R.S.; Breitsameter,I.; Faraco,C.S..
Descrevem-se seis casos de alteração fibroadenomatosa mamária felina (AFAMF) associada à administração de uma única injeção de acetato de medroxiprogesterona (AMP) na dose recomendada pelos fabricantes. A doença foi observada em gatas jovens não-castradas atendidas em dois hospitais veterinários de 1999 a 2001. O diagnóstico de AFAMF foi feito com base no histórico, sinais clínicos e achados macroscópicos e confirmado histologicamente em quatro dos seis casos. Sugere-se que a ocorrência da AFAMF esteja associada ao efeito prolongado de uma única injeção de AMP de depósito administrada em situações nas quais o emprego dessa terapia não é recomendado.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Cat; Feline mammary fibroadenomatous change; Progesterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000200020
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Cloprostenol administration in the first week postpartum reduces expression of oxytocin receptors in the endometrium in Holstein-Zebu cows. Repositório Alice
CAMARGOS, A.; WOHLRES-VIANA, S.; COSTA, I. F.; CAMARGO, L. S. de A.; FERREIRA, J. C.; RAMOS, A. A.; OBA, E..
ABSTRACT The present study investigated the hormonal profile and expression of prostaglandin F2? (PGF2?), oxytocin and estrogen receptors in uterine tissues of postpartum cows treated with cloprostenol. Twenty HolsteinZebu crossbred cows were treated with saline solution (treatment CONT) or cloprostenol (treatment CLO), both administered two and five days postpartum. Blood samples were collected on days two, seven, 14, 21 and 28 postpartum for progesterone, PGF2? metabolite (PGFM) and estradiol determination, and endometrial biopsy was performed in order to quantify the expression of oxytocin receptor (OXTR), prostaglandin F receptor (PTGFR) and estrogen receptor 1 (ERS1) genes. In the CLO treatment, expression of OXTR was reduced (P<0.05) but no...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: PTGFR; ESRI; Progesterone; Estradiol; RT-PCR.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1085645
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Cloprostenol administration in the first week postpartum reduces expression of oxytocin receptors in the endometrium in Holstein-Zebu cows Arq. Bras. Med. Vet. Zootec.
Camargos,A.; Wohlres-Viana,S.; Costa,I.F.; Camargo,L.S.; Ferreira,J.C.; Ramos,A.A.; Oba,E..
ABSTRACT The present study investigated the hormonal profile and expression of prostaglandin F2α (PGF2α), oxytocin and estrogen receptors in uterine tissues of postpartum cows treated with cloprostenol. Twenty Holstein-Zebu crossbred cows were treated with saline solution (treatment CONT) or cloprostenol (treatment CLO), both administered two and five days postpartum. Blood samples were collected on days two, seven, 14, 21 and 28 postpartum for progesterone, PGF2α metabolite (PGFM) and estradiol determination, and endometrial biopsy was performed in order to quantify the expression of oxytocin receptor (OXTR), prostaglandin F receptor (PTGFR) and estrogen receptor 1 (ERS1) genes. In the CLO treatment, expression of OXTR was reduced (P<0.05) but no...
Tipo: Info:eu-repo/semantics/article Palavras-chave: PTGFR; ESR1; Progesterone; Estradiol; RT-PCR.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000400821
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Comparison of serum hormone levels of captive and free-living maned wolves Chrysocyon brachyurus BJMBR
Maia,O.B.; Jácomo,A.T.A.; Bringel,B.A.; Kashivakura,C.K.; Oliveira,C.A.; Teodoro,L.O.F.; Silveira,L.; Teixeira da Costa,M.E.L.; Malta,M.C.C.; Furtado,M.M.; Torres,N.M.; Mattos,P.S.R.; Viau,.P; Lima,T.F.G.; Morato,R.G..
Serum hormone levels were compared between captive and free-living maned wolves and seasonal variations of sex hormones were studied. Blood samples were collected from 16 male and 26 female adult animals from Brazilian zoos, and from 30 male and 24 female free-living adults to determine serum progesterone and testosterone by radioimmunoassay. Serum testosterone concentrations varied (P < 0.05) across seasons for 16 captive males, being higher in autumn (2184.7 ± 355.1 pg/mL) than in summer (1080.7 ± 205.4 pg/mL), winter (1270.1 ± 276.6 pg/mL) and spring (963.9 ± 248.1 pg/mL), although they did not differ between summer, winter and spring. Testosterone concentration of 30 free-living males differed (P < 0.05) between autumn (824.1 ± 512.2 pg/mL),...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Maned wolf Chrysocyon brachyurus; Progesterone; Testosterone; Radioimmunoassay; Reproduction.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200015
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Conception rate in Holstein cows treated with GnRH or hCG on the fifth day post artificial insemination during summer Arq. Bras. Med. Vet. Zootec.
Beltran,M.P.; Vasconcelos,J.L.M..
