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A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat BJMBR
Bonilha,A.M.M.; Saraiva,R.M.; Kanashiro,R.M.; Portes,L.A.; Antonio,E.L.; Tucci,P.J.F..
Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction size; Rats; Electrocardiogram; Echocardiogram; ROC curve.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400016
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ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS Acta Amazonica
NAKAYAMA,Luiza; SOUZA,José Silva de; OHASHI,Otávio Mitio; VALE,WiIiam G..
The tea made from the infrutescense (corresponding to the edible part plus its cover) of ananai (Ananas ananassoidesBAK.) was administered to pregnant rats, during the period of embryos implantation (5th - 6th day through pregnancy). The animals were slaughtered on the 14th - 15th day through the pregnancy and average rates of implantation and resorption were stimated.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Abortifacient; Reproduction control; Ananai; Rats.
Ano: 1993 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59671993000100077
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Acceleration of reflex maturation and physical development in suckling rats: effects of a maternal diet containing lipids from goat milk. Repositório Alice
SOARES, J. K. B.; QUEIROGA, R. de C. R. do E.; BOMFIM, M. A. D.; PESSOA, D. C. N. de P.; BARBOSA, E. de A.; SOUZA, D. L.; CABRAL-FILHO, J. E.; MEDEIROS, M. do C..
Objective: To investigate the effects of lipids from goat milk containing conjugated linoleic acids on body weight and reflex ontogeny of neonatal rats treated during the prenatal and suckling periods. Methods: Three groups were studied: soybean oil (S), coconut oil (C), and goat milk lipids (GM). Reflex maturation (palm grasp, righting reflex, cliff avoidance, vibrissae placing, negative geotaxis, auditory startle, and free-fall righting) as well as body weight evolution were recorded during lactation. Results: Data demonstrated that the lipids from goat milk accelerated body weight evolution as well as all the reflex maturation investigated (P < 0.05). Discussion: The supply of goat?s milk offered to Wistar rats during pregnancy and lactation provided...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Conjugated linoleic acid; Maternal nutritional; Leite de cabra; Caprino; Aleitamento; Lactação; Óleo vegetal; Soja; Dieta; Gordura; Prenhez; Coco; Cérebro; Ganho de peso; Goat milk; Goats; Rats; Weight; Suckling; Linoleic acid; Lactation; Dosage effects; Drugs; Plant oils; Pregnancy; Soybean oil; Fats; Coconut oil; Brain.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1005386
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Acute blood volume expansion delays the gastrointestinal transit of a charcoal meal in awake rats BJMBR
de-Oliveira,G.R.; Gondim,F. de-A.A.; da-Graça,J.R.V.; Xavier-Neto,J.; Dantas,R.P.; Gondim,R.B.M.; Santos,A.A.; Rola,F.H..
The present study evaluates the effect of blood volume expansion on the gastrointestinal transit of a charchoal meal (2.5 ml of an aqueous suspension consisting of 5% charcoal and 5% gum arabic) in awake male Wistar rats (200-270 g). On the day before the experiments, the rats were anesthetized with ether, submitted to left jugular vein cannulation and fasted with water ad libitum until 2 h before the gastrointestinal transit measurement. Blood volume expansion by iv infusion of 1 ml/min Ringer bicarbonate in volumes of 3, 4 or 5% body weight delayed gastrointestinal transit at 10 min after test meal administration by 21.3-26.7% (P&lt;0.05), but no effect was observed after 1 or 2% body weight expansion. The effect of blood volume expansion (up to 5%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypervolemia; Blood volume; Gastrointestinal transit; Rats; Gastrointestinal motility.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600017
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Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats International Journal of Morphology
Zafar,Muhammad; Naeem-ul-Hassan Naqvi,Syed; Ahmed,Masood; Kaimkhani,Zahid Ali.
We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association between diabetic kidney complications and kidney enzyme alterations. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians &amp; Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty (80) albino rats were divided into five...
Tipo: Journal article Palavras-chave: Streptozotocin; Aminotransferases; Alkaline phosphatase; Pseudocholinesterase; STZ-diabetes; Rats.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300024
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Amylomyces rouxii Strain CBS 438.76 Affects Cholesterol Metabolism in Cholesterol-Fed Rats OAK
FUKUSHIMA, Michihiro; HAN, Kyu-Ho; TANEICHI, Yae; IIJIMA, Setsuko; SHIMADA, Ken-ichiro; SAITOH, Katsuichi; ODA, Yuji; CHIJI, Hideyuki; SEKIKAWA, Mitsuo; 福島, 道広; 韓, 圭鎬; 島田, 謙一郎; 小田, 有二; 関川, 三男.