Lactating Holstein cows (n=158), at 213±112 days in milking and averaging 26±9kg of milk per day, were randomly assigned to one of three treatment groups: control (CG, n=52, saline), GnRH (GG, n=55, 100g gonadorelin), and hCG (HG, n=51, 2500IU) given five days after artificial insemination (AI). Rectal temperature was taken at the moment of AI and blood samples were collected five, seven, and 12 days after AI. Pregnancy was determined between 42 and 49 days after AI. Concentration of progesterone (P4) in serum (ng/ml, mean±SE) for CG, GG, and HG were, respectively, 2.7±0.4, 2.5±0.4, and 3.2±0.5 on day 5; 4.8±0.4, 4.2±0.4, and 5.7±0.5 on day 7; and 5.2±0.4, 6.9±0.4, and 8.5±0.5 on day 12 after AI. P4 concentration had proportional increase in serum between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dairy cow; Conception; Progesterone; HCG; GnRH.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300009
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Desempenho reprodutivo de cabras Alpinas tratadas com hCG cinco dias após o acasalamento. Repositório Alice
FONSECA, J. F. da; TORRES, C. A. A.; MAFFILI, V. V.; BORGES, A. M.; ESPESCHIT, C. J. B.; BALBINOT, P. de Z.; OLIVEIRA, R. F. M.; LEITE, P. A. G..
Objetivou-se com este estudo avaliar o efeito da administração de hCG sobre o desempenho reprodutivo de cabras Alpinas i durante a estação de acasalamento natural. Trinta e duas fêmeas nulíparas e 124lactantes, após a identificação de estro e acasalamento, foram aleatoriamente divididas, de acordo com a categoria, em dois tratamentos. Em TI (n=75) e T2 (n=81), os animais receberam I roL de solução salina ou 250 UI de hCG, respectivamente, por via intramuscular cinco dias após o acasalamento. A gestação foi verificada por ultra-sonografia transabdominal (probe de 3,5 MHz) nos dias 35 e 70 após o acasalamento, para detecção e confirmação da gestação, respectivamente. As taxas de gestação não diferiram entre TI (86,7%) e T2 (70,6%) para nulíparas e TI (78,3...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Caprino; Raça Alpina; Reprodução animal; Desempenho reprodutivo; Eficiência reprodutiva; Acasalamento; HCG; Dairy Goat; Reproductive performance; Corpus luteum; Progesterone; Pregnancy rate; Estrous cycle.
Ano: 2005 URL: http://www.alice.cnptia.embrapa.br/handle/doc/531515
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Differences in progesterone concentrations and mRNA expressions of progesterone receptors in bovine endometrial tissue between the uterine horns ipsilateral and contralateral to the corpus luteum OAK
TAKAHASHI, Hiroto; HANEDA, Shingo; KAYANO, Mitsunori; MATSUI, Motozumi; 羽田, 真悟; 茅野, 光範; 松井, 基純.
Because the establishment of pregnancy begins at the uterine horn ipsilateral to the corpus luteum (ipsi-horn) in cattle, levels of progesterone (P4) and receptor expression in the endometrial tissue, which regulate the intrauterine environment for embryo development, may differ between the ipsi-horn and the uterine horn contralateral to corpus luteum (contra-horn). The aim of the present study was to determine the endometrial tissue P4 concentrations and nuclear progesterone receptor (PGR), progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 mRNA expressions in the cranial and middle parts of the uterine horns during the luteal phase. The results showed higher endometrial tissue P4 concentrations in the cranial part of the ipsi-horn than in...
Palavras-chave: Bovine; Progesterone; Receptor; Uterus.
Ano: 2016 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4364
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Different stress modalities result in distinct steroid hormone responses by male rats BJMBR
Andersen,M.L.; Bignotto,M.; Machado,R.B.; Tufik,S..
Since both paradoxical sleep deprivation (PSD) and stress alter male reproductive function, the purpose of the present study was to examine the influence of PSD and other stressors (restraint, electrical footshock, cold and forced swimming, N = 10 per group) on steroid hormones in adult Wistar male rats. Rats were submitted to chronic stress for four days. The stressors (footshock, cold and forced swimming) were applied twice a day, for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day whereas PSD was continuous. Hormone determination was measured by chemiluminescent enzyme immunoassay (testosterone), competitive immunoassay (progesterone) and by radioimmunoassay (corticosterone, estradiol, estrone)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paradoxical sleep deprivation; Stress; Testosterone; Progesterone; Estrogen; Corticosterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600003
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Early embryonic death in mares: clinical and hormonal aspects Braz. J. Vet. Res. Anim. Sci.
PAPA,Frederico Ozanam; LOPES,Maria Denise; ALVARENGA,Marco Antonio; MEIRA,Cezinande de; LUVIZOTTO,Maria Cecília Rui; LANGONI,Hélio; RIBEIRO,Erley Felix; AZEDO,Antonio Esteves; BOMFIM,Antonio Carlos de Miranda.