We examined the effects of Amylomyces rouxii, which is a mold found in some fermented foods in Indonesia, on serum cholesterol and hepatic LDL receptor mRNA in rats. Rats were fed a 0.5% cholesterol-enriched diet with (A. rouxii group) or without (control group) 30g/kg A. rouxii for 4 wk. There were no significant differences in the body weight, food intake or liver weight among the groups. However, the weight of the cecum in the A. rouxii-fed group was significantly higher than that in the control group. The cecal pH in the A. rouxii-fed group was significantly lower than that in the control group. Cecal acetic acid, propionic acid and total SCFA concentrations in the A. rouxii-fed group were significantly higher than those in the control group. The serum...
Palavras-chave: Rats; Amylomyces rouxii strain CBS 438.76; Cholesterol; Cholesterol 7α-hydroxylase mRNA; LDL receptor mRNA.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2911
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Amylose content in rice (Oryza sativa) affects performance, glycemic and lipidic metabolism in rats Ciência Rural
Denardin,Cristiane Casagrande; Boufleur,Nardeli; Reckziegel,Patrícia; Silva,Leila Picolli da; Walter,Melissa.
This research aimed at evaluating the effect of diets with high, intermediate and low amylose content of rice on performance, glycemic and lipidic metabolism in rats. Male Wistar rats were fed diets with grains of cooked rice of the cultivars 'IRGA 417', 'IRGA 416' and 'MOCHI' with high, intermediate and low amylose content, respectively. Wet and dry fecal production and serum HDL cholesterol were not affected by amylose content. The animals in the treatments with high amylose content ('IRGA 417') presented lower feed intake, body weight gain and apparent digestibility, higher fecal water content and nitrogen excretion, reduced fecal pH, lower postprandial blood glucose response, serum total cholesterol and triglycerides levels and pancreas weight, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rice grains; Hyperglycemia; Metabolic responses; Rats.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000200030
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Análise de dados longitudinais de ganhos de peso de ratas durante a gestação: avaliação do efeito de um nanocomposto. Repositório Alice
OLIVEIRA, L. P. de; LIMA, C. G. de; CASTRO, V. L. S. S. de; MAIA, A. de H. N..
Para avaliar a segurança de um produto químico para a saúde são necessários testes toxicológicos realizados, na maioria das vezes, com ratos. Nesse trabalho, avaliou-se os efeitos da ingestão diária de doses de um nanocomposto no ganho de peso de ratas durante o período de gestação. Os ganhos de pesos diários apresentaram bastante variação ao longo do período e padrões diferentes ao longo das semanas. Dessa forma, os perfis médios de pesos foram descritos usando regressão spline quadrática, com dois pontos de mudança fixados em intervalos semanais. Essa abordagem apresenta vantagens, tanto do ponto de vista de análise de dados, pela maior simplicidade dos modelos lineares nos parâmetros, como também do ponto de vista de interpretação prática, uma vez que...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Rato; Período de Gestação; Rats; Nanocomposites.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1116385
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Analysis of fracture healing in osteopenic bone caused by disuse: experimental study BJMBR
Paiva,A.G.; Yanagihara,G.R.; Macedo,A.P.; Ramos,J.; Issa,J.P.M.; Shimano,A.C..
Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture healing has been investigated in several previous studies because there is still controversy over the effect osteoporosis has on the healing process. The current study aimed to analyze two different periods of bone healing in normal and osteopenic rats. Sixty, 7-week-old female Wistar rats were randomly divided into four groups: unrestricted and immobilized for 2 weeks after osteotomy (OU2), suspended and immobilized for 2 weeks after osteotomy (OS2), unrestricted and immobilized for 6 weeks after osteotomy (OU6), and suspended and immobilized for 6 weeks after osteotomy (OS6). Osteotomy was performed in the middle third of the right tibia 21 days after tail...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Osteoporosis; Osteotomy; Fracture healing; Immobilization; Rats.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300708
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Assessment of the risks of rats (Rattus norvegicus) and opossums (Didelphis albiventris) in different poultry-rearing areas in Argentina BJM
Villafañe,Isabel E. Gómez; Miñarro,Fernando; Ribicich,Mabel; Rossetti,Carlos A.; Rossotti,Daniel; Busch,María.
We have studied the prevalence of Trichinella spiralis, Leptospira spp. and Salmonella spp. in rats and opossums that inhabit poultry farms of Exaltación de la Cruz, Buenos Aires, Argentina, to determine the potential sanitary risk for humans that are in contact with these animals. The study was carried out on 48 poultry farms between spring 1999 and winter 2001. The study of opossums began in winter 2000. During the study period we captured 152 Rattus norvegicus, 3 Rattus rattus, 16 Didelphis albiventris and 1 Lutreolina crassicaudata. We have registered the presence of rats and opossums in 70% and 27% of the studied farms, respectively. The percentage of farms with rats was independent of the presence or absence of pigs. We did not detect the presence of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zoonosis; Salmonella; Poultry farms; Rats; Opossum.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300017
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Behavioral alterations induced by repeated saxitoxin exposure in drinking water J. Venom. Anim. Toxins incl. Trop. Dis.
Diehl,Felipe; Ramos,Patricia Baptista; Santos,Juliane Marques dos; Barros,Daniela Martí; Yunes,João Sarkis.
Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats. Methods The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Saxitoxin; Drinking water; Behavior; Aversive memory; Spatial memory; Rats.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314
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Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats BJMBR
Conceição,C.Q.; Engi,S.A.; Cruz,F.C.; Planeta,C.S..
The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Pre-clinical evidence shows that there are interactions between testosterone and psychoactive drugs, such as cocaine. However, few studies have been performed to investigate the effect of repeated testosterone treatment on behavioral effects of amphetamine derivatives, such as fenproporex. The purpose of the present study was to investigate the effects of repeated testosterone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Behavioral sensitization; Fenproporex; Testosterone; Rats.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100603
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Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats BJMBR
Banin,R.M.; Hirata,B.K.S.; Andrade,I.S.; Zemdegs,J.C.S.; Clemente,A.P.G.; Dornellas,A.P.S.; Boldarine,V.T.; Estadella,D.; Albuquerque,K.T.; Oyama,L.M.; Ribeiro,E.B.; Telles,M.M..
Ginkgo biloba extract (GbE) has been indicated as an efficient medicine for the treatment of diabetes mellitus type 2. It remains unclear if its effects are due to an improvement of the insulin signaling cascade, especially in obese subjects. The aim of the present study was to evaluate the effect of GbE on insulin tolerance, food intake, body adiposity, lipid profile, fasting insulin, and muscle levels of insulin receptor substrate 1 (IRS-1), protein tyrosine phosphatase 1B (PTP-1B), and protein kinase B (Akt), as well as Akt phosphorylation, in diet-induced obese rats. Rats were fed with a high-fat diet (HFD) or a normal fat diet (NFD) for 8 weeks. After that, the HFD group was divided into two groups: rats gavaged with a saline vehicle (HFD+V), and rats...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ginkgo biloba extract; Obesity; Insulin tolerance; Body adiposity; Akt phosphorylation; Rats.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900780
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Blood glucose regulation during fasting in rats under food restriction since birth BABT
Vitoriano,Adriana de Souza; Malta,Ananda; Barrena,Helenton Christian; Furlan,Maria Montserrat Diaz Pedrosa; Bazotte,Roberto Barbosa; Gazola,Vilma Godoi.
The effect of severe food restriction since birth on regulation of fasting glycemia in male Wistar rats was investigated. The control group (CG) had free supply of chow, while the restriction group (RG) received 50% of the amount ingested by the CG. The experiments were done in adult (60 days) overnight fasted rats in which glycemia, liver free glucose levels and hepatic glycogen concentration were measured. In part of the experiments in situ liver perfusion was done. The results showed that livers from the RG had higher glycogenolysis rates but lower gluconeogenesis rates from L-alanine (10 mM). Since RG showed maintained glycemia during fasting, it could be concluded that livers from RG produced glucose preferentially from glycogenolysis in detriment of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food restriction; Rats; Liver; Gluconeogenesis; Glycogenolysis.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100009
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Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats. Repositório Alice
ALMEIDA, M. M. de; LUQUETTI, S. C. P. D.; SABARENSE, C. M.; CORRÊA, J. O. do A.; REIS, L. G. dos; CONCEIÇÃO, E. P. S. da; LISBOA, P. C.; MOURA, E. G. de; GAMEIRO, J.; GAMA, M. A. S. da; LOPES, F. C. F.; GARCIA, R. M. G..
Feeding rats on a high-fat diet containing butter naturally enriched in cis-9, trans-11 CLA prevented hyperinsulinemia and increased HDL cholesterol, which could be associated with higher levels of cis-9, trans-11 CLA, vaccenic acid, oleic acid and lower levels of short and medium-chain saturated fatty acids from butter naturally modified compared to control butter. On the other hand CLA-enriched butter also increased serum triacylglycerol levels, which could be associated with concomitant increases in the content of trans-9 and trans-10 C18:1 isomers in the CLA-enriched butter.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: High conjugated linoleic acid enriched butter; Functional food; Rats; Insulin sensitivity; Dyslipidemia; Diabetes.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1006276
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Calcium bioavailability of raw and extruded amaranth grains Ciênc. Tecnol. Aliment.
Ferreira,Tania Aparecida; Arêas,José Alfredo Gomes.