The present study aimed to diagnose early embryonic death in 128 mares. Blood samples were collected at the 4th, 7th, 10th, 13th, 16th, 19th, 21st and 30th day after ovulation and the diameter of the corpus luteum was measured. The diameter and characteristics of the embryonic vesicle were evaluated by ultrasonography. Microbiology, cytology and histopathology were carried out in mares with embryonic death. Plasma oestrogen and progesterone concentration were measured by radioimmunoassay. From 128 mares, 17 (13.28%) showed early embryonic death. The embryonic losses took place at 19 days of pregnancy in 47.05% and at 21 days of pregnancy in 29.4% of the mares. The diameter of the corpus luteum in the mares that maintained pregnancy was similar to those...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Embryo mortality; Progesterone; Estrogen; Histopathology; Equine.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95961998000400005
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Effect of Bone Morphogenetic Protein 6 (BMP6) on Chicken Granulose Cells Proliferation and Progesterone Synthesis Rev. Bras. Ciênc. Avic.
Yang,F; He,L; Luo,B; Ye,F; Cui,C; Yu,X; Xu,H; Zhao,X; Yin,H; Li,D; Zhu,Q; Wang,Y.
ABSTRACT There is increasing evidence that bone morphogenetic protein 6 (BMP6) plays critical roles in regulating various stages of ovarian follicle development in mammals. However, the mechanisms of regulation of BMP6 in the chicken ovary remain unclear. In this study, mRNA and protein expression level of BMP6 in chicken ovarian follicles at different development stages were determined by qRT-PCR and western blot separately. Different concentrations of BMP6 protein and FSH were added to the culture medium, and the effects to proliferation of granulose cells were detected, further effect on expression pattern of progesterone synthesis associated genes were also analyzed by qRT-PCR and Western blotting and the secretion of progesterone was detected by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chicken; BMP6; Granulosa cells; Progesterone; FSH.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000200310
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Effect of Bovine Somatotropin Administration on Day 11 after Artificial Insemination in Estrus-Induced Ewes during the Non-Breeding Season OAK
Fukui, Yutaka; Yamamura, Kunio; Matsunaga, Nobuyoshi; Miyamoto, Akio; 福井, 豊; 宮本, 明夫.
The present study aimed to examine the possibility that bovine somatotropin (BST) treatment after artificial insemination (AI) may improve the fertility by the stimulation of corpus luteum (CL) function in seasonally anestrous ewes. The experiment was conducted at the Tawa Field Station, Shibecha-cho in Hokkaido, Japan, during the non-breeding season (May, 1995). Eighty-nine mature (2 to 3 years old) Suffolk and Suffolk-crossed ewes were treated with controlled internal drug release devices containing 0.3 g progesterone (CIDR-G) for 12 days. Ewes were injected intramuscularly with 500 IU PMSG the day before CIDR removal. Eighty-seven ewes were assigned to an insemination of frozen semen on a fixed-time basis (42 to 50 h) after removal of CIDR. On the 11th...
Palavras-chave: Bovine somatotropin; Artificial insemination; Progesterone; Conception rate; Ewes.
Ano: 2000 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2971
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Effect of breed and corpus luteum on pregnancy rate of bovine embryo recipients R. Bras. Zootec.
Nogueira,Ériklis; Cardoso,Gabriel Saravi; Marques Junior,Heitor Romero; Dias,Alexandre Menezes; Ítavo,Luís Carlos Vinhas; Borges,Juliana Corrêa.
The objective of this study was to evaluate pregnancy rates of recipients of different breed groups (Nellore and crossbreed), as well as the effects of size and type of the corpus luteum (CL) on plasmatic concentrations of progesterone and pregnancy rates of embryo recipients. A total of 152 heifers were synchronized with progesterone implants and on the day of embryo transfer, previously obtained by superovulation and frozen in ethylene glycol, the diameter and type of the corpus luteum (cavitary and compact) was measured and blood was collected for progesterone measurement. The pregnancy rate was 44.1%, with a diameter of corpus luteum higher in recipients that became pregnant (2.03±0.41) compared with non-pregnant ones (1.86±0.34 cm). Plasmatic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cavitary corpus luteum; Nellore; Progesterone; Ultrasound.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982012000900022
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Effect of circulating progesterone on in vitro developmental competence of bovine oocytes. Repositório Alice
PFEIFER, L. F. M.; SARTORI, R.; PIVATO, I.; RUMPF, R.; NOGUEIRA, G. P.; XAVIER, E. G.; DIONELLO, N. J. L.; CORRÊA, M. N..
bitstream/item/178597/1/SP-19872-ID-32317.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: In vitro embryo production; Oocyte; Progesterona; Cattle; Progesterone.
Ano: 2009 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/662268
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Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats BJMBR
Moreira,R.M.; Borges,P.P.; Lisboa,P.C.; Curty,F.H.; Moura,E.G.; Pazos-Moura,C.C..
Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. The treatment of adult OVX rats with MPA (0.25 mg/100 g body weight, sc, daily for 9 days) induced a significant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medroxyprogesterone acetate; Progesterone; Thyrotropin; Aging; Ovariectomy; Thyrotropin-releasing hormone.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900020
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