Calcium bioavailability of raw and extruded amaranth grains was assessed in a biological assay in rats. Rats were fed for 28 days on diets in which raw or extruded amaranth was the only calcium source, compared to a control diet with calcium carbonate. Calcium and phosphorous levels were determined in the rats' serum during the experimental period and in the bones at the end of the experiment. Amaranth extrusion increased its calcium bioavailability, assessed by tibia and femur weights and calcium and phosphorous content of the bones. Apparent calcium absorption index, the force needed to break the bones and bone densitometry of both extruded and raw amaranth were the same, though different from the control group. The results show that amaranth can be a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Novel foods; Densitometry; Calcium absorption; Rats; Antinutritional factors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612010000200037
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Can calories from ethanol contribute to body weight preservation by malnourished rats? BJMBR
Aguiar,A.S.; Da-Silva,V.A.; Boaventura,G.T..
Our objective was to compare the use of calories from ethanol by well-nourished and malnourished rats in terms of body weight. Female Wistar rats weighing 170-180 g at the beginning of the study were used. The animals were divided into two groups (N = 12 each): group W received water ad libitum and group E an ethanol solution ad libitum as the only source of liquid throughout the experiment. The concentration of ethanol was increased weekly from 0 to 5, 10, 20 and 40% (v/v). In the well-nourished phase (A), all rats received food ad libitum (AW and AE). Ethanol treatment (AE) was then interrupted and water was offered to both groups. After 2 weeks both AW and AE rats were submitted to food restriction (50% of group AW food consumption), thus initiating the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Ethanol; Weight gain; Malnutrition; Rats; Toxicity.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600009
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Cardiorespiratory evaluation of juvenile rats experimentally envenomed with Tityus serrulatus venom J. Venom. Anim. Toxins incl. Trop. Dis.
Pinto,MCL; Melo,MB; Cruz,ML; Verçosa Junior,D; Melo,MM.
Accidental envenomation caused by Tityus serrulatus scorpions is very common in Brazil and may result in serious cardiorespiratory alterations that are frequently fatal to children. In the present study, the effects of T. serrulatus venom on the cardiorespiratory system of recently weaned male Wistar rats were evaluated. Fifteen animals were distributed into three groups (n = 5). The control group A received 400 μL ultrapure water by subcutaneous injection, while the experimental groups B and C were injected with scorpion venom (100 and 450 μg, respectively, in 400 μL water). Electrocardiogram (ECG) traces were obtained prior to the experiment, at five-minute intervals up to 30 minutes after treatment. At 40 minutes after envenomation, the animals had...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Rats; Electrocardiography; CK; CK-MB; Troponin; Pulmonary hemorrhages.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200008
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Central lead administration inhibits water intake and sodium appetite in rats BJMBR
De-Castro-e-Silva,E.J.; Castro,L.; Luz,C.P.; Ferreira,H.; Lima,A.K.S.; Souza,F.S.F.; Maldonado,I.; Macêdo,D.F.; Ferreira,M.G.; Bandeira,I.P.V.; Amor,A.L.M.; Carvalho,F.L.Q.; Rocha Jr.,M.A.; Fregoneze,J.B..
We have demonstrated that acute third ventricle injections of lead acetate (PbAc) exert a powerful antidipsogenic effect and induce a significant increase in renal sodium excretion. In the present study we confirm the antidipsogenic effect of lead and demonstrate that central administration of this metal, in minute amounts, significantly reduces salt intake both during dehydration and after central angiotensinergic stimulation. Adult male Wistar rats had the third ventricle cannulated seven days before the experiments. During this period they had free access to distilled water and hypertonic saline solution (1.5%). After a 24-h period of fluid deprivation, experimental animals received third ventricle injections of PbAc (0.3, N = 8 and 3.0 nmol/rat, N =...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead; Angiotensin II; Water intake; Sodium intake; Rats.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000011
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Chronic converting enzyme inhibition normalizes QT interval in aging rats BJMBR
Silva,V.J. Dias da; Ferreira Neto,E.; Salgado,H.C.; Fazan Júnior,R..
The aim of the present study was to investigate the effects of converting enzyme inhibition by captopril on ECG parameters in aged rats. Four-month-old male rats received captopril dissolved in tap water (0.5 mg/l) or tap water for 2 or 20 months. At the end of treatment, under anesthesia, RR and PR interval, P wave and QRS duration, QT and corrected QT interval were measured in all animals. On the following day, chronic ECG (lead II) recordings were performed to quantify supraventricular (SVPB) or ventricular premature beats (VPB). After sacrifice, the hearts were removed and weighed. RR interval was similar in young and untreated aged rats, but significantly larger in aged rats treated with captopril. P wave and QRS length did not differ among groups. PR...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Electrocardiogram; Captopril; Rats.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900003
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